Lung tumors evaluated with FDG-PET and dynamic CT: The relationship between vascular density and glucose metabolism
The aim of the current study was to evaluate the relationship between FDG-PET and dynamic CT in lung tumors. Forty consecutive patients with pulmonary tumors underwent whole-body FDG-PET and contrast-enhanced dynamic CT. The size of tumors was 2.6 +/- 0.2 cm (mean +/- SD) at the largest diameter. Th...
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| Veröffentlicht in: | Journal of computer assisted tomography 2002-03, Vol.26 (2), p.185-190 |
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| container_title | Journal of computer assisted tomography |
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| creator | TATEISHI, Ukihide NISHIHARA, Hiroshi TSUKAMOTO, Eriko MORIKAWA, Toshiaki TAMAKI, Nagara MIYASAKA, Kazuo |
| description | The aim of the current study was to evaluate the relationship between FDG-PET and dynamic CT in lung tumors.
Forty consecutive patients with pulmonary tumors underwent whole-body FDG-PET and contrast-enhanced dynamic CT. The size of tumors was 2.6 +/- 0.2 cm (mean +/- SD) at the largest diameter. The standardized uptake value (SUV) of FDG-PET, peak attenuation (APA), and relative flow (RF) of dynamic CT were evaluated. All patients underwent surgery, and tissue samples were available to be studied. The intratumoral microvessel densities (MVDs) were counted and compared with the radiologic parameters. The duration between radiologic examinations and surgery was within 2 weeks in all patients.
The mean SUV, APA, and RF of lung cancers were significantly higher than those of benign lesions (p < 0.05). The mean APA and RF of lung cancers correlated with mean SUV (APA : r = 0.665, p < 0.0001; RF: r = 0.848, p < 0.05) and mean MVD (APA: r = 0.801, p < 0.0001; RF: r = 0.723, p < 0.05). The mean SUV of lung cancers correlated with the mean MVD (r = 0.612, p < 0.001). No correlation was found between the mean APA, RF, SUV, and MVD in benign tumors.
The APA and RF of dynamic CT correlated with the SUV of FDG-PET imaging in lung cancer. The APA and RF of dynamic CT as an index of blood pooling may be related to increased glucose metabolism in lung cancer. |
| doi_str_mv | 10.1097/00004728-200203000-00004 |
| format | Article |
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Forty consecutive patients with pulmonary tumors underwent whole-body FDG-PET and contrast-enhanced dynamic CT. The size of tumors was 2.6 +/- 0.2 cm (mean +/- SD) at the largest diameter. The standardized uptake value (SUV) of FDG-PET, peak attenuation (APA), and relative flow (RF) of dynamic CT were evaluated. All patients underwent surgery, and tissue samples were available to be studied. The intratumoral microvessel densities (MVDs) were counted and compared with the radiologic parameters. The duration between radiologic examinations and surgery was within 2 weeks in all patients.
The mean SUV, APA, and RF of lung cancers were significantly higher than those of benign lesions (p < 0.05). The mean APA and RF of lung cancers correlated with mean SUV (APA : r = 0.665, p < 0.0001; RF: r = 0.848, p < 0.05) and mean MVD (APA: r = 0.801, p < 0.0001; RF: r = 0.723, p < 0.05). The mean SUV of lung cancers correlated with the mean MVD (r = 0.612, p < 0.001). No correlation was found between the mean APA, RF, SUV, and MVD in benign tumors.
The APA and RF of dynamic CT correlated with the SUV of FDG-PET imaging in lung cancer. The APA and RF of dynamic CT as an index of blood pooling may be related to increased glucose metabolism in lung cancer.]]></description><identifier>ISSN: 0363-8715</identifier><identifier>EISSN: 1532-3145</identifier><identifier>DOI: 10.1097/00004728-200203000-00004</identifier><identifier>PMID: 11884771</identifier><identifier>CODEN: JCATD5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - blood supply ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - physiopathology ; Female ; Fluorodeoxyglucose F18 ; Glucose - metabolism ; Humans ; Lung Neoplasms - blood supply ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - physiopathology ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Radiopharmaceuticals ; Tomography, Emission-Computed ; Tomography, X-Ray Computed - methods ; Tumors of the respiratory system and mediastinum</subject><ispartof>Journal of computer assisted tomography, 2002-03, Vol.26 (2), p.185-190</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-12430a884da45784526a12a6fe1e48ae94ed6d0310bcd8714d875a226c02af483</citedby><cites>FETCH-LOGICAL-c372t-12430a884da45784526a12a6fe1e48ae94ed6d0310bcd8714d875a226c02af483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13567104$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11884771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TATEISHI, Ukihide</creatorcontrib><creatorcontrib>NISHIHARA, Hiroshi</creatorcontrib><creatorcontrib>TSUKAMOTO, Eriko</creatorcontrib><creatorcontrib>MORIKAWA, Toshiaki</creatorcontrib><creatorcontrib>TAMAKI, Nagara</creatorcontrib><creatorcontrib>MIYASAKA, Kazuo</creatorcontrib><title>Lung tumors evaluated with FDG-PET and dynamic CT: The relationship between vascular density and glucose metabolism</title><title>Journal of computer assisted tomography</title><addtitle>J Comput Assist Tomogr</addtitle><description><![CDATA[The aim of the current study was to evaluate the relationship between FDG-PET and dynamic CT in lung tumors.
Forty consecutive patients with pulmonary tumors underwent whole-body FDG-PET and contrast-enhanced dynamic CT. The size of tumors was 2.6 +/- 0.2 cm (mean +/- SD) at the largest diameter. The standardized uptake value (SUV) of FDG-PET, peak attenuation (APA), and relative flow (RF) of dynamic CT were evaluated. All patients underwent surgery, and tissue samples were available to be studied. The intratumoral microvessel densities (MVDs) were counted and compared with the radiologic parameters. The duration between radiologic examinations and surgery was within 2 weeks in all patients.
The mean SUV, APA, and RF of lung cancers were significantly higher than those of benign lesions (p < 0.05). The mean APA and RF of lung cancers correlated with mean SUV (APA : r = 0.665, p < 0.0001; RF: r = 0.848, p < 0.05) and mean MVD (APA: r = 0.801, p < 0.0001; RF: r = 0.723, p < 0.05). The mean SUV of lung cancers correlated with the mean MVD (r = 0.612, p < 0.001). No correlation was found between the mean APA, RF, SUV, and MVD in benign tumors.
The APA and RF of dynamic CT correlated with the SUV of FDG-PET imaging in lung cancer. The APA and RF of dynamic CT as an index of blood pooling may be related to increased glucose metabolism in lung cancer.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - blood supply</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - physiopathology</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Lung Neoplasms - blood supply</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Radiopharmaceuticals</subject><subject>Tomography, Emission-Computed</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0363-8715</issn><issn>1532-3145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvGyEUhVHUKHHT_oWKTbqbltcMOLvIebSSpXThrkfXcCemYmZcYGL534fEbrIsCxBX37kc7iGEcvaNs7n-zspSWphKMCaYLLfqtXRCZryWopJc1R_IjMlGVkbz-px8TOkPY1xLqc7IOefGKK35jKTlNDzSPPVjTBSfIEyQ0dGdzxt6d3Nf_bpdURgcdfsBem_pYnVFVxukEQNkPw5p47d0jXmHONAnSHYKEKnDIfm8f1U-hsmOCWmPGdZj8Kn_RE47CAk_H88L8vvudrX4US0f7n8urpeVlVrkigslGRSjDlStjapFA1xA0yFHZQDnCl3jmORsbV35pSpbDUI0lgnolJEX5Ouh7zaOfydMue19shgCDDhOqS2DYVJz9l9QsNoUA_MCmgNo45hSxK7dRt9D3LectS_JtP-Sad-SOZSK9MvxjWndo3sXHqMowOURKFOE0EUYrE_vnKyb4lXJZ4QLlYE</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>TATEISHI, Ukihide</creator><creator>NISHIHARA, Hiroshi</creator><creator>TSUKAMOTO, Eriko</creator><creator>MORIKAWA, Toshiaki</creator><creator>TAMAKI, Nagara</creator><creator>MIYASAKA, Kazuo</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Lung tumors evaluated with FDG-PET and dynamic CT: The relationship between vascular density and glucose metabolism</title><author>TATEISHI, Ukihide ; NISHIHARA, Hiroshi ; TSUKAMOTO, Eriko ; MORIKAWA, Toshiaki ; TAMAKI, Nagara ; MIYASAKA, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-12430a884da45784526a12a6fe1e48ae94ed6d0310bcd8714d875a226c02af483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - blood supply</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - physiopathology</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Lung Neoplasms - blood supply</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Radiopharmaceuticals</topic><topic>Tomography, Emission-Computed</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TATEISHI, Ukihide</creatorcontrib><creatorcontrib>NISHIHARA, Hiroshi</creatorcontrib><creatorcontrib>TSUKAMOTO, Eriko</creatorcontrib><creatorcontrib>MORIKAWA, Toshiaki</creatorcontrib><creatorcontrib>TAMAKI, Nagara</creatorcontrib><creatorcontrib>MIYASAKA, Kazuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of computer assisted tomography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TATEISHI, Ukihide</au><au>NISHIHARA, Hiroshi</au><au>TSUKAMOTO, Eriko</au><au>MORIKAWA, Toshiaki</au><au>TAMAKI, Nagara</au><au>MIYASAKA, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung tumors evaluated with FDG-PET and dynamic CT: The relationship between vascular density and glucose metabolism</atitle><jtitle>Journal of computer assisted tomography</jtitle><addtitle>J Comput Assist Tomogr</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>26</volume><issue>2</issue><spage>185</spage><epage>190</epage><pages>185-190</pages><issn>0363-8715</issn><eissn>1532-3145</eissn><coden>JCATD5</coden><abstract><![CDATA[The aim of the current study was to evaluate the relationship between FDG-PET and dynamic CT in lung tumors.
Forty consecutive patients with pulmonary tumors underwent whole-body FDG-PET and contrast-enhanced dynamic CT. The size of tumors was 2.6 +/- 0.2 cm (mean +/- SD) at the largest diameter. The standardized uptake value (SUV) of FDG-PET, peak attenuation (APA), and relative flow (RF) of dynamic CT were evaluated. All patients underwent surgery, and tissue samples were available to be studied. The intratumoral microvessel densities (MVDs) were counted and compared with the radiologic parameters. The duration between radiologic examinations and surgery was within 2 weeks in all patients.
The mean SUV, APA, and RF of lung cancers were significantly higher than those of benign lesions (p < 0.05). The mean APA and RF of lung cancers correlated with mean SUV (APA : r = 0.665, p < 0.0001; RF: r = 0.848, p < 0.05) and mean MVD (APA: r = 0.801, p < 0.0001; RF: r = 0.723, p < 0.05). The mean SUV of lung cancers correlated with the mean MVD (r = 0.612, p < 0.001). No correlation was found between the mean APA, RF, SUV, and MVD in benign tumors.
The APA and RF of dynamic CT correlated with the SUV of FDG-PET imaging in lung cancer. The APA and RF of dynamic CT as an index of blood pooling may be related to increased glucose metabolism in lung cancer.]]></abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>11884771</pmid><doi>10.1097/00004728-200203000-00004</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Non-Small-Cell Lung - blood supply Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - physiopathology Female Fluorodeoxyglucose F18 Glucose - metabolism Humans Lung Neoplasms - blood supply Lung Neoplasms - diagnostic imaging Lung Neoplasms - physiopathology Male Medical sciences Middle Aged Pneumology Radiopharmaceuticals Tomography, Emission-Computed Tomography, X-Ray Computed - methods Tumors of the respiratory system and mediastinum |
| title | Lung tumors evaluated with FDG-PET and dynamic CT: The relationship between vascular density and glucose metabolism |
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