Adaptor Protein Complexes as the Key Regulators of Protein Sorting in the Post-Golgi Network
Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a piv...
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| Veröffentlicht in: | Cell Structure and Function 2003, Vol.28(5), pp.419-429 |
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| container_title | Cell Structure and Function |
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| creator | Nakatsu, Fubito Ohno, Hiroshi |
| description | Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a pivotal role in the cargo selection by recognizing the sorting signals within the cytoplasmic tail of integral membrane proteins. Six distinct AP complexes have been identified. AP-2 mediates endocytosis from the plasma membrane, while AP-1, AP-3 and AP-4 play a role in the endosomal/lysosomal sorting pathways. Moreover, tissue-specific sorting events such as the basolateral sorting in polarized epithelial cells and the biogenesis of specialized organelles including melanosomes and synaptic vesicles are also regulated by members of AP complexes. The application of a variety of methodologies have gradually revealed the physiological role of AP complexes. |
| doi_str_mv | 10.1247/csf.28.419 |
| format | Article |
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Funct.</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>28</volume><issue>5</issue><spage>419</spage><epage>429</epage><pages>419-429</pages><issn>0386-7196</issn><eissn>1347-3700</eissn><abstract>Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a pivotal role in the cargo selection by recognizing the sorting signals within the cytoplasmic tail of integral membrane proteins. Six distinct AP complexes have been identified. AP-2 mediates endocytosis from the plasma membrane, while AP-1, AP-3 and AP-4 play a role in the endosomal/lysosomal sorting pathways. 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| ispartof | Cell Structure and Function, 2003, Vol.28(5), pp.419-429 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | adaptor protein complex Adaptor Protein Complex Subunits - metabolism Adaptor Proteins, Vesicular Transport - metabolism Animals clathrin Endocytosis - physiology Exocytosis - physiology Golgi Apparatus - metabolism Humans Macromolecular Substances Membrane Proteins - metabolism membrane traffic post-Golgi network Protein Transport sorting signals Transport Vesicles - metabolism vesicular transport |
| title | Adaptor Protein Complexes as the Key Regulators of Protein Sorting in the Post-Golgi Network |
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