Stress in pregnancy: A new Wistar rat model for human preeclampsia
OBJECTIVE: Our study evaluated the effects of chronic and/or acute stress on pregnant and nonpregnant female rats. STUDY DESIGN: The rats were exposed to the sonic stimulus associated with overpopulation between days 7 and 14 of pregnancy. The rats were immobilized 2 days before the vascular reactiv...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2002-03, Vol.186 (3), p.544-550 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Takiuti, Nilton H. Kahhale, Soubhi Zugaib, Marcelo |
| description | OBJECTIVE: Our study evaluated the effects of chronic and/or acute stress on pregnant and nonpregnant female rats. STUDY DESIGN: The rats were exposed to the sonic stimulus associated with overpopulation between days 7 and 14 of pregnancy. The rats were immobilized 2 days before the vascular reactivity experiments. RESULTS: In 14-day pregnant rats, chronic stress led to lower weight, increased adrenal weight, lower endothelium-derived relaxing factor release, and lower fetal weight. In 20-day pregnant rats, chronic stress caused decreased weight gain, higher blood pressure, increased vasomotility and proteinuria, lower endothelium-derived relaxing factor release, and lower fetal weight. In the 20-day pregnant group, the higher adrenal weight resulted in higher blood pressure, lower vascular relaxation, and lower average fetal weight. A greater number of fetuses had higher adrenal weight, higher blood pressure, and lower vascular relaxation. CONCLUSION: The alterations found in the rats were similar to those that occur in human preeclampsia. Therefore, we propose a new animal model for human preeclampsia. (Am J Obstet Gynecol 2002;186:544-50.) |
| doi_str_mv | 10.1067/mob.2002.121102 |
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STUDY DESIGN: The rats were exposed to the sonic stimulus associated with overpopulation between days 7 and 14 of pregnancy. The rats were immobilized 2 days before the vascular reactivity experiments. RESULTS: In 14-day pregnant rats, chronic stress led to lower weight, increased adrenal weight, lower endothelium-derived relaxing factor release, and lower fetal weight. In 20-day pregnant rats, chronic stress caused decreased weight gain, higher blood pressure, increased vasomotility and proteinuria, lower endothelium-derived relaxing factor release, and lower fetal weight. In the 20-day pregnant group, the higher adrenal weight resulted in higher blood pressure, lower vascular relaxation, and lower average fetal weight. A greater number of fetuses had higher adrenal weight, higher blood pressure, and lower vascular relaxation. CONCLUSION: The alterations found in the rats were similar to those that occur in human preeclampsia. Therefore, we propose a new animal model for human preeclampsia. (Am J Obstet Gynecol 2002;186:544-50.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1067/mob.2002.121102</identifier><identifier>PMID: 11904621</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Acute Disease ; Adrenal Glands - pathology ; animal model ; Animals ; Biological and medical sciences ; Blood Pressure ; Body Weight ; Chronic Disease ; Disease Models, Animal ; Diseases of mother, fetus and pregnancy ; Female ; Fetal Weight ; Gynecology. Andrology. Obstetrics ; Medical sciences ; Nitric Oxide - metabolism ; Organ Size ; Pre-Eclampsia - etiology ; preeclampsia ; Pregnancy ; Pregnancy Complications ; Pregnancy. Fetus. 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STUDY DESIGN: The rats were exposed to the sonic stimulus associated with overpopulation between days 7 and 14 of pregnancy. The rats were immobilized 2 days before the vascular reactivity experiments. RESULTS: In 14-day pregnant rats, chronic stress led to lower weight, increased adrenal weight, lower endothelium-derived relaxing factor release, and lower fetal weight. In 20-day pregnant rats, chronic stress caused decreased weight gain, higher blood pressure, increased vasomotility and proteinuria, lower endothelium-derived relaxing factor release, and lower fetal weight. In the 20-day pregnant group, the higher adrenal weight resulted in higher blood pressure, lower vascular relaxation, and lower average fetal weight. A greater number of fetuses had higher adrenal weight, higher blood pressure, and lower vascular relaxation. CONCLUSION: The alterations found in the rats were similar to those that occur in human preeclampsia. Therefore, we propose a new animal model for human preeclampsia. (Am J Obstet Gynecol 2002;186:544-50.)</description><subject>Acute Disease</subject><subject>Adrenal Glands - pathology</subject><subject>animal model</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Weight</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Weight</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Medical sciences</subject><subject>Nitric Oxide - metabolism</subject><subject>Organ Size</subject><subject>Pre-Eclampsia - etiology</subject><subject>preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reference Values</subject><subject>Stress</subject><subject>Stress, Physiological - complications</subject><subject>Stress, Physiological - pathology</subject><subject>Stress, Physiological - physiopathology</subject><subject>Time Factors</subject><subject>Tropical medicine</subject><subject>vascular reactivity</subject><subject>Vasomotor System - physiopathology</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1PwyAYwHFiNG5Oz94MF71146Ut4G0uviVLPKjxSCh9qpi-TGg1-_Yyt2QnT4Tw4wn8ETqnZEpJLmZNV0wZIWxKGaWEHaAxJUokuczlIRqTeJIoLuQInYTwudkyxY7RiFJF0pzRMbp57j2EgF2LVx7eW9Pa9TWe4xZ-8JsLvfHYmx43XQk1rjqPP4bG_FmwtWlWwZlTdFSZOsDZbp2g17vbl8VDsny6f1zMl4nlgveJUGUmRMZNDiRXUuR88-LSFllWFpJUlLNKWZlKVYEqUkpk_FNRspRmjHBT8Am62s5d-e5rgNDrxgULdW1a6IagRYSSEhrhbAut70LwUOmVd43xa02J3mTTMZveZNPbbPHGxW70UDRQ7v2uUwSXO2CCNXXlYycX9o5nmVJ5Fp3aOoghvh14HayD1kLpPNhel5379xG_vFyGOg</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Takiuti, Nilton H.</creator><creator>Kahhale, Soubhi</creator><creator>Zugaib, Marcelo</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Stress in pregnancy: A new Wistar rat model for human preeclampsia</title><author>Takiuti, Nilton H. ; Kahhale, Soubhi ; Zugaib, Marcelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-79d57753a6e06987631102dcb55db80f132f9c8489fe9b4108121bd2415203ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Disease</topic><topic>Adrenal Glands - pathology</topic><topic>animal model</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Weight</topic><topic>Chronic Disease</topic><topic>Disease Models, Animal</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fetal Weight</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Medical sciences</topic><topic>Nitric Oxide - metabolism</topic><topic>Organ Size</topic><topic>Pre-Eclampsia - etiology</topic><topic>preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reference Values</topic><topic>Stress</topic><topic>Stress, Physiological - complications</topic><topic>Stress, Physiological - pathology</topic><topic>Stress, Physiological - physiopathology</topic><topic>Time Factors</topic><topic>Tropical medicine</topic><topic>vascular reactivity</topic><topic>Vasomotor System - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takiuti, Nilton H.</creatorcontrib><creatorcontrib>Kahhale, Soubhi</creatorcontrib><creatorcontrib>Zugaib, Marcelo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takiuti, Nilton H.</au><au>Kahhale, Soubhi</au><au>Zugaib, Marcelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stress in pregnancy: A new Wistar rat model for human preeclampsia</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>186</volume><issue>3</issue><spage>544</spage><epage>550</epage><pages>544-550</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>OBJECTIVE: Our study evaluated the effects of chronic and/or acute stress on pregnant and nonpregnant female rats. STUDY DESIGN: The rats were exposed to the sonic stimulus associated with overpopulation between days 7 and 14 of pregnancy. The rats were immobilized 2 days before the vascular reactivity experiments. RESULTS: In 14-day pregnant rats, chronic stress led to lower weight, increased adrenal weight, lower endothelium-derived relaxing factor release, and lower fetal weight. In 20-day pregnant rats, chronic stress caused decreased weight gain, higher blood pressure, increased vasomotility and proteinuria, lower endothelium-derived relaxing factor release, and lower fetal weight. In the 20-day pregnant group, the higher adrenal weight resulted in higher blood pressure, lower vascular relaxation, and lower average fetal weight. A greater number of fetuses had higher adrenal weight, higher blood pressure, and lower vascular relaxation. CONCLUSION: The alterations found in the rats were similar to those that occur in human preeclampsia. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acute Disease Adrenal Glands - pathology animal model Animals Biological and medical sciences Blood Pressure Body Weight Chronic Disease Disease Models, Animal Diseases of mother, fetus and pregnancy Female Fetal Weight Gynecology. Andrology. Obstetrics Medical sciences Nitric Oxide - metabolism Organ Size Pre-Eclampsia - etiology preeclampsia Pregnancy Pregnancy Complications Pregnancy. Fetus. Placenta rat Rats Rats, Wistar Reference Values Stress Stress, Physiological - complications Stress, Physiological - pathology Stress, Physiological - physiopathology Time Factors Tropical medicine vascular reactivity Vasomotor System - physiopathology |
| title | Stress in pregnancy: A new Wistar rat model for human preeclampsia |
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