Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus

Puumala (PUU) virus causes a form of hemorrhagic fever with renal syndrome (HFRS), called nephropathia epidemica (NE), in Europe. HFRS is characterized by an increased capillary permeability, which we hypothesize is caused by hyperactivation of the host immune system, especially cellular immune resp...

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Veröffentlicht in:	Virus research 2002-03, Vol.84 (1), p.67-77
Hauptverfasser:	Terajima, Masanori, Van Epps, Heather L, Li, Dexin, Leporati, Anita M, Juhlin, Sarah E, Mustonen, Jukka, Vaheri, Antti, Ennis, Francis A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cercopithecus aethiops COS Cells Cytotoxic T lymphocyte DNA, Viral Gene Expression Genetic Vectors - genetics Hemorrhagic Fever with Renal Syndrome - blood Hemorrhagic Fever with Renal Syndrome - immunology Humans Leukocytes, Mononuclear - immunology Molecular Sequence Data Nephropathia epidemica Nucleocapsid - genetics Nucleocapsid - immunology Nucleocapsid Proteins Puumala virus Puumala virus - genetics Puumala virus - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant vaccinia virus Recombination, Genetic T-Lymphocytes, Cytotoxic - immunology T7 expression system Vaccinia virus - genetics Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology
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