Regeneration of Intraoral Defects after Tumor Resection with a Bioengineered Human Dermal Replacement (Dermagraft)
The experiences of seven patients with squamous cell carcinomas of the oral cavity who underwent reconstruction with a bioengineered human dermal replacement (Dermagraft) are examined. The human dermal replacement consists of fibroblasts seeded onto a three-dimensional polymer scaffold to create a l...
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| Veröffentlicht in: | Plastic and reconstructive surgery (1963) 2002-03, Vol.109 (3), p.889-893 |
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| container_title | Plastic and reconstructive surgery (1963) |
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| creator | Gath, Hans Joachim Hell, Berthold Zarrinbal, Ramin Bier, Jürgen Raguse, Jan-Dirk |
| description | The experiences of seven patients with squamous cell carcinomas of the oral cavity who underwent reconstruction with a bioengineered human dermal replacement (Dermagraft) are examined. The human dermal replacement consists of fibroblasts seeded onto a three-dimensional polymer scaffold to create a living dermal structure. In this setting, the fibroblasts secrete a mixture of growth factors and matrix proteins in physiological concentration that is essential for wound healing and epithelization. The fibroblast tissue remains metabolically active after cryopreservation and can be used as an off-the-shelf tissue to cover medium-sized defects and avoid donor-site morbidity. In the first series of patients treated with this tissue, defect closure was achieved without functional problems, allowing optimal postoperative monitoring for tumor recurrence. (Plast. Reconstr. Surg. 109889, 2002.) |
| doi_str_mv | 10.1097/00006534-200203000-00009 |
| format | Article |
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| identifier | ISSN: 0032-1052 |
| ispartof | Plastic and reconstructive surgery (1963), 2002-03, Vol.109 (3), p.889-893 |
| issn | 0032-1052 1529-4242 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Carcinoma, Squamous Cell - surgery Female Humans Male Middle Aged Mouth Floor - physiology Mouth Neoplasms - surgery Regeneration Tissue Engineering |
| title | Regeneration of Intraoral Defects after Tumor Resection with a Bioengineered Human Dermal Replacement (Dermagraft) |
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