Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties?
Background: Administration of large amounts of fluids to trauma patients, in the absence of surgical control, may increase bleeding, cause hypothermia and coagulopathy which may worsen the bleeding and increase morbidity and mortality. The purpose of our study is to examine the impact of prehospital...
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| Veröffentlicht in: | Injury 2002-03, Vol.33 (2), p.103-110 |
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| creator | Farkash, Uri Lynn, Mauricio Scope, Alon Maor, Ron Turchin, Nickolai Sverdlik, Borris Eldad, Arieh |
| description | Background: Administration of large amounts of fluids to trauma patients, in the absence of surgical control, may increase bleeding, cause hypothermia and coagulopathy which may worsen the bleeding and increase morbidity and mortality. The purpose of our study is to examine the impact of prehospital fluid administration to military combat casualties on core body temperature and coagulation functions.
Methods: Prospective data were collected on all cases of moderately (9≤ISS≤14) and severely (ISS≥16) injured victims wounded in South Lebanon, treated by Israeli military physicians and evacuated to hospitals in Israel, over a two-year period. Data regarding prehospital phase of injury (timetables, amount of fluids) and upon hospital arrival (initial core body temperature, prothrombin time [PT], partial thromboplastin time [PTT]) were examined for monotonic relation using Spearman's non-parametric test.
Results: Fifty-three moderately injured and 31 severely injured patients were included in the study. The average evacuation time for the moderately injured group was 109.3±44.8 min, and for the severely injured 100.3±38.4 min (
P value=NS). The mean volume of fluids administered was 2.39±1.52 and 2.49±1.47 l, respectively (
P=NS). No statistical correlation was found between core body temperature, PT or PTT, measured upon hospital arrival, and prehospital fluid treatment. In addition, no correlation was found between core body temperature on hospital arrival and prehospital time, or between prehospital fluid volumes and prehospital time. The mean core body temperature of the moderately injured patients was 36.8
°C, and that of severely injured was 35.8
°C (
P=0.026).
Conclusions: With proper control of blood loss and avoidance of excessive fluid administration, moderately and severely injured combat casualties in ‘low intensity conflict’ in South Lebanon can be resuscitated with fluid volumes that do not result in a coagulation deficit or hypothermia. The core body temperature on arrival at the hospital is related to the severity of the injury. |
| doi_str_mv | 10.1016/S0020-1383(01)00149-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71525653</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0020138301001498</els_id><sourcerecordid>71525653</sourcerecordid><originalsourceid>FETCH-LOGICAL-c486t-79d48ec852f764ad2343654bd3d822c8a324bce7d472e6320ac37279e1b4cb8c3</originalsourceid><addsrcrecordid>eNqFkMtu1TAURS0EoreFTwBlAiqDFL9iO6MKtTwqVWIAjK0T-wSMkjjYDlL_vr69V3TIyEfeax9bi5BXjF4wytT7b5Ry2jJhxDll7yhlsm_NE7JjRvct5Uo_Jbt_yAk5zfl3hTQV4jk5Ycz0tGd0R9J1xNysCX_FvIYCUzNOW_AN-DksIZcEJcSlCfMKrjQuJmyG6O-agvOKNdzqBSy-JvBzmw7wuC1uP-QmLDWYB6hNyBtMJWC-fEGejTBlfHk8z8iPTx-_X31pb79-vrn6cNs6aVRpde-lQWc6PmolwXMhherk4IU3nDsDgsvBofZSc1SCU3BCc90jG6QbjBNn5O1h75rinw1zsXPIDqcJFoxbtpp1vFOdqGB3AF2KOScc7ZrCDOnOMmr3su2DbLs3aSmzD7Ktqb3Xxwe2YUb_2DrarcCbIwDZwTQmWFzIj5zoVG96VbnLA4dVx9-AyWYXcHHoQ0JXrI_hP1-5BzcdnYw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71525653</pqid></control><display><type>article</type><title>Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Farkash, Uri ; Lynn, Mauricio ; Scope, Alon ; Maor, Ron ; Turchin, Nickolai ; Sverdlik, Borris ; Eldad, Arieh</creator><creatorcontrib>Farkash, Uri ; Lynn, Mauricio ; Scope, Alon ; Maor, Ron ; Turchin, Nickolai ; Sverdlik, Borris ; Eldad, Arieh</creatorcontrib><description>Background: Administration of large amounts of fluids to trauma patients, in the absence of surgical control, may increase bleeding, cause hypothermia and coagulopathy which may worsen the bleeding and increase morbidity and mortality. The purpose of our study is to examine the impact of prehospital fluid administration to military combat casualties on core body temperature and coagulation functions.
Methods: Prospective data were collected on all cases of moderately (9≤ISS≤14) and severely (ISS≥16) injured victims wounded in South Lebanon, treated by Israeli military physicians and evacuated to hospitals in Israel, over a two-year period. Data regarding prehospital phase of injury (timetables, amount of fluids) and upon hospital arrival (initial core body temperature, prothrombin time [PT], partial thromboplastin time [PTT]) were examined for monotonic relation using Spearman's non-parametric test.
Results: Fifty-three moderately injured and 31 severely injured patients were included in the study. The average evacuation time for the moderately injured group was 109.3±44.8 min, and for the severely injured 100.3±38.4 min (
P value=NS). The mean volume of fluids administered was 2.39±1.52 and 2.49±1.47 l, respectively (
P=NS). No statistical correlation was found between core body temperature, PT or PTT, measured upon hospital arrival, and prehospital fluid treatment. In addition, no correlation was found between core body temperature on hospital arrival and prehospital time, or between prehospital fluid volumes and prehospital time. The mean core body temperature of the moderately injured patients was 36.8
°C, and that of severely injured was 35.8
°C (
P=0.026).
Conclusions: With proper control of blood loss and avoidance of excessive fluid administration, moderately and severely injured combat casualties in ‘low intensity conflict’ in South Lebanon can be resuscitated with fluid volumes that do not result in a coagulation deficit or hypothermia. The core body temperature on arrival at the hospital is related to the severity of the injury.</description><identifier>ISSN: 0020-1383</identifier><identifier>EISSN: 1879-0267</identifier><identifier>DOI: 10.1016/S0020-1383(01)00149-8</identifier><identifier>PMID: 11890910</identifier><identifier>CODEN: INJUBF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Coagulation ; Body Temperature ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Emergency Medical Services - methods ; Fluid Therapy ; Humans ; Injury Severity Score ; Intensive care medicine ; Israel ; Medical sciences ; Military Personnel ; Partial Thromboplastin Time ; Prospective Studies ; Prothrombin Time ; Tropical medicine ; Warfare ; Wounds and Injuries - blood ; Wounds and Injuries - physiopathology ; Wounds and Injuries - therapy</subject><ispartof>Injury, 2002-03, Vol.33 (2), p.103-110</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-79d48ec852f764ad2343654bd3d822c8a324bce7d472e6320ac37279e1b4cb8c3</citedby><cites>FETCH-LOGICAL-c486t-79d48ec852f764ad2343654bd3d822c8a324bce7d472e6320ac37279e1b4cb8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0020-1383(01)00149-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13569896$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11890910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farkash, Uri</creatorcontrib><creatorcontrib>Lynn, Mauricio</creatorcontrib><creatorcontrib>Scope, Alon</creatorcontrib><creatorcontrib>Maor, Ron</creatorcontrib><creatorcontrib>Turchin, Nickolai</creatorcontrib><creatorcontrib>Sverdlik, Borris</creatorcontrib><creatorcontrib>Eldad, Arieh</creatorcontrib><title>Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties?</title><title>Injury</title><addtitle>Injury</addtitle><description>Background: Administration of large amounts of fluids to trauma patients, in the absence of surgical control, may increase bleeding, cause hypothermia and coagulopathy which may worsen the bleeding and increase morbidity and mortality. The purpose of our study is to examine the impact of prehospital fluid administration to military combat casualties on core body temperature and coagulation functions.
Methods: Prospective data were collected on all cases of moderately (9≤ISS≤14) and severely (ISS≥16) injured victims wounded in South Lebanon, treated by Israeli military physicians and evacuated to hospitals in Israel, over a two-year period. Data regarding prehospital phase of injury (timetables, amount of fluids) and upon hospital arrival (initial core body temperature, prothrombin time [PT], partial thromboplastin time [PTT]) were examined for monotonic relation using Spearman's non-parametric test.
Results: Fifty-three moderately injured and 31 severely injured patients were included in the study. The average evacuation time for the moderately injured group was 109.3±44.8 min, and for the severely injured 100.3±38.4 min (
P value=NS). The mean volume of fluids administered was 2.39±1.52 and 2.49±1.47 l, respectively (
P=NS). No statistical correlation was found between core body temperature, PT or PTT, measured upon hospital arrival, and prehospital fluid treatment. In addition, no correlation was found between core body temperature on hospital arrival and prehospital time, or between prehospital fluid volumes and prehospital time. The mean core body temperature of the moderately injured patients was 36.8
°C, and that of severely injured was 35.8
°C (
P=0.026).
Conclusions: With proper control of blood loss and avoidance of excessive fluid administration, moderately and severely injured combat casualties in ‘low intensity conflict’ in South Lebanon can be resuscitated with fluid volumes that do not result in a coagulation deficit or hypothermia. The core body temperature on arrival at the hospital is related to the severity of the injury.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation</subject><subject>Body Temperature</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Emergency Medical Services - methods</subject><subject>Fluid Therapy</subject><subject>Humans</subject><subject>Injury Severity Score</subject><subject>Intensive care medicine</subject><subject>Israel</subject><subject>Medical sciences</subject><subject>Military Personnel</subject><subject>Partial Thromboplastin Time</subject><subject>Prospective Studies</subject><subject>Prothrombin Time</subject><subject>Tropical medicine</subject><subject>Warfare</subject><subject>Wounds and Injuries - blood</subject><subject>Wounds and Injuries - physiopathology</subject><subject>Wounds and Injuries - therapy</subject><issn>0020-1383</issn><issn>1879-0267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu1TAURS0EoreFTwBlAiqDFL9iO6MKtTwqVWIAjK0T-wSMkjjYDlL_vr69V3TIyEfeax9bi5BXjF4wytT7b5Ry2jJhxDll7yhlsm_NE7JjRvct5Uo_Jbt_yAk5zfl3hTQV4jk5Ycz0tGd0R9J1xNysCX_FvIYCUzNOW_AN-DksIZcEJcSlCfMKrjQuJmyG6O-agvOKNdzqBSy-JvBzmw7wuC1uP-QmLDWYB6hNyBtMJWC-fEGejTBlfHk8z8iPTx-_X31pb79-vrn6cNs6aVRpde-lQWc6PmolwXMhherk4IU3nDsDgsvBofZSc1SCU3BCc90jG6QbjBNn5O1h75rinw1zsXPIDqcJFoxbtpp1vFOdqGB3AF2KOScc7ZrCDOnOMmr3su2DbLs3aSmzD7Ktqb3Xxwe2YUb_2DrarcCbIwDZwTQmWFzIj5zoVG96VbnLA4dVx9-AyWYXcHHoQ0JXrI_hP1-5BzcdnYw</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Farkash, Uri</creator><creator>Lynn, Mauricio</creator><creator>Scope, Alon</creator><creator>Maor, Ron</creator><creator>Turchin, Nickolai</creator><creator>Sverdlik, Borris</creator><creator>Eldad, Arieh</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties?</title><author>Farkash, Uri ; Lynn, Mauricio ; Scope, Alon ; Maor, Ron ; Turchin, Nickolai ; Sverdlik, Borris ; Eldad, Arieh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-79d48ec852f764ad2343654bd3d822c8a324bce7d472e6320ac37279e1b4cb8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation</topic><topic>Body Temperature</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Emergency Medical Services - methods</topic><topic>Fluid Therapy</topic><topic>Humans</topic><topic>Injury Severity Score</topic><topic>Intensive care medicine</topic><topic>Israel</topic><topic>Medical sciences</topic><topic>Military Personnel</topic><topic>Partial Thromboplastin Time</topic><topic>Prospective Studies</topic><topic>Prothrombin Time</topic><topic>Tropical medicine</topic><topic>Warfare</topic><topic>Wounds and Injuries - blood</topic><topic>Wounds and Injuries - physiopathology</topic><topic>Wounds and Injuries - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farkash, Uri</creatorcontrib><creatorcontrib>Lynn, Mauricio</creatorcontrib><creatorcontrib>Scope, Alon</creatorcontrib><creatorcontrib>Maor, Ron</creatorcontrib><creatorcontrib>Turchin, Nickolai</creatorcontrib><creatorcontrib>Sverdlik, Borris</creatorcontrib><creatorcontrib>Eldad, Arieh</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Injury</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farkash, Uri</au><au>Lynn, Mauricio</au><au>Scope, Alon</au><au>Maor, Ron</au><au>Turchin, Nickolai</au><au>Sverdlik, Borris</au><au>Eldad, Arieh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties?</atitle><jtitle>Injury</jtitle><addtitle>Injury</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>33</volume><issue>2</issue><spage>103</spage><epage>110</epage><pages>103-110</pages><issn>0020-1383</issn><eissn>1879-0267</eissn><coden>INJUBF</coden><abstract>Background: Administration of large amounts of fluids to trauma patients, in the absence of surgical control, may increase bleeding, cause hypothermia and coagulopathy which may worsen the bleeding and increase morbidity and mortality. The purpose of our study is to examine the impact of prehospital fluid administration to military combat casualties on core body temperature and coagulation functions.
Methods: Prospective data were collected on all cases of moderately (9≤ISS≤14) and severely (ISS≥16) injured victims wounded in South Lebanon, treated by Israeli military physicians and evacuated to hospitals in Israel, over a two-year period. Data regarding prehospital phase of injury (timetables, amount of fluids) and upon hospital arrival (initial core body temperature, prothrombin time [PT], partial thromboplastin time [PTT]) were examined for monotonic relation using Spearman's non-parametric test.
Results: Fifty-three moderately injured and 31 severely injured patients were included in the study. The average evacuation time for the moderately injured group was 109.3±44.8 min, and for the severely injured 100.3±38.4 min (
P value=NS). The mean volume of fluids administered was 2.39±1.52 and 2.49±1.47 l, respectively (
P=NS). No statistical correlation was found between core body temperature, PT or PTT, measured upon hospital arrival, and prehospital fluid treatment. In addition, no correlation was found between core body temperature on hospital arrival and prehospital time, or between prehospital fluid volumes and prehospital time. The mean core body temperature of the moderately injured patients was 36.8
°C, and that of severely injured was 35.8
°C (
P=0.026).
Conclusions: With proper control of blood loss and avoidance of excessive fluid administration, moderately and severely injured combat casualties in ‘low intensity conflict’ in South Lebanon can be resuscitated with fluid volumes that do not result in a coagulation deficit or hypothermia. The core body temperature on arrival at the hospital is related to the severity of the injury.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11890910</pmid><doi>10.1016/S0020-1383(01)00149-8</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation Body Temperature Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Emergency Medical Services - methods Fluid Therapy Humans Injury Severity Score Intensive care medicine Israel Medical sciences Military Personnel Partial Thromboplastin Time Prospective Studies Prothrombin Time Tropical medicine Warfare Wounds and Injuries - blood Wounds and Injuries - physiopathology Wounds and Injuries - therapy |
| title | Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties? |
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