Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase

Objective To extend the life span of human osteoarthritic (OA) articular chondrocytes by introduction of the catalytic component of human telomerase while preserving the chondrocyte‐specific phenotype. Methods Human articular chondrocytes were isolated from the femoral head and tibial plateau of pat...

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Veröffentlicht in:	Arthritis and rheumatism 2002-03, Vol.46 (3), p.683-693
Hauptverfasser:	Piera‐Velazquez, Sonsoles, Jimenez, Sergio A., Stokes, DavidG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Cell Division Cell Survival - drug effects Cells, Cultured Chondrocytes - drug effects Chondrocytes - pathology Chondrocytes - physiology Diseases of the osteoarticular system Gene Transfer Techniques Genetic Vectors Humans Medical sciences Osteoarthritis Osteoarthritis - physiopathology Retroviridae - genetics Telomerase - metabolism Telomerase - pharmacology Telomere - genetics Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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