Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives
Dihydropyrimidines 4a-r have been synthesized by base catalysed condensation of beta-aroylpropanoic acid, guanidine nitrate and aromatic aldehyde. Structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compar...
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| Veröffentlicht in: | Acta pharmaceutica (Zagreb, Croatia) Croatia), 2003-09, Vol.53 (3), p.223-229 |
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| container_title | Acta pharmaceutica (Zagreb, Croatia) |
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| creator | Bahekar, Sushilkumar S Shinde, Devanand B |
| description | Dihydropyrimidines 4a-r have been synthesized by base catalysed condensation of beta-aroylpropanoic acid, guanidine nitrate and aromatic aldehyde. Structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with standard drug diclofenac sodium. |
| format | Article |
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Structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with standard drug diclofenac sodium.</abstract><cop>Croatia</cop><pmid>14769245</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Acta pharmaceutica (Zagreb, Croatia), 2003-09, Vol.53 (3), p.223-229 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Edema - drug therapy Female Male Pyrimidines - chemical synthesis Pyrimidines - therapeutic use Rats |
| title | Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives |
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