Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines

Integrin-mediated cell adhesion cooperates with growth factor receptors in the control of cell proliferation, cell survival, and cell migration. One mechanism to explain these synergistic effects is the ability of integrins to induce phosphorylation of growth factor receptors, for instance the epide...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (11), p.9405-9414
Hauptverfasser:	Moro, Laura, Dolce, Laura, Cabodi, Sara, Bergatto, Elena, Erba, Elisabetta Boeri, Smeriglio, Monica, Turco, Emilia, Retta, Saverio Francesco, Giuffrida, Maria Gabriella, Venturino, Mascia, Godovac-Zimmermann, Jasminka, Conti, Amedeo, Schaefer, Erik, Beguinot, Laura, Tacchetti, Carlo, Gaggini, Paolo, Silengo, Lorenzo, Tarone, Guido, Defilippi, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion Cell Line Crk-Associated Substrate Protein CSK Tyrosine-Protein Kinase ErbB Receptors - analysis ErbB Receptors - chemistry ErbB Receptors - metabolism Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Humans Integrins - chemistry Integrins - physiology Phosphoproteins - physiology Phosphorylation Protein-Tyrosine Kinases - physiology Proteins Retinoblastoma-Like Protein p130 src-Family Kinases Tyrosine - metabolism
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