Accessing Single Nucleotide Polymorphisms in Genomic DNA by Direct Multiplex Polymerase Chain Reaction Amplification on Oligonucleotide Microarrays

This study introduces a DNA microarray-based genotyping system for accessing single nucleotide polymorphisms (SNPs) directly from a genomic DNA sample. The described one-step approach combines multiplex amplification and allele-specific solid-phase PCR into an on-chip reaction platform. The multiple...

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Veröffentlicht in:	Analytical biochemistry 2002-04, Vol.303 (1), p.25-33
Hauptverfasser:	Huber, Martin, Mündlein, Axel, Dornstauder, Eva, Schneeberger, Christian, Tempfer, Clemens B., Mueller, Manfred W., Schmidt, Wolfgang M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms DNA - analysis DNA microarray Genome Genotype Humans Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis - methods Polymerase Chain Reaction Polymorphism, Single Nucleotide - genetics sequencing on-a-chip SNP detection solid-phase PCR
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