Maturation alters the contribution of potassium channels to resting and 5HT-induced tone in small cerebral arteries of the sheep

To address the hypothesis that maturation alters the contribution of K-channels to resting and agonist-induced tone in small cerebral arteries, second branch middle cerebral arteries (∼200 μm) were taken from term fetal (139–141 days gestation) and adult sheep, denuded of endothelium, and mounted in...

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Veröffentlicht in:	Brain research. Developmental brain research 2002-02, Vol.133 (2), p.81-91
Hauptverfasser:	Teng, Guo Qi, Nauli, Surya M, Brayden, Joseph E, Pearce, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT Aging - metabolism Animals Brain - blood supply Brain - growth & development Brain - metabolism Cerebral arteries Cerebral Arteries - drug effects Cerebral Arteries - growth & development Cerebral Arteries - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Fetus Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Tonus - drug effects Muscle Tonus - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - growth & development Muscle, Smooth, Vascular - metabolism Myogenic tone Potassium - pharmacology Potassium Channel Blockers - pharmacology Potassium channels Potassium Channels - drug effects Potassium Channels - metabolism Pregnancy Serotonin - metabolism Serotonin - pharmacology Sheep Vasoconstriction - drug effects Vasoconstriction - physiology
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