Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye
Planar polarity is evident in the coordinated orientation of ommatidia in the Drosophila eye. This process requires that the R3 photoreceptor precursor of each ommatidium have a higher level of Frizzled signaling than its neighboring R4 precursor. We show that two cadherin superfamily members, Fat a...
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| Veröffentlicht in: | Cell 2002-03, Vol.108 (5), p.675-688 |
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| creator | Yang, Chung-hui Axelrod, Jeffrey D. Simon, Michael A. |
| description | Planar polarity is evident in the coordinated orientation of ommatidia in the
Drosophila eye. This process requires that the R3 photoreceptor precursor of each ommatidium have a higher level of Frizzled signaling than its neighboring R4 precursor. We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process. Our data support a model in which the bias of Frizzled signaling between the R3/R4 precursors results from higher Fat function in the precursor cell closer to the equator, which becomes R3. We also provide evidence that positional information regulating Fat action is provided by graded expression of Dachsous across the eye and the action of Four-jointed, which is expressed in an opposing expression gradient and appears to modulate Dachsous function. |
| doi_str_mv | 10.1016/S0092-8674(02)00658-X |
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Drosophila eye. This process requires that the R3 photoreceptor precursor of each ommatidium have a higher level of Frizzled signaling than its neighboring R4 precursor. We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process. Our data support a model in which the bias of Frizzled signaling between the R3/R4 precursors results from higher Fat function in the precursor cell closer to the equator, which becomes R3. We also provide evidence that positional information regulating Fat action is provided by graded expression of Dachsous across the eye and the action of Four-jointed, which is expressed in an opposing expression gradient and appears to modulate Dachsous function.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(02)00658-X</identifier><identifier>PMID: 11893338</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cadherins - genetics ; Cadherins - metabolism ; Cell Polarity - physiology ; Drosophila ; Drosophila melanogaster - physiology ; Drosophila Proteins ; frizzled gene ; Frizzled Receptors ; Immunohistochemistry ; Insect Hormones - genetics ; Insect Hormones - metabolism ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - metabolism ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Models, Biological ; Photoreceptor Cells, Invertebrate - growth & development ; Photoreceptor Cells, Invertebrate - physiology ; Photoreceptor Cells, Invertebrate - ultrastructure ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Receptors, G-Protein-Coupled ; Signal Transduction - physiology ; Transcription, Genetic</subject><ispartof>Cell, 2002-03, Vol.108 (5), p.675-688</ispartof><rights>2002 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-cd04a5a1dd0c4bdc2798c0be2ebdaeeed904f13ba819f5a9c3bc8f2d562722283</citedby><cites>FETCH-LOGICAL-c557t-cd04a5a1dd0c4bdc2798c0be2ebdaeeed904f13ba819f5a9c3bc8f2d562722283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009286740200658X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11893338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Chung-hui</creatorcontrib><creatorcontrib>Axelrod, Jeffrey D.</creatorcontrib><creatorcontrib>Simon, Michael A.</creatorcontrib><title>Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye</title><title>Cell</title><addtitle>Cell</addtitle><description>Planar polarity is evident in the coordinated orientation of ommatidia in the
Drosophila eye. This process requires that the R3 photoreceptor precursor of each ommatidium have a higher level of Frizzled signaling than its neighboring R4 precursor. We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process. Our data support a model in which the bias of Frizzled signaling between the R3/R4 precursors results from higher Fat function in the precursor cell closer to the equator, which becomes R3. We also provide evidence that positional information regulating Fat action is provided by graded expression of Dachsous across the eye and the action of Four-jointed, which is expressed in an opposing expression gradient and appears to modulate Dachsous function.</description><subject>Animals</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>Cell Polarity - physiology</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins</subject><subject>frizzled gene</subject><subject>Frizzled Receptors</subject><subject>Immunohistochemistry</subject><subject>Insect Hormones - genetics</subject><subject>Insect Hormones - metabolism</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Models, Biological</subject><subject>Photoreceptor Cells, Invertebrate - growth & development</subject><subject>Photoreceptor Cells, Invertebrate - physiology</subject><subject>Photoreceptor Cells, Invertebrate - ultrastructure</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Signal Transduction - physiology</subject><subject>Transcription, Genetic</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFPGzEQha2qqATan1DkU1UOC2PvOus9VVWaFCQkogYkbpbXnk1MnXWwdyuFX98NieDI6R3mm3kz8wj5yuCCARtfLgAqnslxWXwHfg4wFjJ7-EBGDKoyK1jJP5LRK3JMTlJ6BAAphPhEjhmTVZ7nckT8H1z2XncutDQ0dBbd87NHS-stneku8-4v0om2K4yuTdT2gyzp3OtWRzoPXkfXbenCLVvtdxXX0m6F9FcMKWxWzms6CetN6FtLp1v8TI4a7RN-OegpuZ9N7yZX2c3t7-vJz5vMCFF2mbFQaKGZtWCK2hpeVtJAjRxrqxHRVlA0LK-1ZFUjdGXy2siGWzHmJedc5qfk237uJoanHlOn1i4Z9MPaGPqkSibYALN3QSZzqIoSBlDsQTNcliI2ahPdWsetYqB2eaiXPNTu2Qq4eslDPQx9ZweDvl6jfes6BDAAP_YADv_45zCqZBy2Bq2LaDplg3vH4j-47pxN</recordid><startdate>20020308</startdate><enddate>20020308</enddate><creator>Yang, Chung-hui</creator><creator>Axelrod, Jeffrey D.</creator><creator>Simon, Michael A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20020308</creationdate><title>Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye</title><author>Yang, Chung-hui ; Axelrod, Jeffrey D. ; Simon, Michael A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-cd04a5a1dd0c4bdc2798c0be2ebdaeeed904f13ba819f5a9c3bc8f2d562722283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>Cell Polarity - physiology</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila Proteins</topic><topic>frizzled gene</topic><topic>Frizzled Receptors</topic><topic>Immunohistochemistry</topic><topic>Insect Hormones - genetics</topic><topic>Insect Hormones - metabolism</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Models, Biological</topic><topic>Photoreceptor Cells, Invertebrate - growth & development</topic><topic>Photoreceptor Cells, Invertebrate - physiology</topic><topic>Photoreceptor Cells, Invertebrate - ultrastructure</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, G-Protein-Coupled</topic><topic>Signal Transduction - physiology</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Chung-hui</creatorcontrib><creatorcontrib>Axelrod, Jeffrey D.</creatorcontrib><creatorcontrib>Simon, Michael A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Chung-hui</au><au>Axelrod, Jeffrey D.</au><au>Simon, Michael A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2002-03-08</date><risdate>2002</risdate><volume>108</volume><issue>5</issue><spage>675</spage><epage>688</epage><pages>675-688</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Planar polarity is evident in the coordinated orientation of ommatidia in the
Drosophila eye. This process requires that the R3 photoreceptor precursor of each ommatidium have a higher level of Frizzled signaling than its neighboring R4 precursor. We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process. Our data support a model in which the bias of Frizzled signaling between the R3/R4 precursors results from higher Fat function in the precursor cell closer to the equator, which becomes R3. We also provide evidence that positional information regulating Fat action is provided by graded expression of Dachsous across the eye and the action of Four-jointed, which is expressed in an opposing expression gradient and appears to modulate Dachsous function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11893338</pmid><doi>10.1016/S0092-8674(02)00658-X</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cadherins - genetics Cadherins - metabolism Cell Polarity - physiology Drosophila Drosophila melanogaster - physiology Drosophila Proteins frizzled gene Frizzled Receptors Immunohistochemistry Insect Hormones - genetics Insect Hormones - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Models, Biological Photoreceptor Cells, Invertebrate - growth & development Photoreceptor Cells, Invertebrate - physiology Photoreceptor Cells, Invertebrate - ultrastructure Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Signal Transduction - physiology Transcription, Genetic |
| title | Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye |
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