Transforming growth factor-β and forskolin attenuate the adverse effects of long-term Schwann cell denervation on peripheral nerve regeneration in vivo

Transforming growth factor‐β (TGF‐β) plays a central role in the regulation of Schwann cell (SC) proliferation and differentiation and is essential for the neurotrophic effects of several neurotrophic factors (reviewed by Unsicker and Krieglstein, 2000; Unsicker and Strelau, 2000). However, its role...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Glia 2002-03, Vol.37 (3), p.206-218
Hauptverfasser:	Sulaiman, Olawale A.R., Gordon, Tessa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - metabolism Axons - ultrastructure Biological and medical sciences chronic denervation Colforsin - pharmacology Denervation - methods Development. Senescence. Regeneration. Transplantation Disease Models, Animal distal nerve stump Female Fundamental and applied biological sciences. Psychology Motor Neurons - cytology Motor Neurons - drug effects Motor Neurons - metabolism Nerve Regeneration - drug effects Nerve Regeneration - physiology Neurosurgical Procedures - methods Organ Culture Techniques - methods Peripheral Nerve Injuries Peripheral Nerves - drug effects Peripheral Nerves - surgery PNS injury and regeneration poor functional recovery Prostheses and Implants Rats Rats, Sprague-Dawley Recovery of Function - drug effects Recovery of Function - physiology retrograde labeling Schwann cells Schwann Cells - cytology Schwann Cells - drug effects Schwann Cells - metabolism Time Factors Tissue Transplantation - methods Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology transforming growth factor-β Treatment Outcome Vertebrates: nervous system and sense organs Wallerian Degeneration - drug therapy Wallerian Degeneration - pathology Wallerian Degeneration - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!