Calcium triggers β-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3α (MIP-3α/CCL20) expression in monolayers of activated human keratinocytes

: The inducible epidermal β‐defensins and the chemokine macrophage inflammatory protein‐3α (MIP‐3α/CCL20) are important mediators involved in innate and adaptive immunity and in the recruitment of immune cells. The aim of our study was to determine whether calcium could trigger the induction of β‐d...

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Veröffentlicht in:	Experimental dermatology 2003-12, Vol.12 (6), p.755-760
Hauptverfasser:	Pernet, I., Reymermier, C., Guezennec, A., Branka, J. -E., Guesnet, J., Perrier, E., Dezutter-Dambuyant, C., Schmitt, D., Viac, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Defensins - metabolism Biological and medical sciences calcium Calcium - metabolism Cell Culture Techniques Cells, Cultured Chemokine CCL20 Chemokines, CC - metabolism cytokine Dermatology Dose-Response Relationship, Drug Epidermal Cells Humans Interferon-gamma - metabolism Isoleucine - pharmacology keratinocyte Keratinocytes - metabolism l-isoleucine Macrophage Inflammatory Proteins - metabolism Medical sciences MIP-3α/CCL20 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Skin - metabolism Time Factors Tumor Necrosis Factor-alpha - metabolism Up-Regulation β-defensin
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