The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance

Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle....

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-03, Vol.295 (5562), p.2073-2076
Hauptverfasser:	Azevedo, Cristina, Sadanandom, Ari, Kitagawa, Katsumi, Freialdenhoven, Andreas, Shirasu, Ken, Schulze-Lefert, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Agronomy. Soil science and plant productions Amino Acid Motifs Amino Acid Sequence Antibodies Arabidopsis - chemistry Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Barley Biological and medical sciences Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells COP9 Signalosome Complex CUL1 protein Disease Disease resistance Diseases and pests Epidermal cells Flowers & plants Fundamental and applied biological sciences. Psychology Gene Silencing Genes Genes, Fungal Genes, Plant Genetic aspects Genetics and breeding of economic plants Hordeum - chemistry Hordeum - genetics Hordeum - metabolism Hordeum vulgare Immune response Immunity, Innate Literary Devices Maximum likelihood estimation Mildews Molecular biology Molecular Sequence Data Multiprotein Complexes Peptide Hydrolases Peptide Synthases - metabolism Pest resistance Plant Diseases Plant pathogens Plant Proteins - genetics Plant Proteins - metabolism Plants Plants (Organisms) Population size Protein Structure, Tertiary Proteins Proteins - metabolism R genes Rar1 gene Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment Sgt1 gene Signal Transduction SKP Cullin F-Box Protein Ligases SKP1 protein Statistical variance Two-Hybrid System Techniques Ubiquitin - metabolism ubiquitin ligase ubiquitination Ubiquitins Varietal selection. Specialized plant breeding, plant breeding aims Yeast Yeasts
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Zusammenfassung:	Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1067554