Circulating tumor-reactive CD8+ T cells in melanoma patients contain a CD45RA+CCR7- effector subset exerting ex vivo tumor-specific cytolytic activity

To defend the host from malignancies, the immune system can spontaneously raise CD8(+) T-cell responses against tumor antigens. Investigating the functional state of tumor-reactive cytolytic T cells in cancer patients is a key step for understanding the role of these cells in tumor immunosurveillanc...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-03, Vol.62 (6), p.1743-1750
Hauptverfasser:	VALMORI, Danila, SCHEIBENBOGEN, Carmen, LIPP, Martin, DIETRICH, Pierre-Yves, THIEL, Eckhard, CEROTTINI, Jean-Charles, LIENARD, Danielle, KEILHOLZ, Ulrich, DUTOIT, Valerie, NAGORSEN, Dirk, ASEMISSEN, Anne Marie, RUBIO-GODOY, Verena, RIMOLDI, Donata, GUILLAUME, Philippe, ROMERO, Pedro, SCHADENDORF, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cytotoxicity, Immunologic Epitopes, T-Lymphocyte - immunology HLA-A2 Antigen - immunology Host-tumor relations. Immunology. Biological markers Humans Leukocyte Common Antigens - blood Leukocyte Common Antigens - immunology Lymphocyte Activation - immunology Medical sciences Melanoma - blood Melanoma - immunology Monophenol Monooxygenase - immunology Receptors, CCR7 Receptors, Chemokine - blood Receptors, Chemokine - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Tumors
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