Clinical and laboratory evaluation of the safety of a bioartificial liver assist device for potential transmission of porcine endogenous retrovirus

The potential risk of transmission of porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated. Because we were involved in a phase I/II clinical trial using a bioartificial liver support system (BLSS), we proceeded to evaluate the biosafety of this device. T...

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Veröffentlicht in:	Transplantation 2002-02, Vol.73 (3), p.420-429
Hauptverfasser:	KUDDUS, R, PATZER, J. F, LOPEZ, R, MAZARIEGOS, G. V, MEIGHEN, B, KRAMER, D. J, RAO, A. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bioreactors Cell Line DNA, Viral - analysis Endogenous Retroviruses - isolation & purification Hepatocytes - virology Humans Liver, Artificial - adverse effects Liver, biliary tract, pancreas, portal circulation, spleen Medical sciences RNA, Viral - analysis RNA-Directed DNA Polymerase - metabolism Safety Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Swine - virology Virion - isolation & purification
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