Influence of Backbone Conformation on Protein Aggregation

Effect(s) of organic solvents on an all β-sheet protein are investigated to understand the influence of backbone conformation on protein aggregation. Results obtained in the present study reveal that protein aggregation is accompanied by the formation of non-native β-sheet conformation. In contrast,...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-03, Vol.124 (9), p.1884-1888
Hauptverfasser:	Srisailam, Sampath, Kumar, Thallampuranam Krishnaswamy S, Srimathi, Thiagarajan, Yu, Chin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Circular Dichroism Fibroblast Growth Factor 1 - chemistry Fundamental and applied biological sciences. Psychology General aspects, investigation methods Protein Structure, Secondary Proteins Salamandridae Solvents - chemistry Trifluoroethanol - chemistry
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