A new surgical approach for the treatment of severe epithelial skin sun-induced damage
ABSTRACT Background Cutaneous photoageing is a complex biological process affecting all layers of the skin. Skin damage resulting from intrinsic ageing and extrinsic photoageing may trigger skin cancer. In patients with advanced photoageing and/or diffuse actinic damage, local therapy is often inad...
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| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2003-11, Vol.17 (6), p.680-683 |
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| container_title | Journal of the European Academy of Dermatology and Venereology |
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| creator | Pianigiani, E Cherubini Di Simplicio, F Ierardi, F Taddeucci, P Andreassi, A Fimiani, M |
| description | ABSTRACT
Background Cutaneous photoageing is a complex biological process affecting all layers of the skin. Skin damage resulting from intrinsic ageing and extrinsic photoageing may trigger skin cancer. In patients with advanced photoageing and/or diffuse actinic damage, local therapy is often inadequate and the possibility of combined therapy needs to be assessed.
Subjects Here we report three cases of patients over 75 years of age with advanced diffuse epithelial skin damage of photoexposed areas consisting of several superficial actinic keratoses, ipermelanotic lesions and multiple skin cancers.
Methods Neoplastic lesions and damaged skin were removed by superficial erbium laser ablation and the epidermis reconstructed with autologous epidermal sheets expanded in vitro from healthy cells obtained from unexposed areas of the body.
Results Our initial studies show that this procedure is very effective in the short term for treating and preventing the UV‐induced skin cancer and precancerous lesions, and also suggest good long‐term control of the disease with very interesting aesthetic results. |
| doi_str_mv | 10.1046/j.1468-3083.2003.00835.x |
| format | Article |
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Background Cutaneous photoageing is a complex biological process affecting all layers of the skin. Skin damage resulting from intrinsic ageing and extrinsic photoageing may trigger skin cancer. In patients with advanced photoageing and/or diffuse actinic damage, local therapy is often inadequate and the possibility of combined therapy needs to be assessed.
Subjects Here we report three cases of patients over 75 years of age with advanced diffuse epithelial skin damage of photoexposed areas consisting of several superficial actinic keratoses, ipermelanotic lesions and multiple skin cancers.
Methods Neoplastic lesions and damaged skin were removed by superficial erbium laser ablation and the epidermis reconstructed with autologous epidermal sheets expanded in vitro from healthy cells obtained from unexposed areas of the body.
Results Our initial studies show that this procedure is very effective in the short term for treating and preventing the UV‐induced skin cancer and precancerous lesions, and also suggest good long‐term control of the disease with very interesting aesthetic results.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1046/j.1468-3083.2003.00835.x</identifier><identifier>PMID: 14761136</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; epidermal cultures ; Epithelium - pathology ; Epithelium - radiation effects ; Female ; Follow-Up Studies ; Humans ; laser resurfacing ; Laser Therapy - methods ; Male ; photoageing ; Risk Assessment ; Sampling Studies ; Severity of Illness Index ; Skin Aging - pathology ; Skin Neoplasms - pathology ; Skin Neoplasms - prevention & control ; Skin Neoplasms - surgery ; Skin Transplantation - methods ; Sunlight - adverse effects ; tissue engineering ; Ultraviolet Rays - adverse effects</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2003-11, Vol.17 (6), p.680-683</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4025-bf27985559246b71c9cbe734ed0d17781ad9f0ba88da63bf84286bb3eb528cf63</citedby><cites>FETCH-LOGICAL-c4025-bf27985559246b71c9cbe734ed0d17781ad9f0ba88da63bf84286bb3eb528cf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1468-3083.2003.00835.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1468-3083.2003.00835.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14761136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pianigiani, E</creatorcontrib><creatorcontrib>Cherubini Di Simplicio, F</creatorcontrib><creatorcontrib>Ierardi, F</creatorcontrib><creatorcontrib>Taddeucci, P</creatorcontrib><creatorcontrib>Andreassi, A</creatorcontrib><creatorcontrib>Fimiani, M</creatorcontrib><title>A new surgical approach for the treatment of severe epithelial skin sun-induced damage</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>ABSTRACT
Background Cutaneous photoageing is a complex biological process affecting all layers of the skin. Skin damage resulting from intrinsic ageing and extrinsic photoageing may trigger skin cancer. In patients with advanced photoageing and/or diffuse actinic damage, local therapy is often inadequate and the possibility of combined therapy needs to be assessed.
Subjects Here we report three cases of patients over 75 years of age with advanced diffuse epithelial skin damage of photoexposed areas consisting of several superficial actinic keratoses, ipermelanotic lesions and multiple skin cancers.
Methods Neoplastic lesions and damaged skin were removed by superficial erbium laser ablation and the epidermis reconstructed with autologous epidermal sheets expanded in vitro from healthy cells obtained from unexposed areas of the body.
Results Our initial studies show that this procedure is very effective in the short term for treating and preventing the UV‐induced skin cancer and precancerous lesions, and also suggest good long‐term control of the disease with very interesting aesthetic results.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Combined Modality Therapy</subject><subject>epidermal cultures</subject><subject>Epithelium - pathology</subject><subject>Epithelium - radiation effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>laser resurfacing</subject><subject>Laser Therapy - methods</subject><subject>Male</subject><subject>photoageing</subject><subject>Risk Assessment</subject><subject>Sampling Studies</subject><subject>Severity of Illness Index</subject><subject>Skin Aging - pathology</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Skin Neoplasms - surgery</subject><subject>Skin Transplantation - methods</subject><subject>Sunlight - adverse effects</subject><subject>tissue engineering</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyCfuCX4I_6IxKUq7UKpygUWxMWynUnrbT62dkK3_x5vd1WuPc1I8z4zowchTElJSSU_rktaSV1wonnJCOElyZ0oty_Q4mnwEi1IzWRR16I-Qm9SWhNCKBX6NTqilZKUcrlAqxM8wD1Oc7wO3nbYbjZxtP4Gt2PE0w3gKYKdehgmPLY4wV-IgGET8qgLOZ9uw5DpoQhDM3tocGN7ew1v0avWdgneHeox-nl-9uP0S3H5ffn19OSy8BVhonAtU7UWQtSskk5RX3sHilfQkIYqpalt6pY4q3VjJXetrpiWznFwgmnfSn6MPuz35q_vZkiT6UPy0HV2gHFORlHBKs1JDup90McxpQit2cTQ2_hgKDE7p2ZtdurMTp3ZOTWPTs02o-8PN2bXQ_MfPEjMgU_7wH3o4OHZi83F51VuMl7s8ZAm2D7hNt4aqbgS5tfV0og_YvltxX8bxv8BEAGUdg</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Pianigiani, E</creator><creator>Cherubini Di Simplicio, F</creator><creator>Ierardi, F</creator><creator>Taddeucci, P</creator><creator>Andreassi, A</creator><creator>Fimiani, M</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200311</creationdate><title>A new surgical approach for the treatment of severe epithelial skin sun-induced damage</title><author>Pianigiani, E ; Cherubini Di Simplicio, F ; Ierardi, F ; Taddeucci, P ; Andreassi, A ; Fimiani, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4025-bf27985559246b71c9cbe734ed0d17781ad9f0ba88da63bf84286bb3eb528cf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Combined Modality Therapy</topic><topic>epidermal cultures</topic><topic>Epithelium - pathology</topic><topic>Epithelium - radiation effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>laser resurfacing</topic><topic>Laser Therapy - methods</topic><topic>Male</topic><topic>photoageing</topic><topic>Risk Assessment</topic><topic>Sampling Studies</topic><topic>Severity of Illness Index</topic><topic>Skin Aging - pathology</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Skin Neoplasms - surgery</topic><topic>Skin Transplantation - methods</topic><topic>Sunlight - adverse effects</topic><topic>tissue engineering</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pianigiani, E</creatorcontrib><creatorcontrib>Cherubini Di Simplicio, F</creatorcontrib><creatorcontrib>Ierardi, F</creatorcontrib><creatorcontrib>Taddeucci, P</creatorcontrib><creatorcontrib>Andreassi, A</creatorcontrib><creatorcontrib>Fimiani, M</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pianigiani, E</au><au>Cherubini Di Simplicio, F</au><au>Ierardi, F</au><au>Taddeucci, P</au><au>Andreassi, A</au><au>Fimiani, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new surgical approach for the treatment of severe epithelial skin sun-induced damage</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2003-11</date><risdate>2003</risdate><volume>17</volume><issue>6</issue><spage>680</spage><epage>683</epage><pages>680-683</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>ABSTRACT
Background Cutaneous photoageing is a complex biological process affecting all layers of the skin. Skin damage resulting from intrinsic ageing and extrinsic photoageing may trigger skin cancer. In patients with advanced photoageing and/or diffuse actinic damage, local therapy is often inadequate and the possibility of combined therapy needs to be assessed.
Subjects Here we report three cases of patients over 75 years of age with advanced diffuse epithelial skin damage of photoexposed areas consisting of several superficial actinic keratoses, ipermelanotic lesions and multiple skin cancers.
Methods Neoplastic lesions and damaged skin were removed by superficial erbium laser ablation and the epidermis reconstructed with autologous epidermal sheets expanded in vitro from healthy cells obtained from unexposed areas of the body.
Results Our initial studies show that this procedure is very effective in the short term for treating and preventing the UV‐induced skin cancer and precancerous lesions, and also suggest good long‐term control of the disease with very interesting aesthetic results.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14761136</pmid><doi>10.1046/j.1468-3083.2003.00835.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Combined Modality Therapy epidermal cultures Epithelium - pathology Epithelium - radiation effects Female Follow-Up Studies Humans laser resurfacing Laser Therapy - methods Male photoageing Risk Assessment Sampling Studies Severity of Illness Index Skin Aging - pathology Skin Neoplasms - pathology Skin Neoplasms - prevention & control Skin Neoplasms - surgery Skin Transplantation - methods Sunlight - adverse effects tissue engineering Ultraviolet Rays - adverse effects |
| title | A new surgical approach for the treatment of severe epithelial skin sun-induced damage |
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