Recurrent Inguinal Hernia: Disease of the Collagen Matrix?
The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar; recurrent inguinal hernia group = skin of recurrent inguin...
Gespeichert in:
| Veröffentlicht in: | World journal of surgery 2002-04, Vol.26 (4), p.401-408 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 408 |
|---|---|
| container_issue | 4 |
| container_start_page | 401 |
| container_title | World journal of surgery |
| container_volume | 26 |
| creator | Zheng, Hong Si, Zhongyi Kasperk, Reiner Bhardwaj, Rhanjit S. Schumpelick, Volker Klinge, Uwe Klosterhalfen, Bernd |
| description | The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar;
recurrent inguinal hernia group = skin of recurrent inguinal hernias; each n = 5). Reverse transcription‐polymerase chain reaction (RT‐PCR) and Northern blot analysis were used to investigate the expression of procollagen type I/‐ III, MMP‐1, and MMP‐13 mRNAs. Both ratios of procollagen types I to III mRNAs and collagen types I to III were apparently decreased in the recurrent hernia group compared to those of both control groups
(p |
| doi_str_mv | 10.1007/s00268-001-0239-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71543059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71543059</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5255-2daa77ff1bc12e48a08d7d46d8352e7224191e4da190c30b3db2d17bf7fc989f3</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhq0KBFvKD-CCIqT2FpjxR5xwaastsKCtKpVWPVqOM4agbELtjYB_j5ddCYkLJ1uvnhm_fhg7QDhGAH0SAXhR5gCYAxdVrj6wCUrBcy642GITEIVMdxS77GOMd4nTBRQ7bBexQpAaJuz0N7kxBOqX2WV_M7a97bIZhb61p9mPNpKNlA0-W95SNh26zt5Qn_20y9A-fv3Etr3tIu1vzj329_zsz3SWz39dXE6_z3OnuFI5b6zV2nusHXKSpYWy0Y0smlIoTppzmcqQbCxW4ATUoql5g7r22ruqrLzYY1_We-_D8H-kuDSLNjpKZXoaxmg0KilAVQk8egPeDWNIP4qGY1VJlFIkCNeQC0OMgby5D-3ChieDYFZWzdqqSbbMyqpRaeZws3isF9S8Tmw0JuDzBrDR2c4H27s2vnKi4KqQq4bf1txD29HT-y-bf1fX1y9hylaREs8WfI8m</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219941443</pqid></control><display><type>article</type><title>Recurrent Inguinal Hernia: Disease of the Collagen Matrix?</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Access via Wiley Online Library</source><creator>Zheng, Hong ; Si, Zhongyi ; Kasperk, Reiner ; Bhardwaj, Rhanjit S. ; Schumpelick, Volker ; Klinge, Uwe ; Klosterhalfen, Bernd</creator><creatorcontrib>Zheng, Hong ; Si, Zhongyi ; Kasperk, Reiner ; Bhardwaj, Rhanjit S. ; Schumpelick, Volker ; Klinge, Uwe ; Klosterhalfen, Bernd</creatorcontrib><description>The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar;
recurrent inguinal hernia group = skin of recurrent inguinal hernias; each n = 5). Reverse transcription‐polymerase chain reaction (RT‐PCR) and Northern blot analysis were used to investigate the expression of procollagen type I/‐ III, MMP‐1, and MMP‐13 mRNAs. Both ratios of procollagen types I to III mRNAs and collagen types I to III were apparently decreased in the recurrent hernia group compared to those of both control groups
(p <0.01). Significant differences were caused by the increase of both procollagen type III mRNA and collagen type III protein synthesis. A concomitant increase of MMP‐1 and MMP‐13 mRNAs and proteins was also observed in the recurrent hernia group and showed significant differences compared to those of both control groups I and II, respectively (p <0.01). In conclusion, the decreased ratio of collagen types I to III seems not only to be the result of a relative increase in the levels of type III procollagen mRNA but also may be the result of an increase of MMP‐1 and MMP‐13. The data of the present study strongly suggest recurrent inguinal hernias to be a disease of the collagen matrix and result in a clearer understanding of the underlying pathophysiology and may support specific therapeutic strategies in hernia surgery (e.g., surgical meshes).</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-001-0239-5</identifier><identifier>PMID: 11910470</identifier><identifier>CODEN: WJSUDI</identifier><language>eng</language><publisher>New York: Springer‐Verlag</publisher><subject>Abdomen ; Aged ; Biological and medical sciences ; Blotting, Northern ; Child ; Collagen - metabolism ; Collagen Type ; Collagen Type I - metabolism ; Collagen Type III - metabolism ; Collagenases - metabolism ; Gene Expression ; Hernia, Inguinal - physiopathology ; Humans ; Immunohistochemistry ; Infant ; Matrix Metalloproteinase 1 - metabolism ; Matrix Metalloproteinase 13 ; Medical sciences ; Middle Aged ; Northern Blot ; Northern Blot Analysis ; Procollagen - metabolism ; Recurrence ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonucleic Acid ; Skin Fibroblast ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system</subject><ispartof>World journal of surgery, 2002-04, Vol.26 (4), p.401-408</ispartof><rights>2002 International Society of Surgery</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5255-2daa77ff1bc12e48a08d7d46d8352e7224191e4da190c30b3db2d17bf7fc989f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs00268-001-0239-5$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs00268-001-0239-5$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13625649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11910470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Hong</creatorcontrib><creatorcontrib>Si, Zhongyi</creatorcontrib><creatorcontrib>Kasperk, Reiner</creatorcontrib><creatorcontrib>Bhardwaj, Rhanjit S.</creatorcontrib><creatorcontrib>Schumpelick, Volker</creatorcontrib><creatorcontrib>Klinge, Uwe</creatorcontrib><creatorcontrib>Klosterhalfen, Bernd</creatorcontrib><title>Recurrent Inguinal Hernia: Disease of the Collagen Matrix?</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><description>The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar;
recurrent inguinal hernia group = skin of recurrent inguinal hernias; each n = 5). Reverse transcription‐polymerase chain reaction (RT‐PCR) and Northern blot analysis were used to investigate the expression of procollagen type I/‐ III, MMP‐1, and MMP‐13 mRNAs. Both ratios of procollagen types I to III mRNAs and collagen types I to III were apparently decreased in the recurrent hernia group compared to those of both control groups
(p <0.01). Significant differences were caused by the increase of both procollagen type III mRNA and collagen type III protein synthesis. A concomitant increase of MMP‐1 and MMP‐13 mRNAs and proteins was also observed in the recurrent hernia group and showed significant differences compared to those of both control groups I and II, respectively (p <0.01). In conclusion, the decreased ratio of collagen types I to III seems not only to be the result of a relative increase in the levels of type III procollagen mRNA but also may be the result of an increase of MMP‐1 and MMP‐13. The data of the present study strongly suggest recurrent inguinal hernias to be a disease of the collagen matrix and result in a clearer understanding of the underlying pathophysiology and may support specific therapeutic strategies in hernia surgery (e.g., surgical meshes).</description><subject>Abdomen</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Child</subject><subject>Collagen - metabolism</subject><subject>Collagen Type</subject><subject>Collagen Type I - metabolism</subject><subject>Collagen Type III - metabolism</subject><subject>Collagenases - metabolism</subject><subject>Gene Expression</subject><subject>Hernia, Inguinal - physiopathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infant</subject><subject>Matrix Metalloproteinase 1 - metabolism</subject><subject>Matrix Metalloproteinase 13</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Northern Blot</subject><subject>Northern Blot Analysis</subject><subject>Procollagen - metabolism</subject><subject>Recurrence</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Ribonucleic Acid</subject><subject>Skin Fibroblast</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkE1P3DAQhq0KBFvKD-CCIqT2FpjxR5xwaastsKCtKpVWPVqOM4agbELtjYB_j5ddCYkLJ1uvnhm_fhg7QDhGAH0SAXhR5gCYAxdVrj6wCUrBcy642GITEIVMdxS77GOMd4nTBRQ7bBexQpAaJuz0N7kxBOqX2WV_M7a97bIZhb61p9mPNpKNlA0-W95SNh26zt5Qn_20y9A-fv3Etr3tIu1vzj329_zsz3SWz39dXE6_z3OnuFI5b6zV2nusHXKSpYWy0Y0smlIoTppzmcqQbCxW4ATUoql5g7r22ruqrLzYY1_We-_D8H-kuDSLNjpKZXoaxmg0KilAVQk8egPeDWNIP4qGY1VJlFIkCNeQC0OMgby5D-3ChieDYFZWzdqqSbbMyqpRaeZws3isF9S8Tmw0JuDzBrDR2c4H27s2vnKi4KqQq4bf1txD29HT-y-bf1fX1y9hylaREs8WfI8m</recordid><startdate>200204</startdate><enddate>200204</enddate><creator>Zheng, Hong</creator><creator>Si, Zhongyi</creator><creator>Kasperk, Reiner</creator><creator>Bhardwaj, Rhanjit S.</creator><creator>Schumpelick, Volker</creator><creator>Klinge, Uwe</creator><creator>Klosterhalfen, Bernd</creator><general>Springer‐Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200204</creationdate><title>Recurrent Inguinal Hernia: Disease of the Collagen Matrix?</title><author>Zheng, Hong ; Si, Zhongyi ; Kasperk, Reiner ; Bhardwaj, Rhanjit S. ; Schumpelick, Volker ; Klinge, Uwe ; Klosterhalfen, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5255-2daa77ff1bc12e48a08d7d46d8352e7224191e4da190c30b3db2d17bf7fc989f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Child</topic><topic>Collagen - metabolism</topic><topic>Collagen Type</topic><topic>Collagen Type I - metabolism</topic><topic>Collagen Type III - metabolism</topic><topic>Collagenases - metabolism</topic><topic>Gene Expression</topic><topic>Hernia, Inguinal - physiopathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infant</topic><topic>Matrix Metalloproteinase 1 - metabolism</topic><topic>Matrix Metalloproteinase 13</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Northern Blot</topic><topic>Northern Blot Analysis</topic><topic>Procollagen - metabolism</topic><topic>Recurrence</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Ribonucleic Acid</topic><topic>Skin Fibroblast</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Hong</creatorcontrib><creatorcontrib>Si, Zhongyi</creatorcontrib><creatorcontrib>Kasperk, Reiner</creatorcontrib><creatorcontrib>Bhardwaj, Rhanjit S.</creatorcontrib><creatorcontrib>Schumpelick, Volker</creatorcontrib><creatorcontrib>Klinge, Uwe</creatorcontrib><creatorcontrib>Klosterhalfen, Bernd</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Hong</au><au>Si, Zhongyi</au><au>Kasperk, Reiner</au><au>Bhardwaj, Rhanjit S.</au><au>Schumpelick, Volker</au><au>Klinge, Uwe</au><au>Klosterhalfen, Bernd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent Inguinal Hernia: Disease of the Collagen Matrix?</atitle><jtitle>World journal of surgery</jtitle><addtitle>World J Surg</addtitle><date>2002-04</date><risdate>2002</risdate><volume>26</volume><issue>4</issue><spage>401</spage><epage>408</epage><pages>401-408</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><coden>WJSUDI</coden><abstract>The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar;
recurrent inguinal hernia group = skin of recurrent inguinal hernias; each n = 5). Reverse transcription‐polymerase chain reaction (RT‐PCR) and Northern blot analysis were used to investigate the expression of procollagen type I/‐ III, MMP‐1, and MMP‐13 mRNAs. Both ratios of procollagen types I to III mRNAs and collagen types I to III were apparently decreased in the recurrent hernia group compared to those of both control groups
(p <0.01). Significant differences were caused by the increase of both procollagen type III mRNA and collagen type III protein synthesis. A concomitant increase of MMP‐1 and MMP‐13 mRNAs and proteins was also observed in the recurrent hernia group and showed significant differences compared to those of both control groups I and II, respectively (p <0.01). In conclusion, the decreased ratio of collagen types I to III seems not only to be the result of a relative increase in the levels of type III procollagen mRNA but also may be the result of an increase of MMP‐1 and MMP‐13. The data of the present study strongly suggest recurrent inguinal hernias to be a disease of the collagen matrix and result in a clearer understanding of the underlying pathophysiology and may support specific therapeutic strategies in hernia surgery (e.g., surgical meshes).</abstract><cop>New York</cop><pub>Springer‐Verlag</pub><pmid>11910470</pmid><doi>10.1007/s00268-001-0239-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-2313 |
| ispartof | World journal of surgery, 2002-04, Vol.26 (4), p.401-408 |
| issn | 0364-2313 1432-2323 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71543059 |
| source | MEDLINE; SpringerLink Journals; Access via Wiley Online Library |
| subjects | Abdomen Aged Biological and medical sciences Blotting, Northern Child Collagen - metabolism Collagen Type Collagen Type I - metabolism Collagen Type III - metabolism Collagenases - metabolism Gene Expression Hernia, Inguinal - physiopathology Humans Immunohistochemistry Infant Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 13 Medical sciences Middle Aged Northern Blot Northern Blot Analysis Procollagen - metabolism Recurrence Reverse Transcriptase Polymerase Chain Reaction Ribonucleic Acid Skin Fibroblast Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | Recurrent Inguinal Hernia: Disease of the Collagen Matrix? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T08%3A55%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recurrent%20Inguinal%20Hernia:%20Disease%20of%20the%20Collagen%20Matrix?&rft.jtitle=World%20journal%20of%20surgery&rft.au=Zheng,%20Hong&rft.date=2002-04&rft.volume=26&rft.issue=4&rft.spage=401&rft.epage=408&rft.pages=401-408&rft.issn=0364-2313&rft.eissn=1432-2323&rft.coden=WJSUDI&rft_id=info:doi/10.1007/s00268-001-0239-5&rft_dat=%3Cproquest_cross%3E71543059%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219941443&rft_id=info:pmid/11910470&rfr_iscdi=true |