The Cdc42 Target ACK2 Interacts with Sorting Nexin 9 (SH3PX1) to Regulate Epidermal Growth Factor Receptor Degradation

Activated Cdc42-associated kinase-2 (ACK2) is a non-receptor tyrosine kinase that serves as a specific effector for Cdc42, a Rho family small G-protein. Recently, we have found that ACK2 directly interacts with clathrin heavy chain through a clathrin-binding motif that is conserved in all endocytic...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (12), p.10134-10138
Hauptverfasser:	Lin, Qiong, Lo, Charles G., Cerione, Richard A., Yang, Wannian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism cdc42 GTP-Binding Protein - metabolism Clathrin - metabolism COS Cells Culture Media, Serum-Free - pharmacology Electrophoresis, Polyacrylamide Gel Endocytosis ErbB Receptors - metabolism Escherichia coli - metabolism Gene Library Glutathione Transferase - metabolism Humans Phosphorylation Protein Binding Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Recombinant Fusion Proteins - metabolism Sorting Nexins src Homology Domains Time Factors Transfection Tyrosine - metabolism Vesicular Transport Proteins
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