Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia

This report describes four patients with pneumococcal pneumonia in whom empirical treatment with levofloxacin failed. In these patients, the isolates of Streptococcus pneumoniae were resistant to levofloxacin, and in two of them the resistance appeared to have been acquired during the current course...

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Veröffentlicht in:	The New England journal of medicine 2002-03, Vol.346 (10), p.747-750
Hauptverfasser:	Davidson, Ross, Cavalcanti, Rodrigo, Brunton, James L, Bast, Darrin J, de Azavedo, Joyce C.S, Kibsey, Pamela, Fleming, Christine, Low, Donald E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria Biological and medical sciences Case studies Drug resistance Drug Resistance, Bacterial Fatal Outcome Female gatifloxacin Humans Levofloxacin Male Medical sciences Microbial Sensitivity Tests Middle Aged moxifloxacin Ofloxacin - pharmacology Ofloxacin - therapeutic use Pharmacology. Drug treatments Pneumonia Pneumonia, Pneumococcal - drug therapy Pneumonia, Pneumococcal - microbiology Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - isolation & purification Treatment Failure
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