SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model

The aim of the study was to investigate inhibitory effects of the receptor tyrosine kinase (RTK) inhibitor SU11248 against CSF-1R and osteoclast (OC) formation. We developed an in vivo model of breast cancer metastasis to evaluate efficacy of SU11248 against tumor growth and tumor-induced osteolysis...

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Veröffentlicht in:	Clinical & experimental metastasis 2003-01, Vol.20 (8), p.757-766
Hauptverfasser:	Murray, Lesley J, Abrams, Tinya J, Long, Kelly R, Ngai, Theresa J, Olson, Lisa M, Hong, Weiru, Keast, Paul K, Brassard, Jacqueline A, O'Farrell, Anne Marie, Cherrington, Julie M, Pryer, Nancy K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - pathology Bone Neoplasms - physiopathology Bone Neoplasms - secondary Breast Neoplasms - pathology Cell Adhesion Indoles - pharmacology Mice Mice, Nude Neoplasm Transplantation Osteoclasts Osteolysis Phosphorylation Pyrroles - pharmacology Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor, Macrophage Colony-Stimulating Factor - metabolism Tumor Cells, Cultured
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