Paraoxonase-1 L55M Polymorphism Is Associated with an Abnormal Oral Glucose Tolerance Test and Differentiates High Risk Coronary Disease Families

Polymorphisms of the gene for the antioxidant enzyme, paraoxonase-1 (PON1), have been identified as risk factors for coronary disease (CHD), notably in diabetic patients. The polymorphisms have also been linked with other diabetic complications. The present study analyzed glucose metabolism as a fun...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2002-03, Vol.87 (3), p.1268-1273
Hauptverfasser:	Deakin, Sara, Leviev, Ilia, Nicaud, Viviane, Meynet, Marie-Claude Brulhart, Tiret, Laurence, James, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aryldialkylphosphatase Biological and medical sciences Coronary Disease - genetics Endocrinopathies Esterases - genetics Fasting - blood Functional investigation of endocrine glands and genital system Gene Frequency Genetic Predisposition to Disease - genetics Glucose Tolerance Test Humans Insulin - metabolism Insulin Resistance Insulin Secretion Investigative techniques, diagnostic techniques (general aspects) Lipids - blood Lipoproteins - blood Male Malignant tumors Medical sciences Polymorphism, Genetic - physiology Risk Factors Thyroid. Thyroid axis (diseases)
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