Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features
Histiocyte‐rich, T‐cell‐rich B‐cell lymphoma: a distinct diffuse large B‐cell lymphoma subtype showing characteristic morphologic and immunophenotypic features Aims: The clinicopathological features of histiocyte‐rich, T‐cell‐rich B‐cell lymphoma (HRTR‐BCL) were first recognized in 1992. In this stu...
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| Veröffentlicht in: | Histopathology 2002-01, Vol.40 (1), p.31-45 |
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| creator | Achten, R Verhoef, G Vanuytsel, L De Wolf-Peeters, C |
| description | Histiocyte‐rich, T‐cell‐rich B‐cell lymphoma: a distinct diffuse large B‐cell lymphoma subtype showing characteristic morphologic and immunophenotypic features
Aims: The clinicopathological features of histiocyte‐rich, T‐cell‐rich B‐cell lymphoma (HRTR‐BCL) were first recognized in 1992. In this study, 60 cases of HRTR‐BCL were analysed in order to provide a detailed morphological and immunophenotypical profile of the disorder.
Methods and results: HRTR‐BCL is easily distinguished from other B‐cell lymphomas rich in stromal T‐cells by (i) a diffuse or vaguely nodular growth pattern, (ii) the presence of a minority population of CD15−, CD20+ large neoplastic B‐cells, (iii) a prominent stromal component composed of both T‐cells and non‐epithelioid histiocytes, and (iv) the scarcity of small reactive B‐cells. These criteria also enable a reliable distinction from lymphocyte‐rich classical Hodgkin’s lymphoma (CHL), from lymphocyte‐predominant Hodgkin’s lymphoma (LPHL), paragranuloma type and from peripheral T‐cell lymphoma. Based on the morphology of the neoplastic cells and on their frequent bcl‐6 immunoreactivity, we speculate that HRTR‐BCL may be derived from a progenitor cell of germinal centre origin.
Conclusions: HRTR‐BCL presents characteristic clinical features, affecting predominantly middle‐aged men who present with advanced stage disease and are at high risk of treatment failure. Considering these distinctive clinicopathological features, recognizing HRTR‐BCL as a lymphoma entity may be justified. |
| doi_str_mv | 10.1046/j.1365-2559.2002.01291.x |
| format | Article |
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Aims: The clinicopathological features of histiocyte‐rich, T‐cell‐rich B‐cell lymphoma (HRTR‐BCL) were first recognized in 1992. In this study, 60 cases of HRTR‐BCL were analysed in order to provide a detailed morphological and immunophenotypical profile of the disorder.
Methods and results: HRTR‐BCL is easily distinguished from other B‐cell lymphomas rich in stromal T‐cells by (i) a diffuse or vaguely nodular growth pattern, (ii) the presence of a minority population of CD15−, CD20+ large neoplastic B‐cells, (iii) a prominent stromal component composed of both T‐cells and non‐epithelioid histiocytes, and (iv) the scarcity of small reactive B‐cells. These criteria also enable a reliable distinction from lymphocyte‐rich classical Hodgkin’s lymphoma (CHL), from lymphocyte‐predominant Hodgkin’s lymphoma (LPHL), paragranuloma type and from peripheral T‐cell lymphoma. Based on the morphology of the neoplastic cells and on their frequent bcl‐6 immunoreactivity, we speculate that HRTR‐BCL may be derived from a progenitor cell of germinal centre origin.
Conclusions: HRTR‐BCL presents characteristic clinical features, affecting predominantly middle‐aged men who present with advanced stage disease and are at high risk of treatment failure. Considering these distinctive clinicopathological features, recognizing HRTR‐BCL as a lymphoma entity may be justified.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1046/j.1365-2559.2002.01291.x</identifier><identifier>PMID: 11903596</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens, CD20 - analysis ; B-cell lymphoma ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Cyclin D1 - analysis ; Diagnosis, Differential ; Female ; Hematologic and hematopoietic diseases ; Histiocytes - chemistry ; Histiocytes - pathology ; Humans ; Immunoenzyme Techniques ; immunohistochemistry ; Immunophenotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lewis X Antigen - analysis ; Lymph Nodes - pathology ; lymphoma classification ; Lymphoma, B-Cell - chemistry ; Lymphoma, B-Cell - classification ; Lymphoma, B-Cell - pathology ; Lymphoma, Large B-Cell, Diffuse - chemistry ; Lymphoma, Large B-Cell, Diffuse - classification ; Lymphoma, Large B-Cell, Diffuse - pathology ; Male ; Medical sciences ; Middle Aged ; morphology ; Spleen - pathology ; T-Lymphocytes - chemistry ; T-Lymphocytes - pathology</subject><ispartof>Histopathology, 2002-01, Vol.40 (1), p.31-45</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4331-f879b4538b9565ea9545b1b1065096d26734b58e2b5e0244bc01fb031df3508f3</citedby><cites>FETCH-LOGICAL-c4331-f879b4538b9565ea9545b1b1065096d26734b58e2b5e0244bc01fb031df3508f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2559.2002.01291.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2559.2002.01291.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13495573$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11903596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Achten, R</creatorcontrib><creatorcontrib>Verhoef, G</creatorcontrib><creatorcontrib>Vanuytsel, L</creatorcontrib><creatorcontrib>De Wolf-Peeters, C</creatorcontrib><title>Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Histiocyte‐rich, T‐cell‐rich B‐cell lymphoma: a distinct diffuse large B‐cell lymphoma subtype showing characteristic morphologic and immunophenotypic features
Aims: The clinicopathological features of histiocyte‐rich, T‐cell‐rich B‐cell lymphoma (HRTR‐BCL) were first recognized in 1992. In this study, 60 cases of HRTR‐BCL were analysed in order to provide a detailed morphological and immunophenotypical profile of the disorder.
Methods and results: HRTR‐BCL is easily distinguished from other B‐cell lymphomas rich in stromal T‐cells by (i) a diffuse or vaguely nodular growth pattern, (ii) the presence of a minority population of CD15−, CD20+ large neoplastic B‐cells, (iii) a prominent stromal component composed of both T‐cells and non‐epithelioid histiocytes, and (iv) the scarcity of small reactive B‐cells. These criteria also enable a reliable distinction from lymphocyte‐rich classical Hodgkin’s lymphoma (CHL), from lymphocyte‐predominant Hodgkin’s lymphoma (LPHL), paragranuloma type and from peripheral T‐cell lymphoma. Based on the morphology of the neoplastic cells and on their frequent bcl‐6 immunoreactivity, we speculate that HRTR‐BCL may be derived from a progenitor cell of germinal centre origin.
Conclusions: HRTR‐BCL presents characteristic clinical features, affecting predominantly middle‐aged men who present with advanced stage disease and are at high risk of treatment failure. Considering these distinctive clinicopathological features, recognizing HRTR‐BCL as a lymphoma entity may be justified.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD20 - analysis</subject><subject>B-cell lymphoma</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cyclin D1 - analysis</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histiocytes - chemistry</subject><subject>Histiocytes - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>immunohistochemistry</subject><subject>Immunophenotyping</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lewis X Antigen - analysis</subject><subject>Lymph Nodes - pathology</subject><subject>lymphoma classification</subject><subject>Lymphoma, B-Cell - chemistry</subject><subject>Lymphoma, B-Cell - classification</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, Large B-Cell, Diffuse - chemistry</subject><subject>Lymphoma, Large B-Cell, Diffuse - classification</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>morphology</subject><subject>Spleen - pathology</subject><subject>T-Lymphocytes - chemistry</subject><subject>T-Lymphocytes - pathology</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuO0zAARS0EYsrALyBvYEWCH3ESI7GYqaAdqTwkBs3Ssh27TUniYCea5mv4VZy2mpFYscqNfa5fBwCIUYpRlr_fp5jmLCGM8ZQgRFKECcfp4QlYPEw8BQtEEU8QzosL8CKEPUK4oIQ8BxcYc0QZzxfgz7oOQ-30NJjE13r3Dt4m2jTN8QdeHzNsprbfuVZ-gBJWM9_pIQZrx2BgI_3W_EvCMKph6g0MO3dfd1uod9JLPRg_1zVsnY9c47Yxy66CdduOnet3pnOxFgetkcPoTXgJnlnZBPPq_L0EPz9_ul2uk8231c3yapPojFKc2LLgKmO0VJzlzEjOMqawwihniOcVyQuaKVYaophBJMuURtgqRHFlKUOlpZfg7Wnd3rvfowmDaOswX0l2xo1BFJjRguckguUJ1N6F4I0Vva9b6SeBkZjliL2YHYjZgZjliKMccYjV1-c9RtWa6rF4thGBN2dABi0b62Wn6_DI0YwzVtDIfTxx93Vjpv8-gFjf_JhT7CenfpRhDg996X-J-FAFE3dfV2JFvqyX19834o7-BcHyvFk</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Achten, R</creator><creator>Verhoef, G</creator><creator>Vanuytsel, L</creator><creator>De Wolf-Peeters, C</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features</title><author>Achten, R ; Verhoef, G ; Vanuytsel, L ; De Wolf-Peeters, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4331-f879b4538b9565ea9545b1b1065096d26734b58e2b5e0244bc01fb031df3508f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, CD20 - analysis</topic><topic>B-cell lymphoma</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cyclin D1 - analysis</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Histiocytes - chemistry</topic><topic>Histiocytes - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>immunohistochemistry</topic><topic>Immunophenotyping</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lewis X Antigen - analysis</topic><topic>Lymph Nodes - pathology</topic><topic>lymphoma classification</topic><topic>Lymphoma, B-Cell - chemistry</topic><topic>Lymphoma, B-Cell - classification</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Lymphoma, Large B-Cell, Diffuse - chemistry</topic><topic>Lymphoma, Large B-Cell, Diffuse - classification</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>morphology</topic><topic>Spleen - pathology</topic><topic>T-Lymphocytes - chemistry</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Achten, R</creatorcontrib><creatorcontrib>Verhoef, G</creatorcontrib><creatorcontrib>Vanuytsel, L</creatorcontrib><creatorcontrib>De Wolf-Peeters, C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Achten, R</au><au>Verhoef, G</au><au>Vanuytsel, L</au><au>De Wolf-Peeters, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2002-01</date><risdate>2002</risdate><volume>40</volume><issue>1</issue><spage>31</spage><epage>45</epage><pages>31-45</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Histiocyte‐rich, T‐cell‐rich B‐cell lymphoma: a distinct diffuse large B‐cell lymphoma subtype showing characteristic morphologic and immunophenotypic features
Aims: The clinicopathological features of histiocyte‐rich, T‐cell‐rich B‐cell lymphoma (HRTR‐BCL) were first recognized in 1992. In this study, 60 cases of HRTR‐BCL were analysed in order to provide a detailed morphological and immunophenotypical profile of the disorder.
Methods and results: HRTR‐BCL is easily distinguished from other B‐cell lymphomas rich in stromal T‐cells by (i) a diffuse or vaguely nodular growth pattern, (ii) the presence of a minority population of CD15−, CD20+ large neoplastic B‐cells, (iii) a prominent stromal component composed of both T‐cells and non‐epithelioid histiocytes, and (iv) the scarcity of small reactive B‐cells. These criteria also enable a reliable distinction from lymphocyte‐rich classical Hodgkin’s lymphoma (CHL), from lymphocyte‐predominant Hodgkin’s lymphoma (LPHL), paragranuloma type and from peripheral T‐cell lymphoma. Based on the morphology of the neoplastic cells and on their frequent bcl‐6 immunoreactivity, we speculate that HRTR‐BCL may be derived from a progenitor cell of germinal centre origin.
Conclusions: HRTR‐BCL presents characteristic clinical features, affecting predominantly middle‐aged men who present with advanced stage disease and are at high risk of treatment failure. Considering these distinctive clinicopathological features, recognizing HRTR‐BCL as a lymphoma entity may be justified.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>11903596</pmid><doi>10.1046/j.1365-2559.2002.01291.x</doi><tpages>15</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antigens, CD20 - analysis B-cell lymphoma Biological and medical sciences Biomarkers, Tumor - analysis Cyclin D1 - analysis Diagnosis, Differential Female Hematologic and hematopoietic diseases Histiocytes - chemistry Histiocytes - pathology Humans Immunoenzyme Techniques immunohistochemistry Immunophenotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lewis X Antigen - analysis Lymph Nodes - pathology lymphoma classification Lymphoma, B-Cell - chemistry Lymphoma, B-Cell - classification Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - chemistry Lymphoma, Large B-Cell, Diffuse - classification Lymphoma, Large B-Cell, Diffuse - pathology Male Medical sciences Middle Aged morphology Spleen - pathology T-Lymphocytes - chemistry T-Lymphocytes - pathology |
| title | Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features |
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