Targeting enzymes involved in spermidine metabolism of parasitic protozoa: a possible new strategy for anti-parasitic treatment

Sequencing data obtained from the Plasmodium, Anopheles gambiae and human genome projects provide a new basis for drug and vaccine development. One of the most characteristic features in the process of drug development against parasitic protozoa is target identification in a biological pathway. The...

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Veröffentlicht in:	Parasitology research (1987) 2003-12, Vol.91 (6), p.508-516
Hauptverfasser:	KAISER, A, GOTTWALD, A, MAIER, W, SEITZ, H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Agmatine Alkyl and Aryl Transferases - antagonists & inhibitors Alkyl and Aryl Transferases - chemistry Alkyl and Aryl Transferases - genetics Alkyl and Aryl Transferases - metabolism Amino Acid Sequence Amino acids Animal models Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiparasitic Agents - chemical synthesis Antiparasitic Agents - chemistry Binding Sites Biological and medical sciences Conserved Sequence Deoxyadenosines - chemical synthesis Deoxyadenosines - pharmacology DNA Primers Drug Design Drug development Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Enzymes Erythrocytes Eukaryota - metabolism Eukaryota - pathogenicity Genomes HSS gene Humans Initiation factor eIF-5A Malaria Medical sciences Metabolism Molecular Sequence Data NAD - metabolism Oxidoreductases Acting on CH-NH Group Donors - antagonists & inhibitors Oxidoreductases Acting on CH-NH Group Donors - chemistry Oxidoreductases Acting on CH-NH Group Donors - genetics Oxidoreductases Acting on CH-NH Group Donors - metabolism Parasites Pharmacology. Drug treatments Plasmodium - metabolism Plasmodium - pathogenicity Protozoa Sequence Alignment Sequence Homology, Amino Acid Spermidine Spermidine - biosynthesis Spermidine - metabolism Vaccine development
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