The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin

An acidic polysaccharide with anticoagulant activity was isolated from the edible mushroom Auricularia auricula using water, alkali or acid extracts. The alkali extract showed the highest anticoagulant activity and was thereby further purified using gel filtration chromatography. Specific anticoagul...

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Veröffentlicht in:	Thrombosis research 2003, Vol.112 (3), p.151-158
Hauptverfasser:	Yoon, Seon-Joo, Yu, Myeong-Ae, Pyun, Yu-Ryang, Hwang, Jae-Kwan, Chu, Djong-Chi, Juneja, Lekh Raj, Mourão, Paulo A.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulant Anticoagulants - isolation & purification Anticoagulants - pharmacology Antiplatelet Antithrombin Antithrombins - pharmacology Antithrombins - physiology Basidiomycota - chemistry Biological and medical sciences Blood Coagulation - drug effects Chromatography, Gel Fundamental and applied biological sciences. Psychology Hexuronic Acids - analysis Korea Male Monosaccharides - analysis Mushroom polysaccharide Partial Thromboplastin Time Plants, Edible Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology Prothrombin Time Rats Rats, Sprague-Dawley Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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