Quantification of Sirolimus by Liquid Chromatography-Tandem Mass Spectrometry Using On-Line Solid-Phase Extraction

Quantification of the new immunosuppressant sirolimus (syn. rapamycin; Rapamune®) in whole blood by chromatography is essential for its clinical use since no immunoassay is available although monitoring is mandatory. Here we report on a rapid and convenient liquid chromatography (LC)-tandem mass spe...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2002-01, Vol.40 (1), p.40-45
Hauptverfasser:	Vogeser, Michael, Fleischer, Claudia, Meiser, Bruno, Groetzner, Jan, Spöhrer, Ute, Seidel, Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, Liquid - methods Humans Immunosuppressive Agents - blood Investigative techniques, diagnostic techniques (general aspects) Mass Spectrometry - methods Medical sciences Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reproducibility of Results Sensitivity and Specificity Sirolimus - blood
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