Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity

Antimicrobial peptides are important host-defense molecules of innate immunity. Cathelicidins are a diverse family of potent, rapidly acting and broadly effective antimicrobial peptides, which are produced by a variety of cells. This review examines the classification, antimicrobial spectrum, mechan...

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Veröffentlicht in:	Microbes and Infection 2002-03, Vol.4 (3), p.361-372
Hauptverfasser:	Ramanathan, Balaji, Davis, Elizabeth G., Ross, Christopher R., Blecha, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Infective Agents - metabolism Anti-Infective Agents - pharmacology Antimicrobial Cationic Peptides - classification Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Bacteriology Biological and medical sciences Blood Proteins - biosynthesis Blood Proteins - genetics Blood Proteins - metabolism Cathelicidin Fundamental and applied biological sciences. Psychology Immunity, Innate Innate immunity Microbiology Models, Genetic Natural antibiotics Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Protein Precursors - biosynthesis Protein Precursors - genetics Protein Precursors - metabolism
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Zusammenfassung:	Antimicrobial peptides are important host-defense molecules of innate immunity. Cathelicidins are a diverse family of potent, rapidly acting and broadly effective antimicrobial peptides, which are produced by a variety of cells. This review examines the classification, antimicrobial spectrum, mechanism of action, and regulation of cathelicidins.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/S1286-4579(02)01549-6