µ/δ Cooperativity and opposing κ-opioid effects in nucleus accumbens-mediated antinociception in the rat

We previously demonstrated that noxious peripheral stimulation (e.g. subdermal capsaicin injection in the hind paw) produces antinociception that is mediated by opioid receptors in nucleus accumbens. The current study used the trigeminal jaw‐opening nociceptive reflex responses in the rat to assess...

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Veröffentlicht in:	The European journal of neuroscience 2002-03, Vol.15 (5), p.861-868
Hauptverfasser:	Schmidt, Brian L., Tambeli, Claudia H., Levine, Jon D., Gear, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	analgesia Analgesics, Opioid - pharmacology Animals Benzeneacetamides Capsaicin - pharmacology Enkephalin, Ala-MePhe-Gly- - pharmacology Enkephalin, D-Penicillamine (2,5)- - pharmacology Male mesolimbic dopaminergic system Narcotic Antagonists - pharmacology Neurons - drug effects Neurons - metabolism Nociceptors - drug effects Nociceptors - metabolism Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism pain Pain - drug therapy Pain - metabolism Pain - physiopathology Pyrrolidines - pharmacology Rats Receptors, Opioid, delta - drug effects Receptors, Opioid, delta - metabolism Receptors, Opioid, kappa - drug effects Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism Reflex - drug effects Reflex - physiology δ-opioid receptor κ-opioid receptor µ-opioid receptor
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