Modeling the Active Site of Cytochrome Oxidase: Synthesis and Characterization of a Cross-Linked Histidine−Phenol

A cross-linked histidine−phenol compound was synthesized as a chemical analogue of the active site of cytochrome c oxidase. The structure of the cross-linked compound (compound 1) was verified by IR, 1H and 13C NMR, mass spectrometry, and single-crystal X-ray analysis. Spectrophotometric titrations...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-02, Vol.124 (8), p.1750-1760
Hauptverfasser:	Cappuccio, Jenny A, Ayala, Idelisa, Elliott, Gregory I, Szundi, Istvan, Lewis, James, Konopelski, Joseph P, Barry, Bridgette A, Einarsdóttir, Ólöf
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Crystallography, X-Ray Dipeptides - chemistry Electron Spin Resonance Spectroscopy Electron Transport Complex IV - chemistry Electron Transport Complex IV - metabolism Fundamental and applied biological sciences. Psychology Histidine - chemistry Models, Chemical Molecular and cellular biology Phenols - chemical synthesis Phenols - chemistry Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Tyrosine - chemistry
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