Deciphering components of impaired working memory in multiple sclerosis
To identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS). Although individuals with MS have consistently demonstrated WM impairments, the specific components involved (i.e., central executive versus...
Gespeichert in:
| Veröffentlicht in: | Cognitive and behavioral neurology 2003-03, Vol.16 (1), p.28-39 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 39 |
|---|---|
| container_issue | 1 |
| container_start_page | 28 |
| container_title | Cognitive and behavioral neurology |
| container_volume | 16 |
| creator | LENGENFELDER, Jean CHIARAVALLOTI, Nancy D RICKER, Joseph H DELUCA, John |
| description | To identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS).
Although individuals with MS have consistently demonstrated WM impairments, the specific components involved (i.e., central executive versus storage/maintenance) remain unclear.
Individuals with MS with and without cognitive impairment and healthy controls were administered a task primarily assessing storage and rehearsal/maintenance (auditory n-back) and a task with a significant central executive component (Paced Auditory Serial Addition Task).
Results indicate when the phonological loop is minimally challenged, maintenance of information is generally efficient. However, the addition of a central executive component to processing appears to be the key factor in differentiating individuals with MS with cognitive impairment from those without cognitive impairment and healthy controls.
Results indicated that the primary WM impairment in MS is within the central executive rather than the phonological loop. |
| doi_str_mv | 10.1097/00146965-200303000-00004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71524320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71524320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-7ac427c6273dd7c1add33996a1e4396c4ee4541a13349530d2ed15d59b929ebe3</originalsourceid><addsrcrecordid>eNqFkEtPwzAMgCMEYmPwF1AvcCs4r2Y5ogEDaRIXOFdZ4kKgL5JWaP-ejpXHDVmWLflzIn-EJBQuKGh1CUBFpjOZMgA-BEA6JIg9MqVS8JRngu7_9JxPyFGMrwAM6Hx-SCZUqExoradkeY3Wty8YfP2c2KZqmxrrLiZNkfiqNT6gSz6a8LYdV1g1YZP4Oqn6svNtiUm0JYYm-nhMDgpTRjwZ64w83d48Lu7S1cPyfnG1Si1XrEuVsYIpmzHFnVOWGuc41zozFAXXmRWIQgpqKOdCSw6OoaPSSb3WTOMa-Yyc795tQ_PeY-zyykeLZWlqbPqYKyqZ4Az-BRlIMRijAzjfgXY4JAYs8jb4yoRNTiHf2s6_bec_tvMv28Pq6fhHv67Q_S6OegfgbARMtKYsgqmtj385kFrN-SdtPocs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20540041</pqid></control><display><type>article</type><title>Deciphering components of impaired working memory in multiple sclerosis</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>LENGENFELDER, Jean ; CHIARAVALLOTI, Nancy D ; RICKER, Joseph H ; DELUCA, John</creator><creatorcontrib>LENGENFELDER, Jean ; CHIARAVALLOTI, Nancy D ; RICKER, Joseph H ; DELUCA, John</creatorcontrib><description>To identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS).
Although individuals with MS have consistently demonstrated WM impairments, the specific components involved (i.e., central executive versus storage/maintenance) remain unclear.
Individuals with MS with and without cognitive impairment and healthy controls were administered a task primarily assessing storage and rehearsal/maintenance (auditory n-back) and a task with a significant central executive component (Paced Auditory Serial Addition Task).
Results indicate when the phonological loop is minimally challenged, maintenance of information is generally efficient. However, the addition of a central executive component to processing appears to be the key factor in differentiating individuals with MS with cognitive impairment from those without cognitive impairment and healthy controls.
Results indicated that the primary WM impairment in MS is within the central executive rather than the phonological loop.</description><identifier>ISSN: 1543-3633</identifier><identifier>EISSN: 1543-3641</identifier><identifier>DOI: 10.1097/00146965-200303000-00004</identifier><identifier>PMID: 14764999</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Willkins</publisher><subject>Acoustic Stimulation ; Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Biological and medical sciences ; Cognition Disorders - complications ; Cognition Disorders - psychology ; Female ; Humans ; Male ; Medical sciences ; Memory Disorders - complications ; Memory Disorders - diagnosis ; Memory Disorders - psychology ; Mental Processes - physiology ; Middle Aged ; Multiple Sclerosis - complications ; Multiple Sclerosis - psychology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Neuropsychological Tests ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reference Values ; Verbal Learning - physiology</subject><ispartof>Cognitive and behavioral neurology, 2003-03, Vol.16 (1), p.28-39</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-7ac427c6273dd7c1add33996a1e4396c4ee4541a13349530d2ed15d59b929ebe3</citedby><cites>FETCH-LOGICAL-c372t-7ac427c6273dd7c1add33996a1e4396c4ee4541a13349530d2ed15d59b929ebe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14705978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14764999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LENGENFELDER, Jean</creatorcontrib><creatorcontrib>CHIARAVALLOTI, Nancy D</creatorcontrib><creatorcontrib>RICKER, Joseph H</creatorcontrib><creatorcontrib>DELUCA, John</creatorcontrib><title>Deciphering components of impaired working memory in multiple sclerosis</title><title>Cognitive and behavioral neurology</title><addtitle>Cogn Behav Neurol</addtitle><description>To identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS).
Although individuals with MS have consistently demonstrated WM impairments, the specific components involved (i.e., central executive versus storage/maintenance) remain unclear.
Individuals with MS with and without cognitive impairment and healthy controls were administered a task primarily assessing storage and rehearsal/maintenance (auditory n-back) and a task with a significant central executive component (Paced Auditory Serial Addition Task).
Results indicate when the phonological loop is minimally challenged, maintenance of information is generally efficient. However, the addition of a central executive component to processing appears to be the key factor in differentiating individuals with MS with cognitive impairment from those without cognitive impairment and healthy controls.
Results indicated that the primary WM impairment in MS is within the central executive rather than the phonological loop.</description><subject>Acoustic Stimulation</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - complications</subject><subject>Cognition Disorders - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - complications</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - psychology</subject><subject>Mental Processes - physiology</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - psychology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reference Values</subject><subject>Verbal Learning - physiology</subject><issn>1543-3633</issn><issn>1543-3641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAMgCMEYmPwF1AvcCs4r2Y5ogEDaRIXOFdZ4kKgL5JWaP-ejpXHDVmWLflzIn-EJBQuKGh1CUBFpjOZMgA-BEA6JIg9MqVS8JRngu7_9JxPyFGMrwAM6Hx-SCZUqExoradkeY3Wty8YfP2c2KZqmxrrLiZNkfiqNT6gSz6a8LYdV1g1YZP4Oqn6svNtiUm0JYYm-nhMDgpTRjwZ64w83d48Lu7S1cPyfnG1Si1XrEuVsYIpmzHFnVOWGuc41zozFAXXmRWIQgpqKOdCSw6OoaPSSb3WTOMa-Yyc795tQ_PeY-zyykeLZWlqbPqYKyqZ4Az-BRlIMRijAzjfgXY4JAYs8jb4yoRNTiHf2s6_bec_tvMv28Pq6fhHv67Q_S6OegfgbARMtKYsgqmtj385kFrN-SdtPocs</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>LENGENFELDER, Jean</creator><creator>CHIARAVALLOTI, Nancy D</creator><creator>RICKER, Joseph H</creator><creator>DELUCA, John</creator><general>Lippincott Williams & Willkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Deciphering components of impaired working memory in multiple sclerosis</title><author>LENGENFELDER, Jean ; CHIARAVALLOTI, Nancy D ; RICKER, Joseph H ; DELUCA, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-7ac427c6273dd7c1add33996a1e4396c4ee4541a13349530d2ed15d59b929ebe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acoustic Stimulation</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - complications</topic><topic>Cognition Disorders - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - complications</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - psychology</topic><topic>Mental Processes - physiology</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - psychology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reference Values</topic><topic>Verbal Learning - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LENGENFELDER, Jean</creatorcontrib><creatorcontrib>CHIARAVALLOTI, Nancy D</creatorcontrib><creatorcontrib>RICKER, Joseph H</creatorcontrib><creatorcontrib>DELUCA, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cognitive and behavioral neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LENGENFELDER, Jean</au><au>CHIARAVALLOTI, Nancy D</au><au>RICKER, Joseph H</au><au>DELUCA, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deciphering components of impaired working memory in multiple sclerosis</atitle><jtitle>Cognitive and behavioral neurology</jtitle><addtitle>Cogn Behav Neurol</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>16</volume><issue>1</issue><spage>28</spage><epage>39</epage><pages>28-39</pages><issn>1543-3633</issn><eissn>1543-3641</eissn><abstract>To identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS).
Although individuals with MS have consistently demonstrated WM impairments, the specific components involved (i.e., central executive versus storage/maintenance) remain unclear.
Individuals with MS with and without cognitive impairment and healthy controls were administered a task primarily assessing storage and rehearsal/maintenance (auditory n-back) and a task with a significant central executive component (Paced Auditory Serial Addition Task).
Results indicate when the phonological loop is minimally challenged, maintenance of information is generally efficient. However, the addition of a central executive component to processing appears to be the key factor in differentiating individuals with MS with cognitive impairment from those without cognitive impairment and healthy controls.
Results indicated that the primary WM impairment in MS is within the central executive rather than the phonological loop.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Willkins</pub><pmid>14764999</pmid><doi>10.1097/00146965-200303000-00004</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1543-3633 |
| ispartof | Cognitive and behavioral neurology, 2003-03, Vol.16 (1), p.28-39 |
| issn | 1543-3633 1543-3641 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71524320 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acoustic Stimulation Adult Adult and adolescent clinical studies Analysis of Variance Biological and medical sciences Cognition Disorders - complications Cognition Disorders - psychology Female Humans Male Medical sciences Memory Disorders - complications Memory Disorders - diagnosis Memory Disorders - psychology Mental Processes - physiology Middle Aged Multiple Sclerosis - complications Multiple Sclerosis - psychology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuropsychological Tests Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reference Values Verbal Learning - physiology |
| title | Deciphering components of impaired working memory in multiple sclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T11%3A27%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deciphering%20components%20of%20impaired%20working%20memory%20in%20multiple%20sclerosis&rft.jtitle=Cognitive%20and%20behavioral%20neurology&rft.au=LENGENFELDER,%20Jean&rft.date=2003-03-01&rft.volume=16&rft.issue=1&rft.spage=28&rft.epage=39&rft.pages=28-39&rft.issn=1543-3633&rft.eissn=1543-3641&rft_id=info:doi/10.1097/00146965-200303000-00004&rft_dat=%3Cproquest_cross%3E71524320%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20540041&rft_id=info:pmid/14764999&rfr_iscdi=true |