Targeting of Endothelin Receptors for Molecular Imaging of Atherosclerosis in Rabbits

We wanted to determine whether a previously described in vivo accumulation of a (99m)Tc-labeled endothelin derivative in atherosclerotic lesions is mediated by binding to endothelin receptors. Furthermore, the expression of endothelin receptors in atherosclerotic lesions of 2 different rabbit animal...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2002-03, Vol.43 (3), p.400-405
Hauptverfasser:	Meding, Jorg, Dinkelborg, Ludger M, Grieshaber, Manfred K, Semmler, Wolfhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Arteriosclerosis - diagnostic imaging Arteriosclerosis - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Endothelin-1 - metabolism Endothelin-2 - metabolism Female In Vitro Techniques Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Medical sciences Rabbits Radionuclide Imaging Radionuclide investigations Receptors, Endothelin - metabolism Technetium
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