Nuclear magnetic resonance-visible lipids induced by cationic lipophilic chemotherapeutic agents are accompanied by increased lipid droplet formation and damaged mitochondria

Proton nuclear magnetic resonance (NMR) spectroscopy, histological lipid staining, and electron microscopy were used to assess the biochemical and structural changes induced by treating the cultured human breast cell line HBL-100 with the cationic lipophilic phosphonium salts p-(triphenylphosphonium...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-03, Vol.62 (5), p.1394-1400
Hauptverfasser:	Delikatny, Edward J, Cooper, Wendy A, Brammah, Susan, Sathasivam, Nalayini, Rideout, Darryl C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Breast - metabolism Breast - ultrastructure Cytoplasm - metabolism Female Humans Lipid Metabolism Lysosomes - metabolism Magnetic Resonance Spectroscopy Microscopy, Electron Mitochondria - ultrastructure Organophosphorus Compounds - pharmacology Tumor Cells, Cultured
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