Lamina Propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Proinflammatory Response Against an Intracellular Pathogen

Acute and lethal ileitis can be elicited in certain strains of inbred mice after oral infection with the intracellular protozoan parasite Toxoplasma gondii. The development of this inflammatory process is dependent upon the induction of a robust Th1 response, including overproduction of IFN-gamma, T...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-03, Vol.168 (6), p.2988-2996
Hauptverfasser:	Mennechet, Franck J. D, Kasper, Lloyd H, Rachinel, Nicolas, Li, Wen, Vandewalle, Alain, Buzoni-Gatel, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adjuvants, Immunologic - physiology Administration, Oral Animals CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - parasitology Cell Communication - immunology Cell Line, Transformed Cell Separation Chemokines - biosynthesis Chemokines - genetics Coculture Techniques Cytokines - physiology Female Ileitis - immunology Ileitis - parasitology Ileitis - prevention & control Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - parasitology Intestinal Mucosa - pathology Intracellular Fluid - immunology Intracellular Fluid - parasitology Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic RNA, Messenger - biosynthesis Toxoplasma - growth & development Toxoplasma - immunology Toxoplasmosis - immunology Toxoplasmosis - parasitology Toxoplasmosis - prevention & control Up-Regulation - immunology
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