Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain

In humans, perinatal exposure to environmental tobacco smoke (ETS) is associated with neurobehavioral deficits. In the current study, we exposed Rhesus monkeys to ETS in late gestation and in the early neonatal period, and examined changes in neurotransmitter receptors in the brainstem and caudal po...

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Veröffentlicht in:	Brain research. Developmental brain research 2002-02, Vol.133 (2), p.175-179
Hauptverfasser:	Slotkin, T.A, Pinkerton, K.E, Auman, J.T, Qiao, D, Seidler, F.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - embryology Brain - growth & development Cell Membrane - drug effects Cell Membrane - metabolism Environmental Exposure Environmental tobacco smoke Female Macaca mulatta - embryology Macaca mulatta - growth & development Macaca mulatta - metabolism Muscarinic acetylcholine receptor Neurons - drug effects Neurons - metabolism Nicotine Nicotinic acetylcholine receptor Pregnancy Prenatal Exposure Delayed Effects Radioligand Assay Receptor, Muscarinic M2 Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Receptors, Muscarinic - drug effects Receptors, Muscarinic - metabolism Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Sudden Infant Death Syndrome Tobacco Smoke Pollution - adverse effects Up-Regulation - drug effects Up-Regulation - physiology β-Adrenergic receptor
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