Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis
Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epith...
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| Veröffentlicht in: | Journal of investigative dermatology 2002-03, Vol.118 (3), p.444-449 |
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| creator | Bäckman, Assar Ny, Annelii Edlund, Michael Ekholm, Elisabeth Ekstrand Hammarström, Barbro Törnell, Jan Wallbrandt, Pia Egelrud, Torbjörn Hansson, Lennart Wennbo, Håkan |
| description | Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epithelia. We have previously reported on increased expression of the stratum corneum chymotryptic enzyme in psoriasis. Here is reported an increased epidermal expression of stratum corneum chymotryptic enzyme also found in chronic lesions of atopic dermatitis. Transgenic mice expressing human stratum corneum chymotryptic enzyme in suprabasal epidermal keratinocytes were found to develop pathologic skin changes with increased epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus. The results suggest that stratum corneum chymotryptic enzyme may be involved in the pathogenesis of inflammatory skin diseases, and that stratum corneum chymotryptic enzyme and related enzymes should be evaluated as potential targets for new therapies. |
| doi_str_mv | 10.1046/j.0022-202x.2001.01684.x |
| format | Article |
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The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epithelia. We have previously reported on increased expression of the stratum corneum chymotryptic enzyme in psoriasis. Here is reported an increased epidermal expression of stratum corneum chymotryptic enzyme also found in chronic lesions of atopic dermatitis. Transgenic mice expressing human stratum corneum chymotryptic enzyme in suprabasal epidermal keratinocytes were found to develop pathologic skin changes with increased epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus. The results suggest that stratum corneum chymotryptic enzyme may be involved in the pathogenesis of inflammatory skin diseases, and that stratum corneum chymotryptic enzyme and related enzymes should be evaluated as potential targets for new therapies.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1046/j.0022-202x.2001.01684.x</identifier><identifier>PMID: 11874483</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Amino Acid Sequence - genetics ; Animals ; Biological and medical sciences ; Chronic Disease ; Dermatitis - etiology ; Dermatitis - pathology ; Dermatitis - physiopathology ; Dermatitis, Atopic - pathology ; Dermatology ; Disease Models, Animal ; Epidermis - enzymology ; Humans ; itch ; kallikrein ; Kallikreins ; Medical sciences ; Mice ; Mice, Transgenic - genetics ; Phenotype ; Pruritus ; Serine Endopeptidases - genetics ; Serine Endopeptidases - metabolism ; serine protease ; skin ; Skin - pathology ; Skin involvement in other diseases. 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General aspects ; transgenic mice</subject><ispartof>Journal of investigative dermatology, 2002-03, Vol.118 (3), p.444-449</ispartof><rights>2002 The Society for Investigative Dermatology, Inc</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-c27295d4bef360c564ff2b954ceaee1f90943b55b3205b2c2791ee16bd6976453</citedby><cites>FETCH-LOGICAL-c543t-c27295d4bef360c564ff2b954ceaee1f90943b55b3205b2c2791ee16bd6976453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13572670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11874483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bäckman, Assar</creatorcontrib><creatorcontrib>Ny, Annelii</creatorcontrib><creatorcontrib>Edlund, Michael</creatorcontrib><creatorcontrib>Ekholm, Elisabeth</creatorcontrib><creatorcontrib>Ekstrand Hammarström, Barbro</creatorcontrib><creatorcontrib>Törnell, Jan</creatorcontrib><creatorcontrib>Wallbrandt, Pia</creatorcontrib><creatorcontrib>Egelrud, Torbjörn</creatorcontrib><creatorcontrib>Hansson, Lennart</creatorcontrib><creatorcontrib>Wennbo, Håkan</creatorcontrib><title>Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epithelia. We have previously reported on increased expression of the stratum corneum chymotryptic enzyme in psoriasis. Here is reported an increased epidermal expression of stratum corneum chymotryptic enzyme also found in chronic lesions of atopic dermatitis. Transgenic mice expressing human stratum corneum chymotryptic enzyme in suprabasal epidermal keratinocytes were found to develop pathologic skin changes with increased epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus. The results suggest that stratum corneum chymotryptic enzyme may be involved in the pathogenesis of inflammatory skin diseases, and that stratum corneum chymotryptic enzyme and related enzymes should be evaluated as potential targets for new therapies.</description><subject>Amino Acid Sequence - genetics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Dermatitis - etiology</subject><subject>Dermatitis - pathology</subject><subject>Dermatitis - physiopathology</subject><subject>Dermatitis, Atopic - pathology</subject><subject>Dermatology</subject><subject>Disease Models, Animal</subject><subject>Epidermis - enzymology</subject><subject>Humans</subject><subject>itch</subject><subject>kallikrein</subject><subject>Kallikreins</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Transgenic - genetics</subject><subject>Phenotype</subject><subject>Pruritus</subject><subject>Serine Endopeptidases - genetics</subject><subject>Serine Endopeptidases - metabolism</subject><subject>serine protease</subject><subject>skin</subject><subject>Skin - pathology</subject><subject>Skin involvement in other diseases. 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The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epithelia. We have previously reported on increased expression of the stratum corneum chymotryptic enzyme in psoriasis. Here is reported an increased epidermal expression of stratum corneum chymotryptic enzyme also found in chronic lesions of atopic dermatitis. Transgenic mice expressing human stratum corneum chymotryptic enzyme in suprabasal epidermal keratinocytes were found to develop pathologic skin changes with increased epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus. The results suggest that stratum corneum chymotryptic enzyme may be involved in the pathogenesis of inflammatory skin diseases, and that stratum corneum chymotryptic enzyme and related enzymes should be evaluated as potential targets for new therapies.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>11874483</pmid><doi>10.1046/j.0022-202x.2001.01684.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence - genetics Animals Biological and medical sciences Chronic Disease Dermatitis - etiology Dermatitis - pathology Dermatitis - physiopathology Dermatitis, Atopic - pathology Dermatology Disease Models, Animal Epidermis - enzymology Humans itch kallikrein Kallikreins Medical sciences Mice Mice, Transgenic - genetics Phenotype Pruritus Serine Endopeptidases - genetics Serine Endopeptidases - metabolism serine protease skin Skin - pathology Skin involvement in other diseases. Miscellaneous. General aspects transgenic mice |
| title | Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis |
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