Role of nitric oxide and β-adrenoceptors of the central nervous system on the salivary flow induced by pilocarpine injection into the lateral ventricle
Our studies have focused on the effect of l- NG-nitroarginine methyl ester ( l-NAME), an inhibitor of nitric oxide synthase (NOS), and l-arginine, the substrate of NOS, on salivary secretion induced by the administration of pilocarpine into the lateral cerebral ventricle (LV) of rats. The present st...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-05, Vol.72 (1), p.229-235 |
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| creator | Saad, Wilson Abrão Motta Siqueira Guarda, Ismael Francisco Saad Guarda, Renata de Arruda Camargo, Luis Antonio Brisola dos Santos, Talmir Augusto Faria Saad, William Abrão Simões, Sylvio |
| description | Our studies have focused on the effect of
l-
NG-nitroarginine methyl ester (
l-NAME), an inhibitor of nitric oxide synthase (NOS), and
l-arginine, the substrate of NOS, on salivary secretion induced by the administration of pilocarpine into the lateral cerebral ventricle (LV) of rats. The present study has also investigated the role of the β-adrenergic agonists and antagonist injected into LV on the salivary secretion elicited by the injection of pilocarpine into LV. Male Holtzman rats with a stainless-steel cannula implanted into the LV were used. The amount of salivary secretion was studied over a 7-min period after injection of pilocarpine, isoproterenol, propranolol, salbutamol, salmeterol,
l-NAME and
l-arginine. The injection of pilocarpine (10, 20, 40, 80 and 160 μg/μl) into LV produced a dose-dependent increase in salivary secretion. The injection of
l-NAME (40 μg/μl) into LV alone produced an increase in salivary secretion. The injection of
l-NAME into LV previous to the injection of pilocarpine produced an increase in salivary secretion.
l-Arginine (30 μg/μl) injected alone into LV produced no change in salivary secretion.
l-Arginine injected into LV attenuated pilocarpine-induced salivary secretion. The isoproterenol (40 nmol/μl) injected into LV increased the salivary secretion. When injected previous to pilocarpine at a dose of 20 and 40 μg/μl, isoproterenol produced an additive effect on pilocarpine-induced salivary secretion. The 40-nmol/μl dose of propranolol injected alone or previous to pilocarpine into LV attenuated the pilocarpine-induced salivary secretion. The injection of salbutamol (40 nmol/μl), a specific β-2 agonist, injected alone into LV produced no change in salivary secretion and when injected previous to pilocarpine produced an increase in salivary secretion. The 40-nmol/μl dose of salmeterol, a long-acting β-2 agonist, injected into LV alone or previous to pilocarpine produced no change in salivary secretion. The results have shown that central injections of
l-NAME and
l-arginine interfere with the salivary secretion, which implies that might participate in pilocarpine-induced salivary secretion. The interaction between cholinergic and β-adrenergic receptors of the central nervous system (CNS) for the control of salivary secretion can also be postulated. |
| doi_str_mv | 10.1016/S0091-3057(01)00760-2 |
| format | Article |
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l-
NG-nitroarginine methyl ester (
l-NAME), an inhibitor of nitric oxide synthase (NOS), and
l-arginine, the substrate of NOS, on salivary secretion induced by the administration of pilocarpine into the lateral cerebral ventricle (LV) of rats. The present study has also investigated the role of the β-adrenergic agonists and antagonist injected into LV on the salivary secretion elicited by the injection of pilocarpine into LV. Male Holtzman rats with a stainless-steel cannula implanted into the LV were used. The amount of salivary secretion was studied over a 7-min period after injection of pilocarpine, isoproterenol, propranolol, salbutamol, salmeterol,
l-NAME and
l-arginine. The injection of pilocarpine (10, 20, 40, 80 and 160 μg/μl) into LV produced a dose-dependent increase in salivary secretion. The injection of
l-NAME (40 μg/μl) into LV alone produced an increase in salivary secretion. The injection of
l-NAME into LV previous to the injection of pilocarpine produced an increase in salivary secretion.
l-Arginine (30 μg/μl) injected alone into LV produced no change in salivary secretion.
l-Arginine injected into LV attenuated pilocarpine-induced salivary secretion. The isoproterenol (40 nmol/μl) injected into LV increased the salivary secretion. When injected previous to pilocarpine at a dose of 20 and 40 μg/μl, isoproterenol produced an additive effect on pilocarpine-induced salivary secretion. The 40-nmol/μl dose of propranolol injected alone or previous to pilocarpine into LV attenuated the pilocarpine-induced salivary secretion. The injection of salbutamol (40 nmol/μl), a specific β-2 agonist, injected alone into LV produced no change in salivary secretion and when injected previous to pilocarpine produced an increase in salivary secretion. The 40-nmol/μl dose of salmeterol, a long-acting β-2 agonist, injected into LV alone or previous to pilocarpine produced no change in salivary secretion. The results have shown that central injections of
l-NAME and
l-arginine interfere with the salivary secretion, which implies that might participate in pilocarpine-induced salivary secretion. The interaction between cholinergic and β-adrenergic receptors of the central nervous system (CNS) for the control of salivary secretion can also be postulated.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(01)00760-2</identifier><identifier>PMID: 11900793</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Central Nervous System - drug effects ; Central Nervous System - physiology ; CNS ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Injections, Intraventricular ; Lateral Ventricles - drug effects ; Lateral Ventricles - metabolism ; Male ; Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus ; Nitric oxide ; Nitric Oxide - physiology ; Pilocarpine ; Pilocarpine - administration & dosage ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, beta - physiology ; Saliva - drug effects ; Saliva - metabolism ; Salivary secretion ; Vertebrates: digestive system ; β-adrenoceptors</subject><ispartof>Pharmacology, biochemistry and behavior, 2002-05, Vol.72 (1), p.229-235</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-59e8b28dd367376973398bd685c925b762b69530bdd01e6f4394035154b146d93</citedby><cites>FETCH-LOGICAL-c391t-59e8b28dd367376973398bd685c925b762b69530bdd01e6f4394035154b146d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(01)00760-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14546157$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11900793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saad, Wilson Abrão</creatorcontrib><creatorcontrib>Motta Siqueira Guarda, Ismael Francisco</creatorcontrib><creatorcontrib>Saad Guarda, Renata</creatorcontrib><creatorcontrib>de Arruda Camargo, Luis Antonio</creatorcontrib><creatorcontrib>Brisola dos Santos, Talmir Augusto Faria</creatorcontrib><creatorcontrib>Saad, William Abrão</creatorcontrib><creatorcontrib>Simões, Sylvio</creatorcontrib><title>Role of nitric oxide and β-adrenoceptors of the central nervous system on the salivary flow induced by pilocarpine injection into the lateral ventricle</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Our studies have focused on the effect of
l-
NG-nitroarginine methyl ester (
l-NAME), an inhibitor of nitric oxide synthase (NOS), and
l-arginine, the substrate of NOS, on salivary secretion induced by the administration of pilocarpine into the lateral cerebral ventricle (LV) of rats. The present study has also investigated the role of the β-adrenergic agonists and antagonist injected into LV on the salivary secretion elicited by the injection of pilocarpine into LV. Male Holtzman rats with a stainless-steel cannula implanted into the LV were used. The amount of salivary secretion was studied over a 7-min period after injection of pilocarpine, isoproterenol, propranolol, salbutamol, salmeterol,
l-NAME and
l-arginine. The injection of pilocarpine (10, 20, 40, 80 and 160 μg/μl) into LV produced a dose-dependent increase in salivary secretion. The injection of
l-NAME (40 μg/μl) into LV alone produced an increase in salivary secretion. The injection of
l-NAME into LV previous to the injection of pilocarpine produced an increase in salivary secretion.
l-Arginine (30 μg/μl) injected alone into LV produced no change in salivary secretion.
l-Arginine injected into LV attenuated pilocarpine-induced salivary secretion. The isoproterenol (40 nmol/μl) injected into LV increased the salivary secretion. When injected previous to pilocarpine at a dose of 20 and 40 μg/μl, isoproterenol produced an additive effect on pilocarpine-induced salivary secretion. The 40-nmol/μl dose of propranolol injected alone or previous to pilocarpine into LV attenuated the pilocarpine-induced salivary secretion. The injection of salbutamol (40 nmol/μl), a specific β-2 agonist, injected alone into LV produced no change in salivary secretion and when injected previous to pilocarpine produced an increase in salivary secretion. The 40-nmol/μl dose of salmeterol, a long-acting β-2 agonist, injected into LV alone or previous to pilocarpine produced no change in salivary secretion. The results have shown that central injections of
l-NAME and
l-arginine interfere with the salivary secretion, which implies that might participate in pilocarpine-induced salivary secretion. The interaction between cholinergic and β-adrenergic receptors of the central nervous system (CNS) for the control of salivary secretion can also be postulated.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System - drug effects</subject><subject>Central Nervous System - physiology</subject><subject>CNS</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraventricular</subject><subject>Lateral Ventricles - drug effects</subject><subject>Lateral Ventricles - metabolism</subject><subject>Male</subject><subject>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - physiology</subject><subject>Pilocarpine</subject><subject>Pilocarpine - administration & dosage</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Adrenergic, beta - physiology</subject><subject>Saliva - drug effects</subject><subject>Saliva - metabolism</subject><subject>Salivary secretion</subject><subject>Vertebrates: digestive system</subject><subject>β-adrenoceptors</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhYnROD2jj6BhoxkXpVAU0KwmZuJfMomJP2tCwa3IhIYS6NZ-E5_DB_GZpLo7ztIVCXzncO85CD2h5CUlVLz6TIiiHSNcXhL6ghApSNffQyu6lqzjVMr7aPUPOUPnpdwSQoZeyIfojFLVFIqt0K9PKQBOE46-Zm9x-ukdYBMd_vO7My5DTBbmmnJZoPoNsIVYswk4Qt6lbcFlXypscIqH12KC35m8x1NIP7CPbmvB4XGPZx-SNXn2Edr1Ldjqm8THmg66YCosrrvF3dsAj9CDyYQCj0_nBfr69s2X6_fdzcd3H65f33SWKVo7rmA99mvnmJBMCiUZU-vRiTW3quejFP0oFGdkdI5QENPA1EAYp3wY6SCcYhfo-dF3zun7FkrVG18shGAitPW0pLznSpAG8iNocyolw6Tn7DdtVU2JXirRh0r0krcmVB8q0X3TPT19sB034O5Upw4a8OwEmGJNmLKJ1pc7buCDoFw27urIQYtj5yHrYj3Elq_PLU7tkv_PKH8Bt5mqpQ</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Saad, Wilson Abrão</creator><creator>Motta Siqueira Guarda, Ismael Francisco</creator><creator>Saad Guarda, Renata</creator><creator>de Arruda Camargo, Luis Antonio</creator><creator>Brisola dos Santos, Talmir Augusto Faria</creator><creator>Saad, William Abrão</creator><creator>Simões, Sylvio</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Role of nitric oxide and β-adrenoceptors of the central nervous system on the salivary flow induced by pilocarpine injection into the lateral ventricle</title><author>Saad, Wilson Abrão ; Motta Siqueira Guarda, Ismael Francisco ; Saad Guarda, Renata ; de Arruda Camargo, Luis Antonio ; Brisola dos Santos, Talmir Augusto Faria ; Saad, William Abrão ; Simões, Sylvio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-59e8b28dd367376973398bd685c925b762b69530bdd01e6f4394035154b146d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System - drug effects</topic><topic>Central Nervous System - physiology</topic><topic>CNS</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraventricular</topic><topic>Lateral Ventricles - drug effects</topic><topic>Lateral Ventricles - metabolism</topic><topic>Male</topic><topic>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - physiology</topic><topic>Pilocarpine</topic><topic>Pilocarpine - administration & dosage</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Adrenergic, beta - physiology</topic><topic>Saliva - drug effects</topic><topic>Saliva - metabolism</topic><topic>Salivary secretion</topic><topic>Vertebrates: digestive system</topic><topic>β-adrenoceptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saad, Wilson Abrão</creatorcontrib><creatorcontrib>Motta Siqueira Guarda, Ismael Francisco</creatorcontrib><creatorcontrib>Saad Guarda, Renata</creatorcontrib><creatorcontrib>de Arruda Camargo, Luis Antonio</creatorcontrib><creatorcontrib>Brisola dos Santos, Talmir Augusto Faria</creatorcontrib><creatorcontrib>Saad, William Abrão</creatorcontrib><creatorcontrib>Simões, Sylvio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saad, Wilson Abrão</au><au>Motta Siqueira Guarda, Ismael Francisco</au><au>Saad Guarda, Renata</au><au>de Arruda Camargo, Luis Antonio</au><au>Brisola dos Santos, Talmir Augusto Faria</au><au>Saad, William Abrão</au><au>Simões, Sylvio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of nitric oxide and β-adrenoceptors of the central nervous system on the salivary flow induced by pilocarpine injection into the lateral ventricle</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>72</volume><issue>1</issue><spage>229</spage><epage>235</epage><pages>229-235</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Our studies have focused on the effect of
l-
NG-nitroarginine methyl ester (
l-NAME), an inhibitor of nitric oxide synthase (NOS), and
l-arginine, the substrate of NOS, on salivary secretion induced by the administration of pilocarpine into the lateral cerebral ventricle (LV) of rats. The present study has also investigated the role of the β-adrenergic agonists and antagonist injected into LV on the salivary secretion elicited by the injection of pilocarpine into LV. Male Holtzman rats with a stainless-steel cannula implanted into the LV were used. The amount of salivary secretion was studied over a 7-min period after injection of pilocarpine, isoproterenol, propranolol, salbutamol, salmeterol,
l-NAME and
l-arginine. The injection of pilocarpine (10, 20, 40, 80 and 160 μg/μl) into LV produced a dose-dependent increase in salivary secretion. The injection of
l-NAME (40 μg/μl) into LV alone produced an increase in salivary secretion. The injection of
l-NAME into LV previous to the injection of pilocarpine produced an increase in salivary secretion.
l-Arginine (30 μg/μl) injected alone into LV produced no change in salivary secretion.
l-Arginine injected into LV attenuated pilocarpine-induced salivary secretion. The isoproterenol (40 nmol/μl) injected into LV increased the salivary secretion. When injected previous to pilocarpine at a dose of 20 and 40 μg/μl, isoproterenol produced an additive effect on pilocarpine-induced salivary secretion. The 40-nmol/μl dose of propranolol injected alone or previous to pilocarpine into LV attenuated the pilocarpine-induced salivary secretion. The injection of salbutamol (40 nmol/μl), a specific β-2 agonist, injected alone into LV produced no change in salivary secretion and when injected previous to pilocarpine produced an increase in salivary secretion. The 40-nmol/μl dose of salmeterol, a long-acting β-2 agonist, injected into LV alone or previous to pilocarpine produced no change in salivary secretion. The results have shown that central injections of
l-NAME and
l-arginine interfere with the salivary secretion, which implies that might participate in pilocarpine-induced salivary secretion. The interaction between cholinergic and β-adrenergic receptors of the central nervous system (CNS) for the control of salivary secretion can also be postulated.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11900793</pmid><doi>10.1016/S0091-3057(01)00760-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 2002-05, Vol.72 (1), p.229-235 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Central Nervous System - drug effects Central Nervous System - physiology CNS Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Injections, Intraventricular Lateral Ventricles - drug effects Lateral Ventricles - metabolism Male Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Nitric oxide Nitric Oxide - physiology Pilocarpine Pilocarpine - administration & dosage Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta - physiology Saliva - drug effects Saliva - metabolism Salivary secretion Vertebrates: digestive system β-adrenoceptors |
| title | Role of nitric oxide and β-adrenoceptors of the central nervous system on the salivary flow induced by pilocarpine injection into the lateral ventricle |
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