Preoperative Portal Embolization in Patients with Hepatocellular Carcinoma
The factors that contribute to the effect of portal vein embolization before hepatectomy for hepatocellular carcinoma are unclear. Sixty-six patients with hepatocellular carcinoma were enrolled in the study. Changes in liver function, portal vein pressure, and liver volume after embolization were ex...
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| Veröffentlicht in: | World journal of surgery 2002-01, Vol.26 (1), p.105-110 |
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| creator | Sugawara, Yasuhiko Yamamoto, Junji Higashi, Hisato Yamasaki, Susumu Shimada, Kazuaki Kosuge, Tomoo Takayama, Tadatoshi Makuuchi, Masatoshi |
| description | The factors that contribute to the effect of portal vein embolization before hepatectomy for hepatocellular carcinoma are unclear. Sixty-six patients with hepatocellular carcinoma were enrolled in the study. Changes in liver function, portal vein pressure, and liver volume after embolization were examined. A multiple linear regression analysis was performed to identify factors that independently contributed to the effects of portal vein embolization. The acceptable volume ratio of the remnant liver was calculated from liver function and compared with the volume ratio of the non-embolized liver. No postoperative deaths were observed after portal vein embolization or hepatectomy. Serum total bilirubin and prothrombin time did not change significantly after portal vein embolization. In patients who underwent arterial embolization before portal vein embolization, aminotransferase levels increased significantly. The only factor that could significantly predict the atrophy effects of portal vein embolization was previous arterial embolization. The volume ratio of the non-embolized liver was smaller than the acceptable volume ratio of the remnant liver in 18 of 40 patients and increased over the acceptable volume ratio in all cases after portal vein embolization. Portal vein embolization induced atrophy or hypertrophy of the embolized or non-embolized liver sufficiently, even when the liver was dysfunctional or cirrhotic. The atrophy effects were significant, especially when arterial embolization had been performed before portal vein embolization. |
| doi_str_mv | 10.1007/s00268-001-0189-y |
| format | Article |
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Sixty-six patients with hepatocellular carcinoma were enrolled in the study. Changes in liver function, portal vein pressure, and liver volume after embolization were examined. A multiple linear regression analysis was performed to identify factors that independently contributed to the effects of portal vein embolization. The acceptable volume ratio of the remnant liver was calculated from liver function and compared with the volume ratio of the non-embolized liver. No postoperative deaths were observed after portal vein embolization or hepatectomy. Serum total bilirubin and prothrombin time did not change significantly after portal vein embolization. In patients who underwent arterial embolization before portal vein embolization, aminotransferase levels increased significantly. The only factor that could significantly predict the atrophy effects of portal vein embolization was previous arterial embolization. The volume ratio of the non-embolized liver was smaller than the acceptable volume ratio of the remnant liver in 18 of 40 patients and increased over the acceptable volume ratio in all cases after portal vein embolization. Portal vein embolization induced atrophy or hypertrophy of the embolized or non-embolized liver sufficiently, even when the liver was dysfunctional or cirrhotic. The atrophy effects were significant, especially when arterial embolization had been performed before portal vein embolization.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-001-0189-y</identifier><identifier>PMID: 11898042</identifier><identifier>CODEN: WJSUDI</identifier><language>eng</language><publisher>New York: Springer‐Verlag</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - physiopathology ; Carcinoma, Hepatocellular - surgery ; Embolization, Therapeutic ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatectomy ; Humans ; Liver - pathology ; Liver - physiopathology ; Liver - surgery ; Liver Neoplasms - pathology ; Liver Neoplasms - physiopathology ; Liver Neoplasms - surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Outcome Assessment (Health Care) ; Portal Vein - pathology ; Portal Vein - physiopathology ; Portal Vein - surgery ; Preoperative Care ; Time Factors ; Tumors</subject><ispartof>World journal of surgery, 2002-01, Vol.26 (1), p.105-110</ispartof><rights>2002 International Society of Surgery</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411Y-133bb0204463e4e365b38f84af267da53fe0757f54be2a23ac36fc1ac4c9d1093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs00268-001-0189-y$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs00268-001-0189-y$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13456990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11898042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugawara, Yasuhiko</creatorcontrib><creatorcontrib>Yamamoto, Junji</creatorcontrib><creatorcontrib>Higashi, Hisato</creatorcontrib><creatorcontrib>Yamasaki, Susumu</creatorcontrib><creatorcontrib>Shimada, Kazuaki</creatorcontrib><creatorcontrib>Kosuge, Tomoo</creatorcontrib><creatorcontrib>Takayama, Tadatoshi</creatorcontrib><creatorcontrib>Makuuchi, Masatoshi</creatorcontrib><title>Preoperative Portal Embolization in Patients with Hepatocellular Carcinoma</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><description>The factors that contribute to the effect of portal vein embolization before hepatectomy for hepatocellular carcinoma are unclear. Sixty-six patients with hepatocellular carcinoma were enrolled in the study. Changes in liver function, portal vein pressure, and liver volume after embolization were examined. A multiple linear regression analysis was performed to identify factors that independently contributed to the effects of portal vein embolization. The acceptable volume ratio of the remnant liver was calculated from liver function and compared with the volume ratio of the non-embolized liver. No postoperative deaths were observed after portal vein embolization or hepatectomy. Serum total bilirubin and prothrombin time did not change significantly after portal vein embolization. In patients who underwent arterial embolization before portal vein embolization, aminotransferase levels increased significantly. The only factor that could significantly predict the atrophy effects of portal vein embolization was previous arterial embolization. The volume ratio of the non-embolized liver was smaller than the acceptable volume ratio of the remnant liver in 18 of 40 patients and increased over the acceptable volume ratio in all cases after portal vein embolization. Portal vein embolization induced atrophy or hypertrophy of the embolized or non-embolized liver sufficiently, even when the liver was dysfunctional or cirrhotic. The atrophy effects were significant, especially when arterial embolization had been performed before portal vein embolization.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - physiopathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Embolization, Therapeutic</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver - physiopathology</subject><subject>Liver - surgery</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - physiopathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Outcome Assessment (Health Care)</subject><subject>Portal Vein - pathology</subject><subject>Portal Vein - physiopathology</subject><subject>Portal Vein - surgery</subject><subject>Preoperative Care</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkF1LHDEUhoNUdLX-AG_KULB3U3NyMpmZO2WxWhFcsKV4Fc5kMzQyM1mTGWX99c12F4Te9OocXp7zwcPYKfCvwHl5HjkXqso5h5xDVefrPTYDiSIXKPADm3FUMvWAh-woxqfElYqrA3YIia64FDN2uwjWr2yg0b3YbOHDSF121Te-c28p80PmhmyROjuMMXt14-_sxq5o9MZ23dRRyOYUjBt8Tx_ZfktdtCe7esx-frv6Mb_J7-6vv88v73IjAR5zQGwaLriUCq20qIoGq7aS1ApVLqnA1vKyKNtCNlaQQDKoWgNkpKmXwGs8Zl-2e1fBP082jrp3cfMODdZPUZdQIJYoE_j5H_DJT2FIv2kBda0AhEgQbCETfIzBtnoVXE9hrYHrjWW9tayTPb2xrNdp5tNu8dT0dvk-sdOagLMdQNFQ1wYajIvvHMpC1TVP3MWWe3WdXf__sv51-_DwN0zZJnrEP7Y_lzY</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Sugawara, Yasuhiko</creator><creator>Yamamoto, Junji</creator><creator>Higashi, Hisato</creator><creator>Yamasaki, Susumu</creator><creator>Shimada, Kazuaki</creator><creator>Kosuge, Tomoo</creator><creator>Takayama, Tadatoshi</creator><creator>Makuuchi, Masatoshi</creator><general>Springer‐Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Preoperative Portal Embolization in Patients with Hepatocellular Carcinoma</title><author>Sugawara, Yasuhiko ; Yamamoto, Junji ; Higashi, Hisato ; Yamasaki, Susumu ; Shimada, Kazuaki ; Kosuge, Tomoo ; Takayama, Tadatoshi ; Makuuchi, Masatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411Y-133bb0204463e4e365b38f84af267da53fe0757f54be2a23ac36fc1ac4c9d1093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - physiopathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Embolization, Therapeutic</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver - physiopathology</topic><topic>Liver - surgery</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - physiopathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Outcome Assessment (Health Care)</topic><topic>Portal Vein - pathology</topic><topic>Portal Vein - physiopathology</topic><topic>Portal Vein - surgery</topic><topic>Preoperative Care</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugawara, Yasuhiko</creatorcontrib><creatorcontrib>Yamamoto, Junji</creatorcontrib><creatorcontrib>Higashi, Hisato</creatorcontrib><creatorcontrib>Yamasaki, Susumu</creatorcontrib><creatorcontrib>Shimada, Kazuaki</creatorcontrib><creatorcontrib>Kosuge, Tomoo</creatorcontrib><creatorcontrib>Takayama, Tadatoshi</creatorcontrib><creatorcontrib>Makuuchi, Masatoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugawara, Yasuhiko</au><au>Yamamoto, Junji</au><au>Higashi, Hisato</au><au>Yamasaki, Susumu</au><au>Shimada, Kazuaki</au><au>Kosuge, Tomoo</au><au>Takayama, Tadatoshi</au><au>Makuuchi, Masatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative Portal Embolization in Patients with Hepatocellular Carcinoma</atitle><jtitle>World journal of surgery</jtitle><addtitle>World J Surg</addtitle><date>2002-01</date><risdate>2002</risdate><volume>26</volume><issue>1</issue><spage>105</spage><epage>110</epage><pages>105-110</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><coden>WJSUDI</coden><abstract>The factors that contribute to the effect of portal vein embolization before hepatectomy for hepatocellular carcinoma are unclear. Sixty-six patients with hepatocellular carcinoma were enrolled in the study. Changes in liver function, portal vein pressure, and liver volume after embolization were examined. A multiple linear regression analysis was performed to identify factors that independently contributed to the effects of portal vein embolization. The acceptable volume ratio of the remnant liver was calculated from liver function and compared with the volume ratio of the non-embolized liver. No postoperative deaths were observed after portal vein embolization or hepatectomy. Serum total bilirubin and prothrombin time did not change significantly after portal vein embolization. In patients who underwent arterial embolization before portal vein embolization, aminotransferase levels increased significantly. The only factor that could significantly predict the atrophy effects of portal vein embolization was previous arterial embolization. The volume ratio of the non-embolized liver was smaller than the acceptable volume ratio of the remnant liver in 18 of 40 patients and increased over the acceptable volume ratio in all cases after portal vein embolization. Portal vein embolization induced atrophy or hypertrophy of the embolized or non-embolized liver sufficiently, even when the liver was dysfunctional or cirrhotic. The atrophy effects were significant, especially when arterial embolization had been performed before portal vein embolization.</abstract><cop>New York</cop><pub>Springer‐Verlag</pub><pmid>11898042</pmid><doi>10.1007/s00268-001-0189-y</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - physiopathology Carcinoma, Hepatocellular - surgery Embolization, Therapeutic Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Hepatectomy Humans Liver - pathology Liver - physiopathology Liver - surgery Liver Neoplasms - pathology Liver Neoplasms - physiopathology Liver Neoplasms - surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Outcome Assessment (Health Care) Portal Vein - pathology Portal Vein - physiopathology Portal Vein - surgery Preoperative Care Time Factors Tumors |
| title | Preoperative Portal Embolization in Patients with Hepatocellular Carcinoma |
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