Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor
Clinical studies have shown that metastatic spread is associated with hypoxia in the primary tumor. The mechanism behind this association has not been identified and, in fact, it has not been established whether hypoxia induces metastasis or whether the most metastatic cell phenotypes develop the mo...
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Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2002-03, Vol.62 (6), p.1847-1853 |
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