Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men
Trans monounsaturated fatty acids (TFA) are hypercholesterolemic compared to oleic acid to a degree approaching or equivalent to saturated FA. However, it is unknown to what extent these effects may be due to cholesterol lowering by oleic acid rather than elevation by saturated FA and TFA. In order...
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| Veröffentlicht in: | Lipids 2002-02, Vol.37 (2), p.123-131 |
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| creator | Judd, Joseph T. Baer, David J. Clevidence, Beverly A. Kris‐Etherton, Penny Muesing, Richard A. Iwane, Marika |
| description | Trans monounsaturated fatty acids (TFA) are hypercholesterolemic compared to oleic acid to a degree approaching or equivalent to saturated FA. However, it is unknown to what extent these effects may be due to cholesterol lowering by oleic acid rather than elevation by saturated FA and TFA. In order to better understand the impact of replacing TFA in foods, it is first necessary to know the relative lipid‐modifying effects of the major FA that change as TFA are lowered or removed. For 5 wk, 50 normocholesterolemic men were fed controlled diets providing approximately 15% of energy from protein, 39% from fat, and 46% from carbohydrate in a randomized, 6×6, crossover design. Eight percent of energy was replaced across diets with the following: carbohydrate (CHO) (1∶1 simple to complex); oleic acid (OL); TFA; stearic acid (STE); TFA/STE (4% of energy from each); carbon 12∶0 16∶0 saturated FA (LMP). LDL cholesterol concentrations (mmol/l) were as follows (different superscripts indicate significance at P≤0.01): OL 2.95a; CHO 3.05a,b; STE 3.10b,c; LMP 3.21c,d; TFA+STE 3.32d,e; and TFA 3.36e. HDL cholesterol concentrations (mmol/L) were as allows: STE 1.16a; IFA 1.16a,b; TFA/STE 1.17a,b; CHO 1.19b; OL 1.24c; and LMP 1.30d. Triacylglycerides were highest after STE (1.13) and lowest after OL (0.88) (P |
| doi_str_mv | 10.1007/s11745-002-0871-9 |
| format | Article |
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However, it is unknown to what extent these effects may be due to cholesterol lowering by oleic acid rather than elevation by saturated FA and TFA. In order to better understand the impact of replacing TFA in foods, it is first necessary to know the relative lipid‐modifying effects of the major FA that change as TFA are lowered or removed. For 5 wk, 50 normocholesterolemic men were fed controlled diets providing approximately 15% of energy from protein, 39% from fat, and 46% from carbohydrate in a randomized, 6×6, crossover design. Eight percent of energy was replaced across diets with the following: carbohydrate (CHO) (1∶1 simple to complex); oleic acid (OL); TFA; stearic acid (STE); TFA/STE (4% of energy from each); carbon 12∶0 16∶0 saturated FA (LMP). LDL cholesterol concentrations (mmol/l) were as follows (different superscripts indicate significance at P≤0.01): OL 2.95a; CHO 3.05a,b; STE 3.10b,c; LMP 3.21c,d; TFA+STE 3.32d,e; and TFA 3.36e. HDL cholesterol concentrations (mmol/L) were as allows: STE 1.16a; IFA 1.16a,b; TFA/STE 1.17a,b; CHO 1.19b; OL 1.24c; and LMP 1.30d. Triacylglycerides were highest after STE (1.13) and lowest after OL (0.88) (P<0.001). Thus, compared to the carbohydrate control diet, TFA raised LDL cholesterol at least equivalent to LMP but had no effect on HDI cholesterol; STE had no effect on LDL cholesterol but lowered HDL cholesterol; LMP raised both LDL cholesterol and HDL cholesterol; and oleic acid raised HDL cholesterol but had no effect on LDL cholesterol.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-002-0871-9</identifier><identifier>PMID: 11908904</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Carbohydrates ; Cholesterol ; Cross-Over Studies ; Diet ; Dietary Fats - administration & dosage ; Dietary Fats, Unsaturated - administration & dosage ; Energy Intake ; Fatty acids ; Humans ; Lipids ; Lipids - blood ; Lipids - classification ; Lipoproteins - blood ; Lipoproteins - classification ; Male</subject><ispartof>Lipids, 2002-02, Vol.37 (2), p.123-131</ispartof><rights>2002 American Oil Chemists' Society (AOCS)</rights><rights>AOCS Press 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4383-98e6ee7ba5f01e2227c913a2a352e192101fc7027b63cb54662de07225328bd13</citedby><cites>FETCH-LOGICAL-c4383-98e6ee7ba5f01e2227c913a2a352e192101fc7027b63cb54662de07225328bd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-002-0871-9$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-002-0871-9$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11908904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Judd, Joseph T.</creatorcontrib><creatorcontrib>Baer, David J.</creatorcontrib><creatorcontrib>Clevidence, Beverly A.</creatorcontrib><creatorcontrib>Kris‐Etherton, Penny</creatorcontrib><creatorcontrib>Muesing, Richard A.</creatorcontrib><creatorcontrib>Iwane, Marika</creatorcontrib><title>Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men</title><title>Lipids</title><addtitle>Lipids</addtitle><description>Trans monounsaturated fatty acids (TFA) are hypercholesterolemic compared to oleic acid to a degree approaching or equivalent to saturated FA. However, it is unknown to what extent these effects may be due to cholesterol lowering by oleic acid rather than elevation by saturated FA and TFA. In order to better understand the impact of replacing TFA in foods, it is first necessary to know the relative lipid‐modifying effects of the major FA that change as TFA are lowered or removed. For 5 wk, 50 normocholesterolemic men were fed controlled diets providing approximately 15% of energy from protein, 39% from fat, and 46% from carbohydrate in a randomized, 6×6, crossover design. Eight percent of energy was replaced across diets with the following: carbohydrate (CHO) (1∶1 simple to complex); oleic acid (OL); TFA; stearic acid (STE); TFA/STE (4% of energy from each); carbon 12∶0 16∶0 saturated FA (LMP). LDL cholesterol concentrations (mmol/l) were as follows (different superscripts indicate significance at P≤0.01): OL 2.95a; CHO 3.05a,b; STE 3.10b,c; LMP 3.21c,d; TFA+STE 3.32d,e; and TFA 3.36e. HDL cholesterol concentrations (mmol/L) were as allows: STE 1.16a; IFA 1.16a,b; TFA/STE 1.17a,b; CHO 1.19b; OL 1.24c; and LMP 1.30d. Triacylglycerides were highest after STE (1.13) and lowest after OL (0.88) (P<0.001). Thus, compared to the carbohydrate control diet, TFA raised LDL cholesterol at least equivalent to LMP but had no effect on HDI cholesterol; STE had no effect on LDL cholesterol but lowered HDL cholesterol; LMP raised both LDL cholesterol and HDL cholesterol; and oleic acid raised HDL cholesterol but had no effect on LDL cholesterol.</description><subject>Carbohydrates</subject><subject>Cholesterol</subject><subject>Cross-Over Studies</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats, Unsaturated - administration & dosage</subject><subject>Energy Intake</subject><subject>Fatty acids</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipids - classification</subject><subject>Lipoproteins - blood</subject><subject>Lipoproteins - classification</subject><subject>Male</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkE1LxDAQhoMo7vrxA7xI8eCtOpM0TXIUv2FBD3qOaTsLWfqxNi3ivze7XRC8eEom88w74WHsDOEKAdR1QFSZTAF4ClphavbYHKXUqRGg9tk8NrI044AzdhTCKpaYGXnIZogGtIFszj7uPA2u_05KHxLXVsnQuzYkTdd2YxvcMPZuoGrb-a0ebrYP69qFxiW1X_tqGo7Xbt13A_mY4dukofaEHSxdHeh0dx6z94f7t9undPHy-Hx7s0jLTGiRGk05kSqcXAIS51yVBoXjTkhOaDgCLksFXBW5KAuZ5TmvCBTnUnBdVCiO2eWUG_d_jhQG2_hQUl27lroxWIWS51zrCF78AVfd2Lfxb1ZrjSITCiKEE1T2XQg9Le269030ZBHsxr2d3Nvo1G7cWxNnznfBY9FQ9Tuxkx0BNQFfvqbv_xPt4vn1DpAL8QMBdI5e</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Judd, Joseph T.</creator><creator>Baer, David J.</creator><creator>Clevidence, Beverly A.</creator><creator>Kris‐Etherton, Penny</creator><creator>Muesing, Richard A.</creator><creator>Iwane, Marika</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200202</creationdate><title>Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men</title><author>Judd, Joseph T. ; Baer, David J. ; Clevidence, Beverly A. ; Kris‐Etherton, Penny ; Muesing, Richard A. ; Iwane, Marika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4383-98e6ee7ba5f01e2227c913a2a352e192101fc7027b63cb54662de07225328bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Carbohydrates</topic><topic>Cholesterol</topic><topic>Cross-Over Studies</topic><topic>Diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats, Unsaturated - administration & dosage</topic><topic>Energy Intake</topic><topic>Fatty acids</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipids - classification</topic><topic>Lipoproteins - blood</topic><topic>Lipoproteins - classification</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Judd, Joseph T.</creatorcontrib><creatorcontrib>Baer, David J.</creatorcontrib><creatorcontrib>Clevidence, Beverly A.</creatorcontrib><creatorcontrib>Kris‐Etherton, Penny</creatorcontrib><creatorcontrib>Muesing, Richard A.</creatorcontrib><creatorcontrib>Iwane, Marika</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Judd, Joseph T.</au><au>Baer, David J.</au><au>Clevidence, Beverly A.</au><au>Kris‐Etherton, Penny</au><au>Muesing, Richard A.</au><au>Iwane, Marika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2002-02</date><risdate>2002</risdate><volume>37</volume><issue>2</issue><spage>123</spage><epage>131</epage><pages>123-131</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Trans monounsaturated fatty acids (TFA) are hypercholesterolemic compared to oleic acid to a degree approaching or equivalent to saturated FA. However, it is unknown to what extent these effects may be due to cholesterol lowering by oleic acid rather than elevation by saturated FA and TFA. In order to better understand the impact of replacing TFA in foods, it is first necessary to know the relative lipid‐modifying effects of the major FA that change as TFA are lowered or removed. For 5 wk, 50 normocholesterolemic men were fed controlled diets providing approximately 15% of energy from protein, 39% from fat, and 46% from carbohydrate in a randomized, 6×6, crossover design. Eight percent of energy was replaced across diets with the following: carbohydrate (CHO) (1∶1 simple to complex); oleic acid (OL); TFA; stearic acid (STE); TFA/STE (4% of energy from each); carbon 12∶0 16∶0 saturated FA (LMP). LDL cholesterol concentrations (mmol/l) were as follows (different superscripts indicate significance at P≤0.01): OL 2.95a; CHO 3.05a,b; STE 3.10b,c; LMP 3.21c,d; TFA+STE 3.32d,e; and TFA 3.36e. HDL cholesterol concentrations (mmol/L) were as allows: STE 1.16a; IFA 1.16a,b; TFA/STE 1.17a,b; CHO 1.19b; OL 1.24c; and LMP 1.30d. Triacylglycerides were highest after STE (1.13) and lowest after OL (0.88) (P<0.001). Thus, compared to the carbohydrate control diet, TFA raised LDL cholesterol at least equivalent to LMP but had no effect on HDI cholesterol; STE had no effect on LDL cholesterol but lowered HDL cholesterol; LMP raised both LDL cholesterol and HDL cholesterol; and oleic acid raised HDL cholesterol but had no effect on LDL cholesterol.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>11908904</pmid><doi>10.1007/s11745-002-0871-9</doi><tpages>9</tpages></addata></record> |
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| subjects | Carbohydrates Cholesterol Cross-Over Studies Diet Dietary Fats - administration & dosage Dietary Fats, Unsaturated - administration & dosage Energy Intake Fatty acids Humans Lipids Lipids - blood Lipids - classification Lipoproteins - blood Lipoproteins - classification Male |
| title | Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men |
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