Association of Epstein-Barr Virus and Nasopharyngeal Carcinoma in Caucasian Patients
We evaluated the association of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) in Spanish patients, and studied the expression of EBV products (latent membrane protein–1 [LMP-1] and ZEBRA proteins) by NPC cells and its possible prognostic value. In situ hybridization (ISH) for EBV-encod...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2002-03, Vol.111 (3), p.210-216 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Plaza, Guillermo Manzanal, Ana I. Fogué, Luis Santón, Almudena Martínez-Montero, Juan Carlos Bellas, Carmen |
| description | We evaluated the association of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) in Spanish patients, and studied the expression of EBV products (latent membrane protein–1 [LMP-1] and ZEBRA proteins) by NPC cells and its possible prognostic value. In situ hybridization (ISH) for EBV-encoded nonpolyadenylated RNAs (EBERs) and immunohistochemical expression of LMP-1 and ZEBRA proteins by immunohistochemistry were examined in formalin-fixed, paraffin-embedded NPC specimens from 30 patients, and a survival analysis was done by the Kaplan-Meier method. We detected EBERs by ISH in 96.67% of the NPC cases, and detected expression of LMP-1 in 43.33% of the NPC cases and expression of ZEBRA protein in 6.67% of the NPC cases. We conclude that ISH for expression of EBERs is an adequate method for detection of EBV in NPC. LMP-1 is not frequently expressed in NPC cells (43.33%). Most NPC cells carry a latent EBV infection. LMP-1 expression might have worsened the prognosis of NPC in our series. |
| doi_str_mv | 10.1177/000348940211100304 |
| format | Article |
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In situ hybridization (ISH) for EBV-encoded nonpolyadenylated RNAs (EBERs) and immunohistochemical expression of LMP-1 and ZEBRA proteins by immunohistochemistry were examined in formalin-fixed, paraffin-embedded NPC specimens from 30 patients, and a survival analysis was done by the Kaplan-Meier method. We detected EBERs by ISH in 96.67% of the NPC cases, and detected expression of LMP-1 in 43.33% of the NPC cases and expression of ZEBRA protein in 6.67% of the NPC cases. We conclude that ISH for expression of EBERs is an adequate method for detection of EBV in NPC. LMP-1 is not frequently expressed in NPC cells (43.33%). Most NPC cells carry a latent EBV infection. LMP-1 expression might have worsened the prognosis of NPC in our series.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940211100304</identifier><identifier>PMID: 11913680</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Biological and medical sciences ; DNA-Binding Proteins - analysis ; DNA-Binding Proteins - genetics ; Epstein-Barr virus ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - diagnosis ; European Continental Ancestry Group - genetics ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic - genetics ; Herpesvirus 4, Human - genetics ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Male ; Medical sciences ; Middle Aged ; Nasopharyngeal Neoplasms - epidemiology ; Nasopharyngeal Neoplasms - genetics ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - virology ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Ribosomal Proteins ; RNA, Viral - analysis ; RNA, Viral - genetics ; RNA-Binding Proteins - analysis ; RNA-Binding Proteins - genetics ; Spain - epidemiology ; Survival Analysis ; Trans-Activators - analysis ; Trans-Activators - genetics ; Viral Matrix Proteins - analysis ; Viral Matrix Proteins - genetics ; Viral Proteins</subject><ispartof>Annals of otology, rhinology & laryngology, 2002-03, Vol.111 (3), p.210-216</ispartof><rights>2002 SAGE Publications</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Annals Publishing Company Mar 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-ba59e772be2b34bceca6c82c4671cd3e0048fe4aeb57671b5b6cabbf02d99fa43</citedby><cites>FETCH-LOGICAL-c396t-ba59e772be2b34bceca6c82c4671cd3e0048fe4aeb57671b5b6cabbf02d99fa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000348940211100304$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000348940211100304$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21821,27926,27927,43623,43624</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13563843$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11913680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plaza, Guillermo</creatorcontrib><creatorcontrib>Manzanal, Ana I.</creatorcontrib><creatorcontrib>Fogué, Luis</creatorcontrib><creatorcontrib>Santón, Almudena</creatorcontrib><creatorcontrib>Martínez-Montero, Juan Carlos</creatorcontrib><creatorcontrib>Bellas, Carmen</creatorcontrib><title>Association of Epstein-Barr Virus and Nasopharyngeal Carcinoma in Caucasian Patients</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>We evaluated the association of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) in Spanish patients, and studied the expression of EBV products (latent membrane protein–1 [LMP-1] and ZEBRA proteins) by NPC cells and its possible prognostic value. In situ hybridization (ISH) for EBV-encoded nonpolyadenylated RNAs (EBERs) and immunohistochemical expression of LMP-1 and ZEBRA proteins by immunohistochemistry were examined in formalin-fixed, paraffin-embedded NPC specimens from 30 patients, and a survival analysis was done by the Kaplan-Meier method. We detected EBERs by ISH in 96.67% of the NPC cases, and detected expression of LMP-1 in 43.33% of the NPC cases and expression of ZEBRA protein in 6.67% of the NPC cases. We conclude that ISH for expression of EBERs is an adequate method for detection of EBV in NPC. LMP-1 is not frequently expressed in NPC cells (43.33%). Most NPC cells carry a latent EBV infection. LMP-1 expression might have worsened the prognosis of NPC in our series.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>DNA-Binding Proteins - analysis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - diagnosis</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Neoplasms - epidemiology</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - virology</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Ribosomal Proteins</subject><subject>RNA, Viral - analysis</subject><subject>RNA, Viral - genetics</subject><subject>RNA-Binding Proteins - analysis</subject><subject>RNA-Binding Proteins - genetics</subject><subject>Spain - epidemiology</subject><subject>Survival Analysis</subject><subject>Trans-Activators - analysis</subject><subject>Trans-Activators - genetics</subject><subject>Viral Matrix Proteins - analysis</subject><subject>Viral Matrix Proteins - genetics</subject><subject>Viral Proteins</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAQhoMoun78AQ9SBL3VzVeb9qiLXyDqYRVvZZJNNdJN1kx78N-bZRcWFDzNTHjmnTcvIceMXjCm1JhSKmRVS8oZY6mncouMWC1FXij-tk1GSyBfEntkH_EzjbKgfJfsMVYzUVZ0RKaXiME46F3wWWiz6wX21vn8CmLMXl0cMAM_yx4Bw-ID4rd_t9BlE4jG-TCHzPk0DAbQgc-ek4z1PR6SnRY6tEfrekBebq6nk7v84en2fnL5kBtRl32uoaitUlxbroXUxhooTcWNLBUzM2GT3aq1EqwuVHrShS4NaN1SPqvrFqQ4IOcr3UUMX4PFvpk7NLbrwNswYKNYIbkqVAJPf4GfYYg-eWs4UykLrniC-AoyMSBG2zaL6Obpzw2jzTLw5m_gaelkrTzouZ1tVtYJJ-BsDQAa6NoI3jjccKIoRSVF4sYrDuHdbuz9c_oH-9aVQw</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Plaza, Guillermo</creator><creator>Manzanal, Ana I.</creator><creator>Fogué, Luis</creator><creator>Santón, Almudena</creator><creator>Martínez-Montero, Juan Carlos</creator><creator>Bellas, Carmen</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20020301</creationdate><title>Association of Epstein-Barr Virus and Nasopharyngeal Carcinoma in Caucasian Patients</title><author>Plaza, Guillermo ; Manzanal, Ana I. ; Fogué, Luis ; Santón, Almudena ; Martínez-Montero, Juan Carlos ; Bellas, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-ba59e772be2b34bceca6c82c4671cd3e0048fe4aeb57671b5b6cabbf02d99fa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>DNA-Binding Proteins - analysis</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - complications</topic><topic>Epstein-Barr Virus Infections - diagnosis</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Neoplasms - epidemiology</topic><topic>Nasopharyngeal Neoplasms - genetics</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - virology</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Ribosomal Proteins</topic><topic>RNA, Viral - analysis</topic><topic>RNA, Viral - genetics</topic><topic>RNA-Binding Proteins - analysis</topic><topic>RNA-Binding Proteins - genetics</topic><topic>Spain - epidemiology</topic><topic>Survival Analysis</topic><topic>Trans-Activators - analysis</topic><topic>Trans-Activators - genetics</topic><topic>Viral Matrix Proteins - analysis</topic><topic>Viral Matrix Proteins - genetics</topic><topic>Viral Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plaza, Guillermo</creatorcontrib><creatorcontrib>Manzanal, Ana I.</creatorcontrib><creatorcontrib>Fogué, Luis</creatorcontrib><creatorcontrib>Santón, Almudena</creatorcontrib><creatorcontrib>Martínez-Montero, Juan Carlos</creatorcontrib><creatorcontrib>Bellas, Carmen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plaza, Guillermo</au><au>Manzanal, Ana I.</au><au>Fogué, Luis</au><au>Santón, Almudena</au><au>Martínez-Montero, Juan Carlos</au><au>Bellas, Carmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Epstein-Barr Virus and Nasopharyngeal Carcinoma in Caucasian Patients</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>111</volume><issue>3</issue><spage>210</spage><epage>216</epage><pages>210-216</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>We evaluated the association of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) in Spanish patients, and studied the expression of EBV products (latent membrane protein–1 [LMP-1] and ZEBRA proteins) by NPC cells and its possible prognostic value. In situ hybridization (ISH) for EBV-encoded nonpolyadenylated RNAs (EBERs) and immunohistochemical expression of LMP-1 and ZEBRA proteins by immunohistochemistry were examined in formalin-fixed, paraffin-embedded NPC specimens from 30 patients, and a survival analysis was done by the Kaplan-Meier method. We detected EBERs by ISH in 96.67% of the NPC cases, and detected expression of LMP-1 in 43.33% of the NPC cases and expression of ZEBRA protein in 6.67% of the NPC cases. We conclude that ISH for expression of EBERs is an adequate method for detection of EBV in NPC. LMP-1 is not frequently expressed in NPC cells (43.33%). Most NPC cells carry a latent EBV infection. LMP-1 expression might have worsened the prognosis of NPC in our series.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>11913680</pmid><doi>10.1177/000348940211100304</doi><tpages>7</tpages></addata></record> |
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| ispartof | Annals of otology, rhinology & laryngology, 2002-03, Vol.111 (3), p.210-216 |
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| subjects | Adolescent Adult Age of Onset Aged Aged, 80 and over Biological and medical sciences DNA-Binding Proteins - analysis DNA-Binding Proteins - genetics Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - diagnosis European Continental Ancestry Group - genetics Female Follow-Up Studies Gene Expression Regulation, Neoplastic - genetics Herpesvirus 4, Human - genetics Humans Immunohistochemistry In Situ Hybridization Male Medical sciences Middle Aged Nasopharyngeal Neoplasms - epidemiology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - virology Neoplasm Staging Prognosis Proportional Hazards Models Ribosomal Proteins RNA, Viral - analysis RNA, Viral - genetics RNA-Binding Proteins - analysis RNA-Binding Proteins - genetics Spain - epidemiology Survival Analysis Trans-Activators - analysis Trans-Activators - genetics Viral Matrix Proteins - analysis Viral Matrix Proteins - genetics Viral Proteins |
| title | Association of Epstein-Barr Virus and Nasopharyngeal Carcinoma in Caucasian Patients |
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