Evaluation of Pluronic Polyols as Carriers for Grafting Materials: Study in Rat Calvaria Defects
Background: Pluronic polyols are a family of non‐ionic surfactants currently used as drug carriers for antibiotic, anti‐inflammatory, and anti‐neoplastic agents. Therapeutic administration of non‐ionic surface‐active agents is known to facilitate early collagen synthesis and microcirculation, thus p...
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| Veröffentlicht in: | Journal of periodontology (1970) 2002-02, Vol.73 (2), p.191-197 |
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| container_title | Journal of periodontology (1970) |
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| creator | Fowler, Edward B Cuenin, Michael F Hokett, Steven D Peacock, Mark E McPherson, James C Dirksen, Thomas R Sharawy, Mohamed Billman, Michael A |
| description | Background: Pluronic polyols are a family of non‐ionic surfactants currently used as drug carriers for antibiotic, anti‐inflammatory, and anti‐neoplastic agents. Therapeutic administration of non‐ionic surface‐active agents is known to facilitate early collagen synthesis and microcirculation, thus promoting wound healing. The purpose of this study was to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplast on the healing of critical‐sized calvarial defects.
Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague‐Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical‐sized defects were created. Pluronic F‐68 (F‐68) or pluronic F‐127 (F‐127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non‐grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy.
Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P |
| doi_str_mv | 10.1902/jop.2002.73.2.191 |
| format | Article |
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Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague‐Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical‐sized defects were created. Pluronic F‐68 (F‐68) or pluronic F‐127 (F‐127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non‐grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy.
Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P <0.05. The only significant difference within any of these groups was between the TCP control and TCP plus systemic F‐127, P <0.05.
Conclusions: Although there were isolated differences, the overall trend was that the pluronic polyol and the mode of administration did not result in a significant change in bone wound healing as measured by the percentage of bone fill. Pluronic polyols may be considered as carriers for osseous graft materials. J Periodontol 2002;73:191‐197.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2002.73.2.191</identifier><identifier>PMID: 11895285</identifier><language>eng</language><publisher>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA: American Academy of Periodontology</publisher><subject>Absorptiometry, Photon ; Analysis of Variance ; Animal studies ; Animals ; bone and bones ; Bone Diseases - diagnostic imaging ; Bone Diseases - pathology ; Bone Diseases - surgery ; Bone Substitutes - administration & dosage ; Bone Substitutes - therapeutic use ; Bone Transplantation - methods ; Calcium - analysis ; Calcium Phosphates - administration & dosage ; Calcium Phosphates - therapeutic use ; Dentistry ; Electron Probe Microanalysis ; Fluorescent Dyes ; grafts, bone ; Image Processing, Computer-Assisted ; Male ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Osteogenesis ; Phosphorus - analysis ; Poloxamer - chemistry ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Skull - diagnostic imaging ; Skull - pathology ; Skull - surgery ; Statistics as Topic ; surface active agents ; Surface-Active Agents - chemistry ; wound healing</subject><ispartof>Journal of periodontology (1970), 2002-02, Vol.73 (2), p.191-197</ispartof><rights>2002 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3451-9a06293c2705a3fa44ccfcfe6449d4689fd6f4aac3cf112e14b0dbded2c5a9873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1416,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11895285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fowler, Edward B</creatorcontrib><creatorcontrib>Cuenin, Michael F</creatorcontrib><creatorcontrib>Hokett, Steven D</creatorcontrib><creatorcontrib>Peacock, Mark E</creatorcontrib><creatorcontrib>McPherson, James C</creatorcontrib><creatorcontrib>Dirksen, Thomas R</creatorcontrib><creatorcontrib>Sharawy, Mohamed</creatorcontrib><creatorcontrib>Billman, Michael A</creatorcontrib><title>Evaluation of Pluronic Polyols as Carriers for Grafting Materials: Study in Rat Calvaria Defects</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: Pluronic polyols are a family of non‐ionic surfactants currently used as drug carriers for antibiotic, anti‐inflammatory, and anti‐neoplastic agents. Therapeutic administration of non‐ionic surface‐active agents is known to facilitate early collagen synthesis and microcirculation, thus promoting wound healing. The purpose of this study was to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplast on the healing of critical‐sized calvarial defects.
Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague‐Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical‐sized defects were created. Pluronic F‐68 (F‐68) or pluronic F‐127 (F‐127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non‐grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy.
Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P <0.05. The only significant difference within any of these groups was between the TCP control and TCP plus systemic F‐127, P <0.05.
Conclusions: Although there were isolated differences, the overall trend was that the pluronic polyol and the mode of administration did not result in a significant change in bone wound healing as measured by the percentage of bone fill. Pluronic polyols may be considered as carriers for osseous graft materials. J Periodontol 2002;73:191‐197.</description><subject>Absorptiometry, Photon</subject><subject>Analysis of Variance</subject><subject>Animal studies</subject><subject>Animals</subject><subject>bone and bones</subject><subject>Bone Diseases - diagnostic imaging</subject><subject>Bone Diseases - pathology</subject><subject>Bone Diseases - surgery</subject><subject>Bone Substitutes - administration & dosage</subject><subject>Bone Substitutes - therapeutic use</subject><subject>Bone Transplantation - methods</subject><subject>Calcium - analysis</subject><subject>Calcium Phosphates - administration & dosage</subject><subject>Calcium Phosphates - therapeutic use</subject><subject>Dentistry</subject><subject>Electron Probe Microanalysis</subject><subject>Fluorescent Dyes</subject><subject>grafts, bone</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microscopy, Fluorescence</subject><subject>Osteogenesis</subject><subject>Phosphorus - analysis</subject><subject>Poloxamer - chemistry</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skull - diagnostic imaging</subject><subject>Skull - pathology</subject><subject>Skull - surgery</subject><subject>Statistics as Topic</subject><subject>surface active agents</subject><subject>Surface-Active Agents - chemistry</subject><subject>wound healing</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EgvL4AVyQT9xS_EpSc0OlFBCIisfZbB0bGblxsRNQ_z2uWokjp9XufDPSDkKnlAypJOziMyyHjBA2rPmQ5RPdQQMqBS94VZNdNMgSK7iQ7AAdpvSZVyo42UcHlI5kyUblAL1PvsH30LnQ4mDxzPcxtE7jWfCr4BOGhMcQozMxYRsinkawnWs_8CN0Jjrw6RK_dH2zwq7Fz9Bl2n9DFvC1sUZ36Rjt2UyZk-08Qm83k9fxbfHwNL0bXz0UmouSFhJIxSTXrCYlcAtCaG21NZUQshHVSNqmsgJAc20pZYaKOWnmjWmYLkGOan6Ezje5yxi-epM6tXBJG--hNaFPqqb5YSlIBukG1DGkFI1Vy-gWEFeKErWuVeVa1bpWVXPF8olmz9k2vJ8vTPPn2PaYgXoD_DhvVv8nqvvZ5Jmso38BdZeFqw</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Fowler, Edward B</creator><creator>Cuenin, Michael F</creator><creator>Hokett, Steven D</creator><creator>Peacock, Mark E</creator><creator>McPherson, James C</creator><creator>Dirksen, Thomas R</creator><creator>Sharawy, Mohamed</creator><creator>Billman, Michael A</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200202</creationdate><title>Evaluation of Pluronic Polyols as Carriers for Grafting Materials: Study in Rat Calvaria Defects</title><author>Fowler, Edward B ; Cuenin, Michael F ; Hokett, Steven D ; Peacock, Mark E ; McPherson, James C ; Dirksen, Thomas R ; Sharawy, Mohamed ; Billman, Michael A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3451-9a06293c2705a3fa44ccfcfe6449d4689fd6f4aac3cf112e14b0dbded2c5a9873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Absorptiometry, Photon</topic><topic>Analysis of Variance</topic><topic>Animal studies</topic><topic>Animals</topic><topic>bone and bones</topic><topic>Bone Diseases - diagnostic imaging</topic><topic>Bone Diseases - pathology</topic><topic>Bone Diseases - surgery</topic><topic>Bone Substitutes - administration & dosage</topic><topic>Bone Substitutes - therapeutic use</topic><topic>Bone Transplantation - methods</topic><topic>Calcium - analysis</topic><topic>Calcium Phosphates - administration & dosage</topic><topic>Calcium Phosphates - therapeutic use</topic><topic>Dentistry</topic><topic>Electron Probe Microanalysis</topic><topic>Fluorescent Dyes</topic><topic>grafts, bone</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microscopy, Fluorescence</topic><topic>Osteogenesis</topic><topic>Phosphorus - analysis</topic><topic>Poloxamer - chemistry</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skull - diagnostic imaging</topic><topic>Skull - pathology</topic><topic>Skull - surgery</topic><topic>Statistics as Topic</topic><topic>surface active agents</topic><topic>Surface-Active Agents - chemistry</topic><topic>wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fowler, Edward B</creatorcontrib><creatorcontrib>Cuenin, Michael F</creatorcontrib><creatorcontrib>Hokett, Steven D</creatorcontrib><creatorcontrib>Peacock, Mark E</creatorcontrib><creatorcontrib>McPherson, James C</creatorcontrib><creatorcontrib>Dirksen, Thomas R</creatorcontrib><creatorcontrib>Sharawy, Mohamed</creatorcontrib><creatorcontrib>Billman, Michael A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fowler, Edward B</au><au>Cuenin, Michael F</au><au>Hokett, Steven D</au><au>Peacock, Mark E</au><au>McPherson, James C</au><au>Dirksen, Thomas R</au><au>Sharawy, Mohamed</au><au>Billman, Michael A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Pluronic Polyols as Carriers for Grafting Materials: Study in Rat Calvaria Defects</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2002-02</date><risdate>2002</risdate><volume>73</volume><issue>2</issue><spage>191</spage><epage>197</epage><pages>191-197</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: Pluronic polyols are a family of non‐ionic surfactants currently used as drug carriers for antibiotic, anti‐inflammatory, and anti‐neoplastic agents. Therapeutic administration of non‐ionic surface‐active agents is known to facilitate early collagen synthesis and microcirculation, thus promoting wound healing. The purpose of this study was to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplast on the healing of critical‐sized calvarial defects.
Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague‐Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical‐sized defects were created. Pluronic F‐68 (F‐68) or pluronic F‐127 (F‐127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non‐grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy.
Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P <0.05. The only significant difference within any of these groups was between the TCP control and TCP plus systemic F‐127, P <0.05.
Conclusions: Although there were isolated differences, the overall trend was that the pluronic polyol and the mode of administration did not result in a significant change in bone wound healing as measured by the percentage of bone fill. Pluronic polyols may be considered as carriers for osseous graft materials. J Periodontol 2002;73:191‐197.</abstract><cop>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA</cop><pub>American Academy of Periodontology</pub><pmid>11895285</pmid><doi>10.1902/jop.2002.73.2.191</doi><tpages>7</tpages></addata></record> |
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| subjects | Absorptiometry, Photon Analysis of Variance Animal studies Animals bone and bones Bone Diseases - diagnostic imaging Bone Diseases - pathology Bone Diseases - surgery Bone Substitutes - administration & dosage Bone Substitutes - therapeutic use Bone Transplantation - methods Calcium - analysis Calcium Phosphates - administration & dosage Calcium Phosphates - therapeutic use Dentistry Electron Probe Microanalysis Fluorescent Dyes grafts, bone Image Processing, Computer-Assisted Male Microscopy, Electron, Scanning Microscopy, Fluorescence Osteogenesis Phosphorus - analysis Poloxamer - chemistry Random Allocation Rats Rats, Sprague-Dawley Skull - diagnostic imaging Skull - pathology Skull - surgery Statistics as Topic surface active agents Surface-Active Agents - chemistry wound healing |
| title | Evaluation of Pluronic Polyols as Carriers for Grafting Materials: Study in Rat Calvaria Defects |
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