Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv

Single chain antibodies (scFv) represent powerful interventional agents for the achievement of targeted therapeutics. The practical utility of these agents have been limited, however, by difficulties related to production of recombinant scFv and the achievement of effective and sustained levels of s...

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Veröffentlicht in:	Gene therapy 2002-02, Vol.9 (4), p.256-262
Hauptverfasser:	ARAFAT, W. O, GOMEZ-NAVARRO, J, SIEGAL, G. P, ALVAREZ, R. D, HEMMINKI, A, NETTELBECK, D. M, CURIEL, D. T, BUCHSBAUM, D. J, XIANG, J, WANG, M, CASADO, E, BARKER, S. D, MAHASRESHTI, P. J, HAISMA, H. J, BARNES, M. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Antibodies, Monoclonal - blood Antibodies, Monoclonal - genetics Biological and medical sciences ErbB protein ErbB-2 protein Expression vectors Female Fundamental and applied biological sciences. Psychology Gene Targeting - methods Gene transfer Genetic Therapy - methods Genetic Vectors Humans Mice Mice, Nude Molecular and cellular biology Neoplasm Transplantation Ovarian Neoplasms - prevention & control Receptor, ErbB-2 - immunology Transfection Tumor Cells, Cultured Tumors
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