Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes
The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies. Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, o...
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| Veröffentlicht in: | Journal of perinatal medicine 2003-01, Vol.31 (6), p.475-483 |
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| creator | King, R. G. Osmond, D. T. D. Brennecke, S. P. Gude, N. M. |
| description | The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies. Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, or 24 mM while the fetal D-glucose was maintained at 3mM. Hay WW: Regulation of placental metabolism by glucose supply. Reprod Fertil Dev 7 (1995) 365 C-D-glucose and Combs CA,E Gunderson, JL Kitzmiller, LA Gavin, EK Main: Relationship of fetal macrosomia to maternal postprandial glucose control during pregnancy. Diabetes Care 15 (1992) 1251 H-L-glucose were infused into the maternal circulation. Radioactivity, D-glucose and L-lactate levels were measured in the fetal and maternal effluent perfusates. Glucose uptake from the maternal perfusate, and transfer to the fetal effluent were not significantly different between groups. Insulin-treated GDM group without macrosomia had reduced glucose utilization compared to the control group while the insulin-treated GDM group with macrosomia did not. Lactate release into the fetal effluent was significantly reduced in both insulintreated GDM groups compared to the control group. In conclusion, placental glucose utilization is different between insulin-treated GDM placentae with and without fetal macrosomia. |
| doi_str_mv | 10.1515/JPM.2003.073 |
| format | Article |
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G. ; Osmond, D. T. D. ; Brennecke, S. P. ; Gude, N. M.</creator><creatorcontrib>King, R. G. ; Osmond, D. T. D. ; Brennecke, S. P. ; Gude, N. M.</creatorcontrib><description>The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies. Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, or 24 mM while the fetal D-glucose was maintained at 3mM. Hay WW: Regulation of placental metabolism by glucose supply. Reprod Fertil Dev 7 (1995) 365 C-D-glucose and Combs CA,E Gunderson, JL Kitzmiller, LA Gavin, EK Main: Relationship of fetal macrosomia to maternal postprandial glucose control during pregnancy. Diabetes Care 15 (1992) 1251 H-L-glucose were infused into the maternal circulation. Radioactivity, D-glucose and L-lactate levels were measured in the fetal and maternal effluent perfusates. Glucose uptake from the maternal perfusate, and transfer to the fetal effluent were not significantly different between groups. Insulin-treated GDM group without macrosomia had reduced glucose utilization compared to the control group while the insulin-treated GDM group with macrosomia did not. Lactate release into the fetal effluent was significantly reduced in both insulintreated GDM groups compared to the control group. In conclusion, placental glucose utilization is different between insulin-treated GDM placentae with and without fetal macrosomia.</description><identifier>ISSN: 0300-5577</identifier><identifier>EISSN: 1619-3997</identifier><identifier>DOI: 10.1515/JPM.2003.073</identifier><identifier>PMID: 14711103</identifier><identifier>CODEN: JPEMAO</identifier><language>eng</language><publisher>Berlin: Walter de Gruyter</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biological Transport ; Blood Glucose - analysis ; Delivery. Postpartum. Lactation ; Diabetes, Gestational - drug therapy ; Diabetes, Gestational - metabolism ; Diseases of mother, fetus and pregnancy ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Fetal Macrosomia - metabolism ; Gestational Age ; Glucose - metabolism ; Glycated Hemoglobin A - analysis ; Gynecology. Andrology. Obstetrics ; Humans ; Insulin - therapeutic use ; Intensive care medicine ; Maternal-Fetal Exchange ; Medical sciences ; Placenta - metabolism ; Pregnancy ; Pregnancy. Fetus. Placenta</subject><ispartof>Journal of perinatal medicine, 2003-01, Vol.31 (6), p.475-483</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-855e737d1f1e4bfe6e58cb1089e5a3c916d3e581094b599412427e1fd4bfce763</citedby><cites>FETCH-LOGICAL-c355t-855e737d1f1e4bfe6e58cb1089e5a3c916d3e581094b599412427e1fd4bfce763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15336167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14711103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, R. G.</creatorcontrib><creatorcontrib>Osmond, D. T. D.</creatorcontrib><creatorcontrib>Brennecke, S. P.</creatorcontrib><creatorcontrib>Gude, N. M.</creatorcontrib><title>Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes</title><title>Journal of perinatal medicine</title><addtitle>Journal of Perinatal Medicine</addtitle><description>The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies. Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, or 24 mM while the fetal D-glucose was maintained at 3mM. Hay WW: Regulation of placental metabolism by glucose supply. Reprod Fertil Dev 7 (1995) 365 C-D-glucose and Combs CA,E Gunderson, JL Kitzmiller, LA Gavin, EK Main: Relationship of fetal macrosomia to maternal postprandial glucose control during pregnancy. Diabetes Care 15 (1992) 1251 H-L-glucose were infused into the maternal circulation. Radioactivity, D-glucose and L-lactate levels were measured in the fetal and maternal effluent perfusates. Glucose uptake from the maternal perfusate, and transfer to the fetal effluent were not significantly different between groups. Insulin-treated GDM group without macrosomia had reduced glucose utilization compared to the control group while the insulin-treated GDM group with macrosomia did not. Lactate release into the fetal effluent was significantly reduced in both insulintreated GDM groups compared to the control group. In conclusion, placental glucose utilization is different between insulin-treated GDM placentae with and without fetal macrosomia.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Blood Glucose - analysis</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Diabetes, Gestational - drug therapy</subject><subject>Diabetes, Gestational - metabolism</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Fetal Macrosomia - metabolism</subject><subject>Gestational Age</subject><subject>Glucose - metabolism</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Insulin - therapeutic use</subject><subject>Intensive care medicine</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><issn>0300-5577</issn><issn>1619-3997</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhi1ERbeFG2fkC5zI1rPOxJsjrdqFqhUsKhculuOMiyEfi-0Iyq_HYVdUsjSS32de2Q9jL0EsAQHPrj_dLldCyKVQ8glbQAV1IetaPWULIYUoEJU6ZicxfhcCEHH1jB1DqQBAyAX7dekc2cRHxx0l0_He2DDGsfeGjwP_NvVm4LvOWBrm9L6b7BiJp2CGuBtD4mZo-ZR85_-Y5POGn0-cOj8UKZBJ1PJ7iulfmAtabxpKFJ-zI2e6SC8O85R9ubq8u3hf3HzcfLh4d1NYiZiKNSIpqVpwQGXjqCJc2wbEuiY00tZQtTJfgajLBuu6hFW5UgSuzbAlVclT9mbfuwvjzyk_RPc-Wuo6M9A4Ra0ABVaVyODbPTh_PwZyehd8b8KDBqFn0TqL1rNonUVn_NWhd2p6ah_hg9kMvD4AJlrTuSzM-vjIoZQVVCpzxZ7zMdHv_7kJP3ROFertXak3m89Xm_PtV72VfwFV25bz</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>King, R. G.</creator><creator>Osmond, D. T. D.</creator><creator>Brennecke, S. P.</creator><creator>Gude, N. M.</creator><general>Walter de Gruyter</general><general>De Gruyter</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes</title><author>King, R. G. ; Osmond, D. T. D. ; Brennecke, S. P. ; Gude, N. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-855e737d1f1e4bfe6e58cb1089e5a3c916d3e581094b599412427e1fd4bfce763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Blood Glucose - analysis</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Diabetes, Gestational - drug therapy</topic><topic>Diabetes, Gestational - metabolism</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Fetal Macrosomia - metabolism</topic><topic>Gestational Age</topic><topic>Glucose - metabolism</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Insulin - therapeutic use</topic><topic>Intensive care medicine</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, R. G.</creatorcontrib><creatorcontrib>Osmond, D. T. D.</creatorcontrib><creatorcontrib>Brennecke, S. P.</creatorcontrib><creatorcontrib>Gude, N. M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, R. G.</au><au>Osmond, D. T. D.</au><au>Brennecke, S. P.</au><au>Gude, N. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes</atitle><jtitle>Journal of perinatal medicine</jtitle><addtitle>Journal of Perinatal Medicine</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>31</volume><issue>6</issue><spage>475</spage><epage>483</epage><pages>475-483</pages><issn>0300-5577</issn><eissn>1619-3997</eissn><coden>JPEMAO</coden><abstract>The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies. Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, or 24 mM while the fetal D-glucose was maintained at 3mM. Hay WW: Regulation of placental metabolism by glucose supply. Reprod Fertil Dev 7 (1995) 365 C-D-glucose and Combs CA,E Gunderson, JL Kitzmiller, LA Gavin, EK Main: Relationship of fetal macrosomia to maternal postprandial glucose control during pregnancy. Diabetes Care 15 (1992) 1251 H-L-glucose were infused into the maternal circulation. Radioactivity, D-glucose and L-lactate levels were measured in the fetal and maternal effluent perfusates. Glucose uptake from the maternal perfusate, and transfer to the fetal effluent were not significantly different between groups. Insulin-treated GDM group without macrosomia had reduced glucose utilization compared to the control group while the insulin-treated GDM group with macrosomia did not. Lactate release into the fetal effluent was significantly reduced in both insulintreated GDM groups compared to the control group. In conclusion, placental glucose utilization is different between insulin-treated GDM placentae with and without fetal macrosomia.</abstract><cop>Berlin</cop><cop>New York, NY</cop><pub>Walter de Gruyter</pub><pmid>14711103</pmid><doi>10.1515/JPM.2003.073</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biological Transport Blood Glucose - analysis Delivery. Postpartum. Lactation Diabetes, Gestational - drug therapy Diabetes, Gestational - metabolism Diseases of mother, fetus and pregnancy Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Fetal Macrosomia - metabolism Gestational Age Glucose - metabolism Glycated Hemoglobin A - analysis Gynecology. Andrology. Obstetrics Humans Insulin - therapeutic use Intensive care medicine Maternal-Fetal Exchange Medical sciences Placenta - metabolism Pregnancy Pregnancy. Fetus. Placenta |
| title | Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes |
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