Surfactant-free, biodegradable nanoparticles for aerosol therapy based on the branched polyesters, DEAPA-PVAL-g-PLGA

This study describes the development of surfactant-free, biodegradable nanoparticle systems with varying physicochemical properties and their suitability for pulmonary application via nebulization. Nanoparticle suspensions were formulated from the branched polyester, diethylaminopropyl amine-poly(vi...

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Veröffentlicht in:	Pharmaceutical research 2003-12, Vol.20 (12), p.2011-2020
Hauptverfasser:	DAILEY, L. A, KLEEMANN, E, WITTMAR, M, GESSLER, T, SCHMEHL, T, ROBERTS, C, SEEGER, W, KISSEL, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Alcohol Biodegradation Biological and medical sciences Biotransformation Carboxymethylcellulose Sodium Cellulose Chemistry, Pharmaceutical Drug Delivery Systems Drug Stability General pharmacology Lactic Acid - chemistry Medical sciences Microscopy Microscopy, Atomic Force Microscopy, Confocal Microspheres Nanoparticles Nephelometry and Turbidimetry Particle Size Pharmaceutic Aids Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters - chemistry Polyglactin 910 - analogs & derivatives Polyglactin 910 - chemistry Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polymers - chemistry Polyvinyl Alcohol - chemistry Scientific imaging Spectrometry, Fluorescence Surfactants Suspensions Toxicity
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