Malaria is not responsible for the selection of TCR beta-subunit variable gene haplotypes in The Gambia

Previous work has shown that a single haplotype of the T-cell antigen receptor beta-subunit (TCRB) locus is predominant in African populations. This is likely to be due to selection pressure for gene(s) that protect children against disease. This study has tested the hypothesis that malaria is the r...

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Veröffentlicht in:	Immunogenetics (New York) 2002-02, Vol.53 (10-11), p.894-899
Hauptverfasser:	Donaldson, Ian J, Shefta, Jahan, Hill, Adrian V S, Boylston, Arthur W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult BV15S1 gene BV2S1 gene BV3S1 gene BV8S3 gene Child Complementarity Determining Regions - genetics Female Gambia - epidemiology Gene Frequency Genes, T-Cell Receptor beta - genetics Genetic Variation - genetics Haplotypes - genetics Humans Malaria - epidemiology Malaria - genetics Malaria - immunology Male Plasmodium Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Receptors, Antigen, T-Cell, alpha-beta - genetics Selection, Genetic
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