MALARIA-ASSOCIATED CYTOKINE CHANGES IN THE PLACENTA OF WOMEN WITH PRE-TERM DELIVERIES IN YAOUNDE, CAMEROON
The prevalence of pre-term deliveries (PTDs) is increased in women who become infected with Plasmodium falciparum during pregnancy. Because prematurity is a risk factor for newborns, it is important to identify conditions that contribute to malaria-associated PTDs. Plasmodium falciparum-infected ery...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2003-12, Vol.69 (6), p.574-581 |
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| creator | SUGUITAN, AMORSOLO L., JR CADIGAN, TIMOTHY J NGUYEN, THU A ZHOU, AINONG LEKE, ROBERT J. I METENOU, SIMON THUITA, LUCY MEGNEKOU, ROSETTE FOGAKO, JOSEPHINE LEKE, ROSE G. F TAYLOR, DIANE WALLACE |
| description | The prevalence of pre-term deliveries (PTDs) is increased in women who become infected with Plasmodium falciparum during pregnancy. Because prematurity is a risk factor for newborns, it is important to identify conditions that contribute to malaria-associated PTDs. Plasmodium falciparum-infected erythrocytes sequester in the placenta and attract activated mononuclear cells that secrete pro-inflammatory cytokines. Increased inflammatory cytokine levels in other microbial infections are associated with PTDs. To determine if such is the case in women with placental malaria, concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and IL-10 were measured in placental plasma of 391 malaria-infected and -uninfected Cameroonian women with premature and full-term deliveries. Risk factors for malaria-associated PTDs included peripheral and placental parasitemias greater than 1%, maternal anemia, elevated IL-10 levels, and low TNF-alpha:IL-10 ratios due to over-expression of IL-10. Alterations in cytokine levels may contribute to PTDs through the induction of anemia and/or altering cellular immune responses required for eliminating placental parasites. |
| doi_str_mv | 10.4269/ajtmh.2003.69.574 |
| format | Article |
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To determine if such is the case in women with placental malaria, concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and IL-10 were measured in placental plasma of 391 malaria-infected and -uninfected Cameroonian women with premature and full-term deliveries. Risk factors for malaria-associated PTDs included peripheral and placental parasitemias greater than 1%, maternal anemia, elevated IL-10 levels, and low TNF-alpha:IL-10 ratios due to over-expression of IL-10. Alterations in cytokine levels may contribute to PTDs through the induction of anemia and/or altering cellular immune responses required for eliminating placental parasites.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2003.69.574</identifier><identifier>PMID: 14740871</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Adult ; Animals ; Biological and medical sciences ; Cameroon ; Case-Control Studies ; Cytokines - immunology ; Delivery. Postpartum. Lactation ; Enzyme-Linked Immunosorbent Assay ; Female ; Gynecology. Andrology. Obstetrics ; Human protozoal diseases ; Humans ; Infectious diseases ; Malaria ; Malaria, Falciparum - immunology ; Malaria, Falciparum - parasitology ; Medical sciences ; Obstetric Labor, Premature ; Parasitic diseases ; Placenta - immunology ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; Pregnancy ; Pregnancy Complications, Parasitic - immunology ; Pregnancy Complications, Parasitic - parasitology ; Protozoal diseases</subject><ispartof>The American journal of tropical medicine and hygiene, 2003-12, Vol.69 (6), p.574-581</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-66f5e2fcd9ba6f539204398a48703ceaf9b803db09b70c85d1c9f41a13c408aa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15394341$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14740871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUGUITAN, AMORSOLO L., JR</creatorcontrib><creatorcontrib>CADIGAN, TIMOTHY J</creatorcontrib><creatorcontrib>NGUYEN, THU A</creatorcontrib><creatorcontrib>ZHOU, AINONG</creatorcontrib><creatorcontrib>LEKE, ROBERT J. 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Increased inflammatory cytokine levels in other microbial infections are associated with PTDs. To determine if such is the case in women with placental malaria, concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and IL-10 were measured in placental plasma of 391 malaria-infected and -uninfected Cameroonian women with premature and full-term deliveries. Risk factors for malaria-associated PTDs included peripheral and placental parasitemias greater than 1%, maternal anemia, elevated IL-10 levels, and low TNF-alpha:IL-10 ratios due to over-expression of IL-10. Alterations in cytokine levels may contribute to PTDs through the induction of anemia and/or altering cellular immune responses required for eliminating placental parasites.</description><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cameroon</subject><subject>Case-Control Studies</subject><subject>Cytokines - immunology</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Medical sciences</subject><subject>Obstetric Labor, Premature</subject><subject>Parasitic diseases</subject><subject>Placenta - immunology</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - immunology</subject><subject>Pregnancy Complications, Parasitic - parasitology</subject><subject>Protozoal diseases</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTFv2zAQhYmiReOm_QFdCi7NVLmkSFHiSMhMLESWAllpkImgaKqWIcWpaMPovw9jG0i3TncHfPcO7x4AXzGa0pDxn3qzG9bTECEyZXwaxfQdmGAaswAzGr0HE4RQGHBG4gvwybkNQjgJMf4ILjxEURLjCdgsRC6qTARiuSzTTNRyBtPHurzNCgnTuShu5BJmBaznEt7lIpVFLWB5DR_KhSzgQ1bP4V0lg1pWCziTefZLVtlp41GU98VM_oCpWMiqLIvP4EOre2e_nOsluL-WdToP8vImS0UeGErILmCsjWzYmhVvtG8JDxElPNE0iRExVre8SRBZNYg3MTJJtMKGtxRrTIz3pDW5BFcn3edx-2dv3U4NnTO27_WT3e6dinEUMv-A_4I45pRjFHkQn0Azbp0bbauex27Q41-FkXpNQh2TUK9JKD9FR_FvZ_F9M9jV28b59R74fga0M7pvR_1kOvfGeeeU0H-4dfd7fehGq9yg-97LYnU4HPw5djz4AipBlWg</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>SUGUITAN, AMORSOLO L., JR</creator><creator>CADIGAN, TIMOTHY J</creator><creator>NGUYEN, THU A</creator><creator>ZHOU, AINONG</creator><creator>LEKE, ROBERT J. 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Obstetrics</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Medical sciences</topic><topic>Obstetric Labor, Premature</topic><topic>Parasitic diseases</topic><topic>Placenta - immunology</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - immunology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - immunology</topic><topic>Pregnancy Complications, Parasitic - parasitology</topic><topic>Protozoal diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUGUITAN, AMORSOLO L., JR</creatorcontrib><creatorcontrib>CADIGAN, TIMOTHY J</creatorcontrib><creatorcontrib>NGUYEN, THU A</creatorcontrib><creatorcontrib>ZHOU, AINONG</creatorcontrib><creatorcontrib>LEKE, ROBERT J. 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Increased inflammatory cytokine levels in other microbial infections are associated with PTDs. To determine if such is the case in women with placental malaria, concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and IL-10 were measured in placental plasma of 391 malaria-infected and -uninfected Cameroonian women with premature and full-term deliveries. Risk factors for malaria-associated PTDs included peripheral and placental parasitemias greater than 1%, maternal anemia, elevated IL-10 levels, and low TNF-alpha:IL-10 ratios due to over-expression of IL-10. Alterations in cytokine levels may contribute to PTDs through the induction of anemia and/or altering cellular immune responses required for eliminating placental parasites.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>14740871</pmid><doi>10.4269/ajtmh.2003.69.574</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Animals Biological and medical sciences Cameroon Case-Control Studies Cytokines - immunology Delivery. Postpartum. Lactation Enzyme-Linked Immunosorbent Assay Female Gynecology. Andrology. Obstetrics Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Medical sciences Obstetric Labor, Premature Parasitic diseases Placenta - immunology Plasmodium falciparum Plasmodium falciparum - immunology Pregnancy Pregnancy Complications, Parasitic - immunology Pregnancy Complications, Parasitic - parasitology Protozoal diseases |
| title | MALARIA-ASSOCIATED CYTOKINE CHANGES IN THE PLACENTA OF WOMEN WITH PRE-TERM DELIVERIES IN YAOUNDE, CAMEROON |
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