Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay
. Halvorsen DS, Børvik T, Njølstad I, Gutteberg TJ, Vorland LH, Hansen J‐B (University Hospital of Tromsø; and Institute of Community Medicine, Tromsø, Norway). Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmu...
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| description | . Halvorsen DS, Børvik T, Njølstad I, Gutteberg TJ, Vorland LH, Hansen J‐B (University Hospital of Tromsø; and Institute of Community Medicine, Tromsø, Norway). Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence (MIF) test and an enzyme immunoassay (EIA). J Intern Med 2002; 251: 142–147.
Objectives. Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA‐ and IgG seroprevalence in young survivors of myocardial infarction and matched controls, and to compare the agreement of detecting antibodies between a MIF test and an enzyme immunoassay (EIA).
Design. A total of 61 patients hospitalized as a result of myocardial infarction, 51 patients hospitalized with chest pain and negative exercise‐ECG and 61 age and sex matched controls (mean age 53.3 years, range 40–60 years) were included in this case–control study. Serological comparisons were expressed as sensitivity, specificity and interrater agreement (K or Kw) of the EIA test related to the MIF test.
Results. Presence of IgA (cut off=16) antibodies was significantly higher in coronary heart patients compared with controls for both assays (P=0.02 by the MIF and P=0.05 by the EIA test). The presence of IgG (cut off=32) antibodies was significantly higher amongst patients (P=0.05) when analysed by the MIF‐test, but not with the EIA‐test (P=0.16). The strength of agreement between the assays was good for both IgA‐ (Kw=0.67) and IgG (Kw=0.79) analyses. However, only 52.8% of the IgA samples classified as strong positive (cut‐off=32) by the MIF test were strong positive by the EIA test (K=0.56). Only 73.2% of the negative IgG samples ( |
| doi_str_mv | 10.1046/j.1365-2796.2002.00942.x |
| format | Article |
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Objectives. Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA‐ and IgG seroprevalence in young survivors of myocardial infarction and matched controls, and to compare the agreement of detecting antibodies between a MIF test and an enzyme immunoassay (EIA).
Design. A total of 61 patients hospitalized as a result of myocardial infarction, 51 patients hospitalized with chest pain and negative exercise‐ECG and 61 age and sex matched controls (mean age 53.3 years, range 40–60 years) were included in this case–control study. Serological comparisons were expressed as sensitivity, specificity and interrater agreement (K or Kw) of the EIA test related to the MIF test.
Results. Presence of IgA (cut off=16) antibodies was significantly higher in coronary heart patients compared with controls for both assays (P=0.02 by the MIF and P=0.05 by the EIA test). The presence of IgG (cut off=32) antibodies was significantly higher amongst patients (P=0.05) when analysed by the MIF‐test, but not with the EIA‐test (P=0.16). The strength of agreement between the assays was good for both IgA‐ (Kw=0.67) and IgG (Kw=0.79) analyses. However, only 52.8% of the IgA samples classified as strong positive (cut‐off=32) by the MIF test were strong positive by the EIA test (K=0.56). Only 73.2% of the negative IgG samples (<32) by the MIF‐test turned out negative by the EIA‐test (K=0.73).
Conclusions. Dependent on assay and cut‐off level, there is an increased C. pneumoniae IgA‐ and IgG seroprevalence in young survivors of myocardial infarction compared with controls. Despite the subjective interpretation of MIF‐titres, the strength of agreement between the EIA and MIF tests was good for both antibody classes. However, misclassification of highly positive IgA samples and negative IgG samples by the MIF test may influence study conclusions. We conclude that the choice of serological method is of major importance when evaluating a possible relationship between C. pneumoniae and coronary heart disease.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1046/j.1365-2796.2002.00942.x</identifier><identifier>PMID: 11905590</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adult ; Bacterial diseases ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Chlamydia Infections - immunology ; Chlamydia Infections - microbiology ; Chlamydia pneumoniae antibodies ; Chlamydophila pneumoniae - immunology ; Coronary heart disease ; EIA test ; Female ; Fluorescent Antibody Technique ; Heart ; Human bacterial diseases ; Humans ; Immunoenzyme Techniques ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; MIF test ; Miscellaneous ; Myocardial Infarction - immunology ; Myocardial Infarction - microbiology ; Risk Factors ; Seroepidemiologic Studies ; seroprevalence</subject><ispartof>Journal of internal medicine, 2002-02, Vol.251 (2), p.142-147</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Feb 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4222-82b30fa3716705c63dd4166347d4537398f4d5362cf555f0805303aec61a6b493</citedby><cites>FETCH-LOGICAL-c4222-82b30fa3716705c63dd4166347d4537398f4d5362cf555f0805303aec61a6b493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2796.2002.00942.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2796.2002.00942.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13824994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11905590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halvorsen, D. S.</creatorcontrib><creatorcontrib>Børvik, T.</creatorcontrib><creatorcontrib>Njølstad, I.</creatorcontrib><creatorcontrib>Gutteberg, T. J.</creatorcontrib><creatorcontrib>Vorland, L. H.</creatorcontrib><creatorcontrib>Hansen, J.‐B.</creatorcontrib><title>Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>. Halvorsen DS, Børvik T, Njølstad I, Gutteberg TJ, Vorland LH, Hansen J‐B (University Hospital of Tromsø; and Institute of Community Medicine, Tromsø, Norway). Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence (MIF) test and an enzyme immunoassay (EIA). J Intern Med 2002; 251: 142–147.
Objectives. Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA‐ and IgG seroprevalence in young survivors of myocardial infarction and matched controls, and to compare the agreement of detecting antibodies between a MIF test and an enzyme immunoassay (EIA).
Design. A total of 61 patients hospitalized as a result of myocardial infarction, 51 patients hospitalized with chest pain and negative exercise‐ECG and 61 age and sex matched controls (mean age 53.3 years, range 40–60 years) were included in this case–control study. Serological comparisons were expressed as sensitivity, specificity and interrater agreement (K or Kw) of the EIA test related to the MIF test.
Results. Presence of IgA (cut off=16) antibodies was significantly higher in coronary heart patients compared with controls for both assays (P=0.02 by the MIF and P=0.05 by the EIA test). The presence of IgG (cut off=32) antibodies was significantly higher amongst patients (P=0.05) when analysed by the MIF‐test, but not with the EIA‐test (P=0.16). The strength of agreement between the assays was good for both IgA‐ (Kw=0.67) and IgG (Kw=0.79) analyses. However, only 52.8% of the IgA samples classified as strong positive (cut‐off=32) by the MIF test were strong positive by the EIA test (K=0.56). Only 73.2% of the negative IgG samples (<32) by the MIF‐test turned out negative by the EIA‐test (K=0.73).
Conclusions. Dependent on assay and cut‐off level, there is an increased C. pneumoniae IgA‐ and IgG seroprevalence in young survivors of myocardial infarction compared with controls. Despite the subjective interpretation of MIF‐titres, the strength of agreement between the EIA and MIF tests was good for both antibody classes. However, misclassification of highly positive IgA samples and negative IgG samples by the MIF test may influence study conclusions. We conclude that the choice of serological method is of major importance when evaluating a possible relationship between C. pneumoniae and coronary heart disease.</description><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Chlamydia Infections - immunology</subject><subject>Chlamydia Infections - microbiology</subject><subject>Chlamydia pneumoniae antibodies</subject><subject>Chlamydophila pneumoniae - immunology</subject><subject>Coronary heart disease</subject><subject>EIA test</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Heart</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MIF test</subject><subject>Miscellaneous</subject><subject>Myocardial Infarction - immunology</subject><subject>Myocardial Infarction - microbiology</subject><subject>Risk Factors</subject><subject>Seroepidemiologic Studies</subject><subject>seroprevalence</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURiMEokPhFZCFBLsE_ydesBiNaBlU1A2sLcdxikexPdiT0rDqI_A8PA5PgjMTUYkVq3sln_vpWF9RAAQrBCl_u6sQ4azEteAVhhBXEAqKq7tHxervw-NiBQWjJW8wPCuepbSDEBHI4dPiDCEBGRNwVfzafB2UmzqrwN6b0QVvlQHbm_Xv-59A-S6vl3kebBs6axKwHkxh9DcgjfHW3oaYQOiBm4JWMYcMGehV1AcbfAXWQAe3V9Gm4GdsyZlAZw7myIB2Ago4q2Owzo0-9MMYoknaeG3AwaTDUUJ5YPyPyRlwolRKanpePOnVkMyLZZ4XXy7ef958KK-uL7eb9VWpKca4bHBLYK9IjXgNmeak6yjinNC6o4zURDQ97RjhWPeMsR42kBFIlNEcKd5SQc6LN6fcfQzfxqwknc2Cw6C8CWOSNWJYEEwz-OofcBfG6LObRKIWhDFaZ6g5QfnLKUXTy320TsVJIijncuVOzh3KuUM5lyuP5cq7fPpyyR9bZ7qHw6XNDLxeAJW0GvqovLbpgSMNpkLMou9O3Hc7mOm_BeTH6-2nvJE_M9bDdw</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Halvorsen, D. S.</creator><creator>Børvik, T.</creator><creator>Njølstad, I.</creator><creator>Gutteberg, T. J.</creator><creator>Vorland, L. H.</creator><creator>Hansen, J.‐B.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200202</creationdate><title>Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay</title><author>Halvorsen, D. S. ; Børvik, T. ; Njølstad, I. ; Gutteberg, T. J. ; Vorland, L. H. ; Hansen, J.‐B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4222-82b30fa3716705c63dd4166347d4537398f4d5362cf555f0805303aec61a6b493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Chlamydia Infections - immunology</topic><topic>Chlamydia Infections - microbiology</topic><topic>Chlamydia pneumoniae antibodies</topic><topic>Chlamydophila pneumoniae - immunology</topic><topic>Coronary heart disease</topic><topic>EIA test</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Heart</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MIF test</topic><topic>Miscellaneous</topic><topic>Myocardial Infarction - immunology</topic><topic>Myocardial Infarction - microbiology</topic><topic>Risk Factors</topic><topic>Seroepidemiologic Studies</topic><topic>seroprevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halvorsen, D. S.</creatorcontrib><creatorcontrib>Børvik, T.</creatorcontrib><creatorcontrib>Njølstad, I.</creatorcontrib><creatorcontrib>Gutteberg, T. J.</creatorcontrib><creatorcontrib>Vorland, L. H.</creatorcontrib><creatorcontrib>Hansen, J.‐B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halvorsen, D. S.</au><au>Børvik, T.</au><au>Njølstad, I.</au><au>Gutteberg, T. J.</au><au>Vorland, L. H.</au><au>Hansen, J.‐B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2002-02</date><risdate>2002</risdate><volume>251</volume><issue>2</issue><spage>142</spage><epage>147</epage><pages>142-147</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>. Halvorsen DS, Børvik T, Njølstad I, Gutteberg TJ, Vorland LH, Hansen J‐B (University Hospital of Tromsø; and Institute of Community Medicine, Tromsø, Norway). Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence (MIF) test and an enzyme immunoassay (EIA). J Intern Med 2002; 251: 142–147.
Objectives. Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA‐ and IgG seroprevalence in young survivors of myocardial infarction and matched controls, and to compare the agreement of detecting antibodies between a MIF test and an enzyme immunoassay (EIA).
Design. A total of 61 patients hospitalized as a result of myocardial infarction, 51 patients hospitalized with chest pain and negative exercise‐ECG and 61 age and sex matched controls (mean age 53.3 years, range 40–60 years) were included in this case–control study. Serological comparisons were expressed as sensitivity, specificity and interrater agreement (K or Kw) of the EIA test related to the MIF test.
Results. Presence of IgA (cut off=16) antibodies was significantly higher in coronary heart patients compared with controls for both assays (P=0.02 by the MIF and P=0.05 by the EIA test). The presence of IgG (cut off=32) antibodies was significantly higher amongst patients (P=0.05) when analysed by the MIF‐test, but not with the EIA‐test (P=0.16). The strength of agreement between the assays was good for both IgA‐ (Kw=0.67) and IgG (Kw=0.79) analyses. However, only 52.8% of the IgA samples classified as strong positive (cut‐off=32) by the MIF test were strong positive by the EIA test (K=0.56). Only 73.2% of the negative IgG samples (<32) by the MIF‐test turned out negative by the EIA‐test (K=0.73).
Conclusions. Dependent on assay and cut‐off level, there is an increased C. pneumoniae IgA‐ and IgG seroprevalence in young survivors of myocardial infarction compared with controls. Despite the subjective interpretation of MIF‐titres, the strength of agreement between the EIA and MIF tests was good for both antibody classes. However, misclassification of highly positive IgA samples and negative IgG samples by the MIF test may influence study conclusions. We conclude that the choice of serological method is of major importance when evaluating a possible relationship between C. pneumoniae and coronary heart disease.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>11905590</pmid><doi>10.1046/j.1365-2796.2002.00942.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Bacterial diseases Biological and medical sciences Cardiology. Vascular system Case-Control Studies Chlamydia Infections - immunology Chlamydia Infections - microbiology Chlamydia pneumoniae antibodies Chlamydophila pneumoniae - immunology Coronary heart disease EIA test Female Fluorescent Antibody Technique Heart Human bacterial diseases Humans Immunoenzyme Techniques Immunoglobulin A - blood Immunoglobulin G - blood Infectious diseases Male Medical sciences Middle Aged MIF test Miscellaneous Myocardial Infarction - immunology Myocardial Infarction - microbiology Risk Factors Seroepidemiologic Studies seroprevalence |
| title | Chlamydia pneumoniae IgA‐ and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay |
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