Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

Prostaglandins (PGs), bioactive lipid molecules produced by cyclooxygenase enzymes (COX-1 and COX-2), have diverse biological activities, including growth-promoting actions on gastrointestinal mucosa 1 , 2 , 3 , 4 , 5 . They are also implicated in the growth of colonic polyps and cancers 6 . However...

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Veröffentlicht in:	Nature medicine 2002-03, Vol.8 (3), p.289-293
Hauptverfasser:	Pai, Rama, Soreghan, Brian, Szabo, Imre L., Pavelka, Meredith, Baatar, Dolgor, Tarnawski, Andrzej S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biomedical and Life Sciences Biomedicine Cancer Research Cell growth Cell Line Colonic Neoplasms - metabolism Colorectal cancer Dinoprostone - metabolism Dinoprostone - pharmacology Enzyme Inhibitors - pharmacology Epidermal growth factor Gastric Mucosa - cytology Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Genes, src - physiology Humans Hypertrophy - pathology Inactivation Infectious Diseases Kinases Ligands MAP Kinase Signaling System - physiology Matrix Metalloproteinases - metabolism Metabolic Diseases Mitogen-Activated Protein Kinase 1 - metabolism Molecular Medicine Neurosciences Phosphorylation Proteins Quinazolines - pharmacology Rats Rats, Sprague-Dawley Receptor, Epidermal Growth Factor - metabolism Transcriptional Activation - physiology Tyrphostins - pharmacology
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